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Outputs (495)

Kidney Beam - a cost-effective digital intervention to improve mental health (2024)
Journal Article
Greenwood, S. A., Briggs, J., Walklin, C., Mangahis, E., Young, H. M., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P., Haggis, L., Hamilton, A., Jesky, M., …Macdonald, J. (in press). Kidney Beam - a cost-effective digital intervention to improve mental health. Kidney International Reports,

Background: There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health interv... Read More about Kidney Beam - a cost-effective digital intervention to improve mental health.

Intra- and interindividual variability in fasted gastric content volume (2024)
Journal Article
Roelofs, J. J., Camps, G., Leenders, L. M., Marciani, L., Spiller, R. C., van Eijnatten, E. J., Alyami, J., Denga, R., Freitas, D., Grimm, M., Karhunen, L. J., Krishnasamy, S., Le Feunteung, S., Lobo, D. N., Mackiei, A. R., Mayar, M., Weitschies, W., & Smeets, P. A. (2024). Intra- and interindividual variability in fasted gastric content volume. Neurogastroenterology and Motility, Article e14904. https://doi.org/10.1111/nmo.14904

Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual... Read More about Intra- and interindividual variability in fasted gastric content volume.

Intra‐ and interindividual variability in fasted gastric content volume (2024)
Journal Article
Roelofs, J. J. M., Camps, G., Leenders, L. M., Marciani, L., Spiller, R. C., Van Eijnatten, E. J. M., Alyami, J., Deng, R., Freitas, D., Grimm, M., Karhunen, L. J., Krishnasamy, S., Le Feunteun, S., Lobo, D. N., Mackie, A. R., Mayar, M., Weitschies, W., & Smeets, P. A. M. (in press). Intra‐ and interindividual variability in fasted gastric content volume. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14904

Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra-and interindividual... Read More about Intra‐ and interindividual variability in fasted gastric content volume.

Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group (2024)
Journal Article
Rakkar, K., Kadir, R. R. A., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2024). Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-024-10777-5

Endothelial progenitor cells (EPCs) are stem cells that can repair injured blood vessels through neovascularisation. This is achieved through secretion of growth factors and endothelial maturation. EPC numbers and function have been studied to determ... Read More about Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group.

The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)—A Systematic Review and Meta-Analysis (2024)
Journal Article
Alenezi, S. A., Elkmeshi, N., Alanazi, A., Alanazi, S. T., Khan, R., & Amer, S. (2024). The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)—A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 13(16), Article 4934. https://doi.org/10.3390/jcm13164934

Background: Currently, the primary strategy for addressing polycystic ovarian syndrome (PCOS) involves lifestyle modifications, with a focus on weight loss. The purpose of this meta-analysis was to assess the impact of weight loss through dietary int... Read More about The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)—A Systematic Review and Meta-Analysis.

Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results (2024)
Journal Article
Ligori Malcolm, F., Yapa, A. K., Wong, Z. Y., Morton, A. J., Crooks, C., West, J., Banerjea, A., & Humes, D. (2024). Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results. Alimentary Pharmacology and Therapeutics, https://doi.org/10.1111/apt.18208


Background

Faecal haemoglobin (f-Hb) testing is used in colorectal cancer (CRC) screening and increasingly to guide the investigation in patients with symptoms suggestive of CRC. Studies have demonstrated increased mortality with raised f-Hb.... Read More about Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results.

Optimizing kidney and cardiovascular protection in an era of multiple effective treatments (2024)
Journal Article
Taal, M. W. (2024). Optimizing kidney and cardiovascular protection in an era of multiple effective treatments. Current Opinion in Nephrology and Hypertension, https://doi.org/10.1097/MNH.0000000000001019

Purpose of review After decades of relying on the control of hypertension and treatment with renin angiotensin system inhibitors as the only evidence-based interventions to slow the progression of chronic kidney disease (CKD), we have entered an era... Read More about Optimizing kidney and cardiovascular protection in an era of multiple effective treatments.

Exploring the acceptability of and adherence to prehabilitation and rehabilitation in patients undergoing major abdominal surgery: A systematic review and meta-analysis (2024)
Journal Article
Alsuwaylihi, A., Skořepa, P., Prado, C. M., Gomez, D., Lobo, D. N., & O'Connor, D. (2024). Exploring the acceptability of and adherence to prehabilitation and rehabilitation in patients undergoing major abdominal surgery: A systematic review and meta-analysis. Clinical Nutrition ESPEN, 63, 709-726. https://doi.org/10.1016/j.clnesp.2024.07.1060

Background and aims: Prehabilitation combines exercise, nutritional, and psychological interventions administered before surgery to improve patient outcomes. This comprehensive review and meta-analysis examined the feasibility, adherence, and effecti... Read More about Exploring the acceptability of and adherence to prehabilitation and rehabilitation in patients undergoing major abdominal surgery: A systematic review and meta-analysis.

The role of the ALKBH5 RNA demethylase in invasive breast cancer (2024)
Journal Article
Woodcock, C. L., Alsaleem, M., Toss, M. S., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Blatt, N., Rizvanov, A. A., Miftakhova, R. R., Kariri, Y. A., Madhusudan, S., Green, A. R., Rutland, C. S., Fray, R. G., Rakha, E. A., & Mongan, N. P. (2024). The role of the ALKBH5 RNA demethylase in invasive breast cancer. Discover Oncology, 15(1), Article 343. https://doi.org/10.1007/s12672-024-01205-8

Background: N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological mechanism... Read More about The role of the ALKBH5 RNA demethylase in invasive breast cancer.