Tianye Jia
Neural basis of reward anticipation and its genetic determinants
Jia, Tianye; Macare, Christine; Desrivi�res, Sylvane; Gonzalez, Dante A.; Tao, Chenyang; Ji, Xiaoxi; Ruggeri, Barbara; Nees, Frauke; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L. W.; Bromberg, Uli; B�chel, Christian; Conrod, Patricia J.; Dove, Rachel; Frouin, Vincent; Gallinat, J�rgen; Garavan, Hugh; Gowland, Penny A.; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lemaitre, Herv�; Martinot, Jean-Luc; Paus, Tom�; Pausova, Zdenka; Poline, Jean-Baptiste; Rietschel, Marcella; Robbins, Trevor; Smolka, Michael N.; M�ller, Christian P.; Feng, Jianfeng; Rothenfluh, Adrian; Flor, Herta; Schumann, Gunter
Authors
Christine Macare
Sylvane Desrivi�res
Dante A. Gonzalez
Chenyang Tao
Xiaoxi Ji
Barbara Ruggeri
Frauke Nees
Tobias Banaschewski
Gareth J. Barker
Arun L. W. Bokde
Uli Bromberg
Christian B�chel
Patricia J. Conrod
Rachel Dove
Vincent Frouin
J�rgen Gallinat
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Mark Lathrop
Herv� Lemaitre
Jean-Luc Martinot
Tom� Paus
Zdenka Pausova
Jean-Baptiste Poline
Marcella Rietschel
Trevor Robbins
Michael N. Smolka
Christian P. M�ller
Jianfeng Feng
Adrian Rothenfluh
Herta Flor
Gunter Schumann
Abstract
Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
Citation
Jia, T., Macare, C., Desrivières, S., Gonzalez, D. A., Tao, C., Ji, X., …Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113(14), 3879-3884. https://doi.org/10.1073/pnas.1503252113
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 11, 2016 |
Online Publication Date | Mar 21, 2016 |
Publication Date | Apr 5, 2016 |
Deposit Date | May 9, 2017 |
Journal | Proceedings of the National Academy of Sciences |
Print ISSN | 0027-8424 |
Electronic ISSN | 1091-6490 |
Publisher | National Academy of Sciences |
Peer Reviewed | Peer Reviewed |
Volume | 113 |
Issue | 14 |
Pages | 3879-3884 |
DOI | https://doi.org/10.1073/pnas.1503252113 |
Public URL | https://nottingham-repository.worktribe.com/output/786394 |
Publisher URL | http://www.pnas.org/content/113/14/3879 |
Contract Date | May 9, 2017 |
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