Outputs (72)

B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins (2014)
Journal Article
Ng, P. P., BALL, J., Kuo, C., Wang, S., Einav, S., Arcaini, L., …Levy, S. (2014). B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins. Blood, 123(10), 1512–1515. https://doi.org/10.1182/blood-2013-10-532895

Chronic hepatitis C virus (HCV) infection has been implicated in the induction and maintenance of B-cell lymphomas. The strongest evidence for this derives from clinical observations of tumor regressions upon antiviral treatments. Here we used multip... Read More about B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins.

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission (2013)
Journal Article
Tarr, A. W., Lafaye, P., Meredith, L., Damier-Piolle, L., Urbanowicz, R. A., Meola, A., …Krey, T. (2013). An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission. Hepatology, 58(3), 932-939. https://doi.org/10.1002/hep.26430

Severe liver disease caused by chronic hepatitis C virus is the major indication for liver transplantation. Despite recent advances in antiviral therapy, drug toxicity and unwanted side effects render effective treatment in liver-transplanted patient... Read More about An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.

Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host (2012)
Journal Article
Brown, R. J., Hudson, N., Wilson, G., Rehman, S. U., Jabbari, S., Hu, K., …Ball, J. K. (2012). Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host. Journal of Virology, 86(22), https://doi.org/10.1128/JVI.01079-12

Genetic variability is a hallmark of RNA virus populations. However, transmission to a new host often results in a marked decrease in population diversity. This genetic bottlenecking is observed during hepatitis C virus (HCV) transmission and can ari... Read More about Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.

The Role of Humoral Innate Immunity in Hepatitis C Virus Infection (2012)
Journal Article
Tarr, A. W., Urbanowicz, R. A., & Ball, J. K. (2012). The Role of Humoral Innate Immunity in Hepatitis C Virus Infection. Viruses, 4(1), 1-27. https://doi.org/10.3390/v4010001

Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed. Spontaneous resoluti... Read More about The Role of Humoral Innate Immunity in Hepatitis C Virus Infection.

The role of neutralizing antibodies in hepatitis C virus infection (2012)
Journal Article
Edwards, V. C., Tarr, A. W., Urbanowicz, R. A., & Ball, J. K. (2012). The role of neutralizing antibodies in hepatitis C virus infection. Journal of General Virology, 93(1), 1-19. https://doi.org/10.1099/vir.0.035956-0

Hepatitis C virus (HCV) is a blood-borne virus estimated to infect around 170 million people worldwide and is, therefore, a major disease burden. In some individuals the virus is spontaneously cleared during the acute phase of infection, whilst in ot... Read More about The role of neutralizing antibodies in hepatitis C virus infection.

Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype (2011)
Journal Article
Tarr, A. W., Urbanowicz, R. A., Hamed, M. R., Albecka, A., McClure, C. P., Brown, R. J., …Ball, J. K. (2011). Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype. Journal of Virology, 85(9), 4246-4257. https://doi.org/10.1128/JVI.01332-10

Neutralizing antibodies have a role in controlling hepatitis C virus (HCV) infection. A successful vaccine will need to elicit potently neutralizing antibodies that are capable of preventing the infection of genetically diverse viral isolates. Howeve... Read More about Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype.

Identification of new functional regions in hepatitis C virus envelope glycoprotein E2 (2011)
Journal Article
Albecka, A., Montserret, R., Krey, T., Tarr, A. W., Diesis, E., Ball, J. K., …Dubuisson, J. (2011). Identification of new functional regions in hepatitis C virus envelope glycoprotein E2. Journal of Virology, 85(4), 1777-1792. https://doi.org/10.1128/JVI.02170-10

Little is known about the structure of the envelope glycoproteins of hepatitis C virus (HCV). To identify new regions essential for the function of these glycoproteins, we generated HCV pseudoparticles (HCVpp) containing HCV envelope glycoproteins, E... Read More about Identification of new functional regions in hepatitis C virus envelope glycoprotein E2.

Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry (2010)
Journal Article
Brown, K. S., Keogh, M. J., Owsianka, A. M., Adair, R., Patel, A. H., Arnold, J. N., …Hickling, T. P. (2010). Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry. Protein and Cell, 1(7), 664-674. https://doi.org/10.1007/s13238-010-0088-9

Mannan-binding lectin (MBL) is a soluble innate immune protein that binds to glycosylated targets. MBL acts as an opsonin and activates complement, contributing to the destruction and clearance of infecting microorganisms. Hepatitis C virus (HCV) enc... Read More about Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein (2008)
Journal Article
Owsianka, A. M., Tarr, A. W., Keck, Z. Y., Li, T. K., Witteveldt, J., Adair, R., …Patel, A. H. (2008). Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein. Journal of General Virology, 89(3), 653-659. https://doi.org/10.1099/vir.0.83386-0

The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection b... Read More about Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein.

Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease (2008)
Journal Article
Hamed, M. R., Tarr, A. W., McClure, C. P., Ball, J. K., Hickling, T. P., & Irving, W. L. (2008). Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease. Journal of Viral Hepatitis, 15(5), 339-345. https://doi.org/10.1111/j.1365-2893.2007.00947.x

Hepatitis C virus (HCV) causes acute and chronic liver diseases in humans. Its two envelope glycoproteins, E1 and E2, provide a target for host immune recognition. HCV genotypes are classified into six genetic groups. To study the role of anti-HCV E1... Read More about Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease.