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A distinct bacterial dysbiosis associated skin inflammation in ovine footrot

Maboni, G.; Blanchard, Adam M.; Frosth, S.; Stewart, Ceri E.; Emes, Richard D.; T�temeyer, Sabine

A distinct bacterial dysbiosis associated skin inflammation in ovine footrot Thumbnail


Authors

G. Maboni

S. Frosth

Ceri E. Stewart

Richard D. Emes



Abstract

Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1? and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma(29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.

Journal Article Type Article
Acceptance Date Feb 2, 2017
Online Publication Date Mar 24, 2017
Deposit Date Mar 28, 2017
Publicly Available Date Mar 28, 2017
Journal Scientific Reports
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Article Number 45220
DOI https://doi.org/10.1038/srep45220
Public URL https://nottingham-repository.worktribe.com/output/852261
Publisher URL http://www.nature.com/articles/srep45220

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