Outputs (2)

Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice (2025)
Journal Article
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J., O’Neil, D., Aagaard, K. M., Gibson, C. L., Heery, D. M., & Moran, P. M. (2025). Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice. Scientific Reports, 15(1), Article 8347. https://doi.org/10.1038/s41598-025-92938-1

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigate... Read More about Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice (2017)
Journal Article
Oyegbami, O., Collins, H. M., Pardon, M.-C., Ebling, F. J., Heery, D. M., & Moran, P. M. (2017). Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice. Current Alzheimer Research, 14(8), 850-860. https://doi.org/10.2174/1567205014666170317113159

In addition to cognitive decline, Alzheimer’s disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as ‘sundowning’. These symptoms a... Read More about Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice.