Outputs (4)

Effect of 3-mercaptopyruvate sulfurtransferase (3-MST) inhibitors on contractile responses in porcine coronary artery (2025)
Journal Article
Almaheize, M., Alharthi, S., Hemp, P., Mattos, J., Van Leer, M., Garle, M., Alexander, S., & Roberts, R. (2025). Effect of 3-mercaptopyruvate sulfurtransferase (3-MST) inhibitors on contractile responses in porcine coronary artery. British Journal of Pharmacology, https://doi.org/10.1111/bph.70141

Background and Purpose
Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). Although exogenous H2S is known to produce vasodilatatio... Read More about Effect of 3-mercaptopyruvate sulfurtransferase (3-MST) inhibitors on contractile responses in porcine coronary artery.

GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid (2023)
Journal Article
Harper, A., Chapel, M., Hodgson, G., Malinowski, K., Yates, I., Garle, M., & Ralevic, V. (2023). GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid. Vascular Pharmacology, 152, Article 107199. https://doi.org/10.1016/j.vph.2023.107199

Background and aims:
Myeloperoxidase (MPO) and its principal reaction product hypochlorous acid (HOCl) are part of the innate immune response but are also associated with endothelial dysfunction, thought to involve a reduction in nitric oxide (NO)... Read More about GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid.

Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase (2018)
Journal Article
Donovan, J., Wong, P., Garle, M., Alexander, S. P., Dunn, W. R., & Ralevic, V. (in press). Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase. Acta Physiologica, Article e13126. https://doi.org/10.1111/apha.13126

Aim: Hypoxia causes vasodilatation of coronary arteries which protects the heart from ischaemic damage through mechanisms including the generation of hydrogen sulfide (H2S), but the influence of the perivascular adipose tissue (PVAT) and myocardium i... Read More about Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, https://doi.org/10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.