Outputs (6)

Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Cox, E., Hoad, C., …Spiller, R. C. (in press). Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI. American Journal of Gastroenterology, https://doi.org/10.1038/ajg.2016.538

OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IB... Read More about Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI.

Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities (2016)
Journal Article
Hens, B., Corsetti, M., Spiller, R. C., Marciani, L., Vanuytsel, T., Tack, J., …Augustijns, P. (2017). Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519(1-2), https://doi.org/10.1016/j.ijpharm.2016.11.063

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i... Read More about Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities.

Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat (2016)
Journal Article
Eldeghaidy, S., Marciani, L., Hort, J., Hollowood, T. A., Singh, G., Bush, D., …Francis, S. T. (2016). Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat. Journal of Nutrition, 146(11), 2187-2198. https://doi.org/10.3945/jn.116.234104

Background: Consumption of fat is regulated by reward and homeostatic pathways, but no studies have examined the role of the intake of a high fat meal (HFM) on subsequent brain activation to oral stimuli. Objective: We evaluated how prior consumptio... Read More about Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat.

Patients with chronic kidney disease have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy: small bowel dysfunction in CKD (2016)
Journal Article
Grant, C. J., Harrison, L. E., Hoad, C. L., Marciani, L., Gowland, P. A., & McIntyre, C. W. (2017). Patients with chronic kidney disease have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy: small bowel dysfunction in CKD. Journal of Gastroenterology and Hepatology, 32(2), 372-377. https://doi.org/10.1111/jgh.13458

Background and Aim: Chronic kidney disease (CKD) affects gastrointestinal (GI) function and results in numerous adaptive and maladaptive responses. Disruption of the colonic microbiome and its attendant consequences—the loss of gut barrier integrity... Read More about Patients with chronic kidney disease have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy: small bowel dysfunction in CKD.

Anticipation of thermal pain in diverticular disease (2016)
Journal Article
Smith, J. K., Marciani, L., Humes, D. J., Francis, S. T., Gowland, P. A., & Spiller, R. C. (2016). Anticipation of thermal pain in diverticular disease. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12790

Background The relative importance of peripheral nerve injury or differences in central pain processing in painful diverticular disease (DD) is unclear. Functional MRI has demonstrated changes in the anticipation of pain in irritable bowel syndrom... Read More about Anticipation of thermal pain in diverticular disease.

Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Paul, J., Cox, E., …Spiller, R. C. (2016). Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12784

Background Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal vol... Read More about Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation.