Brad Ebanks
The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise
Ebanks, Brad; Ingram, Thomas L.; Katyal, Gunjan; Ingram, John R.; Moisoi, Nicoleta; Chakrabarti, Lisa
Authors
Thomas L. Ingram
Gunjan Katyal
John R. Ingram
Nicoleta Moisoi
LISA CHAKRABARTI LISA.CHAKRABARTI@NOTTINGHAM.AC.UK
Professor of Mitochondrial Biology
Abstract
One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may enhance synaptic plasticity, protect against neuro-inflammation and modulate L-Dopa regulated signalling pathways. We explored the effects of exercise on Pink1 deficient Drosophila melanogaster which undergo neurodegeneration and muscle degeneration. We used a ‘power-tower’ type exercise platform to deliver exercise activity to Pink1- and age matched wild-type Drosophila. Mitochondrial proteomic profiles responding to exercise were obtained. Of the 516 proteins identified, 105 proteins had different levels between Pink1- and wild-type non-exercised Drosophila. Gene ontology enrichment analysis and STRING network analysis highlighted proteins and pathways with altered expression within the mitochondrial proteome. Comparison of the Pink1- exercised proteome to wild-type proteomes showed that exercising the Pink1- Drosophila caused their proteomic profile to return towards wild-type levels.
Citation
Ebanks, B., Ingram, T. L., Katyal, G., Ingram, J. R., Moisoi, N., & Chakrabarti, L. (2021). The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise. Aging, 13(11), 14709-14728. https://doi.org/10.18632/aging.203128
Journal Article Type | Article |
---|---|
Acceptance Date | May 20, 2021 |
Online Publication Date | Jun 1, 2021 |
Publication Date | Jun 15, 2021 |
Deposit Date | Jun 3, 2021 |
Publicly Available Date | Jun 3, 2021 |
Journal | Aging |
Electronic ISSN | 1945-4589 |
Publisher | Impact Journals |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 11 |
Pages | 14709-14728 |
DOI | https://doi.org/10.18632/aging.203128 |
Public URL | https://nottingham-repository.worktribe.com/output/5623816 |
Publisher URL | https://www.aging-us.com/article/203128/text |
Files
aging-v13iundefined-203128
(1.3 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/3.0/
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