Outputs (7)

Membrane-Inserting α-Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity (2025)
Journal Article
Schiazza, L., Yilmaz, G., Gershkovich, P., Yeh, V., Bonev, B., Laughton, C., Stolnik, S., & Mantovani, G. (2025). Membrane-Inserting α-Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity. Chemistry of Materials, https://doi.org/10.1021/acs.chemmater.5c00658

Membrane-inserting materials bearing a lipid residue at one end of their macromolecular chain, α-lipid polymers, are increasingly utilized in biological and pharmaceutical fields. Insertion of these materials into lipid membranes underlines several c... Read More about Membrane-Inserting α-Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity.

Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo (2022)
Journal Article
Mastrotto, F., Pirazzini, M., Negro, S., Salama, A., Martinez-Pomares, L., & Mantovani, G. (2022). Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo. Journal of the American Chemical Society, 144(50), 23134-23147. https://doi.org/10.1021/jacs.2c10757

The mannose receptor (CD206) is an endocytic receptor expressed by selected innate immune cells and nonvascular endothelium, which plays a critical role in both homeostasis and pathogen recognition. Although its involvement in the development of seve... Read More about Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo.

Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo (2022)
Journal Article
Mastrotto, F., Pirazzini, M., Negro, S., Salama, A., Martinez-Pomares, L., & Mantovani, G. (2022). Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo. Journal of the American Chemical Society, 144(50), 23134–23147. https://doi.org/10.1021/jacs.2c10757

The mannose receptor (CD206) is an endocytic receptor expressed by selected innate immune cells and nonvascular endothelium, which plays a critical role in both homeostasis and pathogen recognition. Although its involvement in the development of seve... Read More about Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo.

A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus (2022)
Journal Article
Catania, R., Onion, D., Russo, E., Zelzer, M., Mantovani, G., Huett, A., & Stolnik, S. (2022). A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus. RSC Advances, 12(26), 16561-16569. https://doi.org/10.1039/d2ra02307e

Control over intracellular release of therapeutic compounds incorporated into nano-carriers will open new possibilities for targeted treatments of various diseases including cancer, and viral and bacterial infections. Here we report our study on mech... Read More about A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus.

Study on Significance of Receptor Targeting in Killing of Intracellular Bacteria with Membrane-Impermeable Antibiotics (2021)
Journal Article
Catania, R., Mastrotto, F., Moore, C. J., Bosquillon, C., Falcone, F. H., Huett, A., Mantovani, G., & Stolnik, S. (2021). Study on Significance of Receptor Targeting in Killing of Intracellular Bacteria with Membrane-Impermeable Antibiotics. Advanced Therapeutics, 4(12), Article 2100168. https://doi.org/10.1002/adtp.202100168

Water-soluble antibiotics are largely excluded from therapy of intracellular infections, such as Shigella spp., Listeria spp., or Salmonella spp., due to their inability to permeate mammalian cell membrane. Here, the authors study if targeting offers... Read More about Study on Significance of Receptor Targeting in Killing of Intracellular Bacteria with Membrane-Impermeable Antibiotics.

Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations (2021)
Journal Article
Petch, J. E., Gurnani, P., Yilmaz, G., Mastrotto, F., Alexander, C., Heeb, S., Cámara, M., & Mantovani, G. (2021). Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations. ACS Applied Materials and Interfaces, 13(16), 19230-19243. https://doi.org/10.1021/acsami.1c00907

The selective isolation of bacteria from mixed populations has been investigated in varied applications ranging from differential pathogen identification in medical diagnostics and food safety to the monitoring of microbial stress dynamics in industr... Read More about Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations.

Polymers for binding of the gram-positive oral pathogen Streptococcus mutans (2017)
Journal Article
Magennis, E. P., Francini, N., Mastrotto, F., Catania, R., Redhead, M., Fernandez-Trillo, F., Bradshaw, D., Churchley, D., Winzer, K., Alexander, C., & Mantovani, G. (2017). Polymers for binding of the gram-positive oral pathogen Streptococcus mutans. PLoS ONE, 12(7), Article e018008. https://doi.org/10.1371/journal.pone.0180087

Streptococcus mutans is the most significant pathogenic bacterium implicated in the formation of dental caries and, both directly and indirectly, has been associated with severe conditions such as multiple sclerosis, cerebrovascular and peripheral ar... Read More about Polymers for binding of the gram-positive oral pathogen Streptococcus mutans.