Outputs (4)

Mitotic activity of survivin is regulated by acetylation at K129 (2015)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (2015). Mitotic activity of survivin is regulated by acetylation at K129. Cell Cycle, 14(11), https://doi.org/10.1080/15384101.2015.1033597

Survivin is a cancer-associated protein regulated by multiple factors, including acetylation at K129 within its C-terminal alpha-helical tail. Acetylation of survivin is being pursued as a potential prognostic marker in breast cancer. This modificat... Read More about Mitotic activity of survivin is regulated by acetylation at K129.

The functional repertoire of survivin's tails (2015)
Journal Article
Wheatley, S. P. (2015). The functional repertoire of survivin's tails. Cell Cycle, 14(2), https://doi.org/10.4161/15384101.2014.979680

Survivin is a multitasking protein that can inhibit cell death and that is essential for mitosis. Due to these prosurvival activities and the correlation of its expression with tumour resistance to conventional cancer treatments, survivin has receive... Read More about The functional repertoire of survivin's tails.

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer (2014)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (in press). Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer. Cancer Cell International, 14, Article 78. https://doi.org/10.1186/s12935-014-0078-8

Background
Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essentia... Read More about Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer.

Nuclear survivin: cellular consequences and therapeutic implications (2011)
Book Chapter
Wheatley, S. P. (2011). Nuclear survivin: cellular consequences and therapeutic implications. In H. Gali-Muhtasib (Ed.), Advances in cancer therapy. InTech. https://doi.org/10.5772/24795

The great deluge algorithm explores neighbouring solutions which are accepted if they are better than the best solution so far or if the detriment in quality is no larger than the current water level. In the original great deluge method, the water le... Read More about Nuclear survivin: cellular consequences and therapeutic implications.