A distinct bacterial dysbiosis associated skin inflammation in ovine footrot

Maboni, G.; Blanchard, Adam M.; Frosth, S.; Stewart, Ceri E.; Emes, Richard D.; T�temeyer, Sabine

Abstract

Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma(29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.

Citation

Maboni, G., Blanchard, A. M., Frosth, S., Stewart, C. E., Emes, R. D., & Tötemeyer, S. (in press). A distinct bacterial dysbiosis associated skin inflammation in ovine footrot. Scientific Reports, 7, Article 45220. https://doi.org/10.1038/srep45220

• Journal Article Type: Article
• Acceptance Date: Feb 2, 2017
• Online Publication Date: Mar 24, 2017
• Deposit Date: Mar 28, 2017
• Publicly Available Date: Mar 28, 2017
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Article Number: 45220
• DOI: https://doi.org/10.1038/srep45220
• Public URL: https://nottingham-repository.worktribe.com/output/852261
• Publisher URL: http://www.nature.com/articles/srep45220
• Contract Date: Mar 28, 2017