Outputs (23)

Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme (2023)
Journal Article
Jandu, A. K., Nitayamekin, A., Stevenson, J., Beed, M., Vohra, R. S., Wilson, V. G., & Lobo, D. N. (2023). Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme. World Journal of Surgery, 47(11), 2724-2732. https://doi.org/10.1007/s00268-023-07170-7

Background: Evidence suggests that physical fitness interventions, mental health support and nutritional advice before surgery (prehabilitation) could reduce hospital stay and improve quality of life of patients with cancer. In this study we captured... Read More about Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme.

Prehabilitation: high-quality evidence is still required (2022)
Journal Article
Lobo, D. N., Skořepa, P., Gomez, D., & Greenhaff, P. L. (2022). Prehabilitation: high-quality evidence is still required. British Journal of Anaesthesia, https://doi.org/10.1016/j.bja.2022.09.016

Prehabilitation comprises multidisciplinary healthcare interventions, including exercise, nutritional optimisation, and psychological preparation, which aim to dampen the metabolic response to surgery, shorten the period of recovery, reduce complicat... Read More about Prehabilitation: high-quality evidence is still required.

M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β (2022)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2022). M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β. Scientific Reports, 12(1), Article 16842. https://doi.org/10.1038/s41598-022-20811-6

High expression of polymeric immunoglobulin receptor (PIGR) in breast cancer is associated with increased 5-year survival rate. However, the factors influencing PIGR expression in breast cancer have not been elucidated. The aim of this study was to d... Read More about M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Lobo, D. N., Szewczyk, N., Narici, M., Prats, C., Macdonald, I. A., & Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism (2022)
Journal Article
Jaconelli, M., Greenhaff, P. L., Atherton, P. J., Lobo, D. N., & Brook, M. S. (2022). The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism. Clinical Nutrition, 41(3), 709-722. https://doi.org/10.1016/j.clnu.2022.01.023

Background & aims

Elective surgery induces skeletal muscle wasting driven by an imbalance between muscle protein synthesis and breakdown. From examination of diverse stable isotope tracer techniques, the dynamic processes driving this imbalance ar... Read More about The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article
Seehra, J. K., Lewis-Lloyd, C., Koh, A., Theophilidou, E., Daliya, P., Adiamah, A., & Lobo, D. N. (2021). Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020. World Journal of Surgery, 45(11), 3266-3277. https://doi.org/10.1007/s00268-021-06268-0

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function (2020)
Journal Article
Atkins, R., Constantin-Teodosiu, D., Varadhan, K. K., Constantin, D., Lobo, D. N., & Greenhaff, P. L. (2021). Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function. Clinical Nutrition, 40(3), 1046-1051. https://doi.org/10.1016/j.clnu.2020.07.006

© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rates... Read More about Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function.

Perioperative nutrition: Recommendations from the ESPEN expert group (2020)
Journal Article
Lobo, D. N., Gianotti, L., Adiamah, A., Barazzoni, R., Deutz, N., Dhatariya, K., Greenhaff, P. L., Hiesmayr, M., Jakobsen, D., Klek, S., Krznaric, Z., Ljungqvist, O., McMillan, D., Rollins, K., Sekeljic, M., Skipworth, R., Stanga, Z., Stockley, A., Stockley, R., & Weimann, A. (2020). Perioperative nutrition: Recommendations from the ESPEN expert group. Clinical Nutrition, 39(11), 3211-3227. https://doi.org/10.1016/j.clnu.2020.03.038

© 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in N... Read More about Perioperative nutrition: Recommendations from the ESPEN expert group.

The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials (2020)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., Scott, M. J., & Lobo, D. N. (2020). The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials. European Journal of Anaesthesiology, 37(8), 659-670. https://doi.org/10.1097/eja.0000000000001165

BACKGROUND
There has recently been increasing interest in the use of peri-operative intravenous lidocaine (IVL) due to its analgesic, anti-inflammatory and opioid-sparing effects. However, these potential benefits are not well established in electi... Read More about The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials.

Response to Comment on "Knight SR, et al.: The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer" (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). Response to Comment on "Knight SR, et al.: The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer". Annals of Surgery, 270(6), e128-e129. https://doi.org/10.1097/SLA.0000000000003340