Outputs (495)

Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England (2023)
Journal Article
Morton, A. J., Simpson, A., & Humes, D. J. (2024). Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England. Techniques in Coloproctology, 28(1), Article 9. https://doi.org/10.1007/s10151-023-02874-3

Background: Laparoscopic and now robotic colorectal surgery has rapidly increased in prevalence; however, little is known about how uptake varies by region and sociodemographics. The aim of this study was to quantify the uptake of minimally invasive... Read More about Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England.

Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease (2023)
Journal Article
Munir, T., Cairns, D. A., Bloor, A., Allsup, D., Cwynarski, K., Pettitt, A., Paneesha, S., Fox, C. P., Eyre, T. A., Forconi, F., Elmusharaf, N., Kennedy, B., Gribben, J., Pemberton, N., Sheehy, O., Preston, G., Schuh, A., Walewska, R., Duley, L., Howard, D., …Hillmen, P. (2024). Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease. New England Journal of Medicine, 390(4), 326-337. https://doi.org/10.1056/nejmoa2310063

BACKGROUND: The combination of ibrutinib and venetoclax has been shown to improve outcomes in patients with chronic lymphocytic leukemia (CLL) as compared with chemoimmunotherapy. Whether ibrutinib-venetoclax and personalization of treatment duration... Read More about Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease.

Richter's transformation: Transforming the clinical landscape (2023)
Journal Article
Barrett, A., Appleby, N., Dreau, H., Fox, C., Munir, T., & Eyre, T. (2024). Richter's transformation: Transforming the clinical landscape. Blood Reviews, 64, Article 101163. https://doi.org/10.1016/j.blre.2023.101163

Richter transformation (RT) represents an aggressive histological transformation from chronic lymphocytic leukaemia, most often to a large B cell lymphoma. It is characterised by chemo-resistance and subsequent short survival. Drug development has st... Read More about Richter's transformation: Transforming the clinical landscape.

The amino acid transporter SLC7A11 expression in breast cancer (2023)
Journal Article
Nath, P., Alfarsi, L. H., El-Ansari, R., Masisi, B. K., Erkan, B., Fakroun, A., …Green, A. R. (2024). The amino acid transporter SLC7A11 expression in breast cancer. Cancer Biology and Therapy, 25(1), Article 2291855. https://doi.org/10.1080/15384047.2023.2291855

Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies. Metabolic reprogramming, a defining characteristic of cancer, has emer... Read More about The amino acid transporter SLC7A11 expression in breast cancer.

Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke (2023)
Journal Article
Kadir, R. R. A., Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke. Scientific Reports, 13(1), Article 21843. https://doi.org/10.1038/s41598-023-48907-7

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke.

Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
ABDULKADIR, R., RAKKAR, K., OTHMAN, O., SPRIGG, N., BATH, P., & BAYRAKTUTAN, U. (2023). Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Scientific Reports, 13, Article 21843. https://doi.org/10.1038/s41598-023-48907-7

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

An examination of resting-state functional connectivity in patients with active Crohn’s disease (2023)
Journal Article
Thapaliya, G., Eldeghaidy, S., Radford, S. J., Francis, S. T., & Moran, G. W. (in press). An examination of resting-state functional connectivity in patients with active Crohn’s disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-net... Read More about An examination of resting-state functional connectivity in patients with active Crohn’s disease.

An examination of resting-state functional connectivity in patients with active Crohn's disease (2023)
Journal Article
Francis, S. T., Moran, G. W., Eldeghaidy, S., Radford, S., & Thapaliya, G. (2023). An examination of resting-state functional connectivity in patients with active Crohn's disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-net... Read More about An examination of resting-state functional connectivity in patients with active Crohn's disease.

Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource (2023)
Journal Article
Kapizioni, C., Desoki, R., Lam, D., Balendran, K., Al-Sulais, E., Subramanian, S., …Raine, T. (2024). Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource. Journal of Crohn's and Colitis, 18(6), 790-800. https://doi.org/10.1093/ecco-jcc/jjad203

Background and Aims
To compare effectiveness of different biologic therapies and sequences in patients with Inflammatory Bowel Disease (IBD) using real-world data from a large cohort with long exposure.

Methods
Demographic, disease, treatment an... Read More about Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource.

Impact of MYC and BCL2 double expression on outcomes in primary CNS lymphoma: a UK multicenter analysis (2023)
Journal Article
Poynton, E., Chernucha, E., Day, J. W., Prodger, C., Hopkins, D., Rakesh, P., O'Neill, T., Thakrar, N., Akarca, A., Jamal, E., Ali, A. S., Kirkwood, A. A., Pomplun, S., Marafioti, T., Calaminici, M., Kirkwood, A. A., Greaves, P., Chaganti, S., McKay, P., Smith, J., …Okosun, J. (2024). Impact of MYC and BCL2 double expression on outcomes in primary CNS lymphoma: a UK multicenter analysis. Blood Advances, 8(7), 1772–1775. https://doi.org/10.1182/bloodadvances.2023011426