Outputs (4)

A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease (2016)
Journal Article
Barron, M., Gartlon, J., Dawson, L. A., Atkinson, P. J., & Pardon, M. (2017). A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease. Experimental Gerontology, 94, 103-107. https://doi.org/10.1016/j.exger.2016.12.006

Alzheimer's disease (AD), the predominant form of dementia, is highly correlated with the abnormal hyperphosphorylation and aggregation of tau. Immune responses are key drivers of AD and how they contribute to tau pathology in human disease remains l... Read More about A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease.

A novel role for the immunophilin FKBP52 in motor coordination (2016)
Journal Article
Young, M. J., Geiszler, P. C., & Pardon, M. (in press). A novel role for the immunophilin FKBP52 in motor coordination. Behavioural Brain Research, 313, https://doi.org/10.1016/j.bbr.2016.07.015

FKBP52 is a ubiquitously distributed immunophilin that has been associated with wideranging functions in cell signalling as well as hormonal and stress responses. Amongst other pathways, it acts via complex-formation with corticosteroid receptors and... Read More about A novel role for the immunophilin FKBP52 in motor coordination.

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice (2016)
Journal Article
Ebada, M. E. E., Kendall, D. A., & Pardon, M. (2016). Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice. Behavioural Brain Research, 311, https://doi.org/10.1016/j.bbr.2016.05.051

Physical exercise can improve cognition but whether this is related to motivation levels is unknown. Voluntary wheel running is a rewarding activity proposed as a model of motivation to exercise. To question the potential effects of exercise motivati... Read More about Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice.

Impaired burrowing is the most prominent behavioral deficit of aging htau mice (2016)
Journal Article
Geiszler, P. C., Barron, M., & Pardon, M. (in press). Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience, https://doi.org/10.1016/j.neuroscience.2016.05.004

htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer's disease. Whilst histopathological changes in htau mice have been researched in t... Read More about Impaired burrowing is the most prominent behavioral deficit of aging htau mice.