Outputs (519)

Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells (2024)
Journal Article
Alhazmi, A., Sidney, L. E., Hopkinson, A., & Elsheikha, H. M. (2024). Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells. Acta Tropica, 257, Article 107288. https://doi.org/10.1016/j.actatropica.2024.107288

Soluble factors in the secretome of Acanthamoeba castellanii play crucial roles in the pathogenesis of Acanthamoeba keratitis (AK). Investigating the pathological effects of A. castellanii-derived conditioned medium (ACCM) on ocular cells can provide... Read More about Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells.

ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment (2024)
Journal Article
Adamina, M., Minozzi, S., Warusavitarne, J., Buskens, C., Chaparro, M., Verstockt, B., Kopylov, U., Agrawal, M., Allocca, M., Atreya, R., Battat, R., Bettenworth, D., Bislenghi, G., Brown, S. R., Burisch, J., Casanova, M. J., Czuber-Dochan, W., de Groof, J., El-Hussuna, A., Ellul, P., …Myrelid, P. (2024). ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment. Journal of Crohn's and Colitis, https://doi.org/10.1093/ecco-jcc/jjae089

This article is the second in a series of two publications on the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease. The first article covers medical management; the present article address... Read More about ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment.

Real-world clinical effectiveness of ustekinumab in the treatment of Crohn’s disease in the East Midlands UK (2024)
Journal Article
White, J. R., Ahmad, S., Ashraf, F., Foley, S., Din, S., Das, R. K., Charles, N. M., Pinheiro, J., Palejwala, A., Wright, P., Andiappan, M., Alexander, M., Uddin, B., Hoshen, D., Elphick, D., Qamar, T., Rezwan, N., Hamza, M. V., Glover, J., Robinson, R., …Moran, G. (2024). Real-world clinical effectiveness of ustekinumab in the treatment of Crohn’s disease in the East Midlands UK. Frontline Gastroenterology, 15(5), 359-365. https://doi.org/10.1136/flgastro-2024-102718

Objectives: To evaluate the effectiveness of ustekinumab in treating Crohn’s disease (CD) in a UK real-world setting.

Design: This was a multicentre, retrospective observational study of patients (aged ≥18 years) with CD or inflammatory bowel dise... Read More about Real-world clinical effectiveness of ustekinumab in the treatment of Crohn’s disease in the East Midlands UK.

Nottingham Prognostic x (NPx): a risk stratification tool in ER-positive HER2-negative breast cancer: A validation study (2024)
Journal Article
Lashen, A. G., Toss, M., Miligy, I., Rewcastle, E., Kiraz, U., Janssen, E. A. M., Green, A. R., Quinn, C., Ellis, I., & Rakha, E. (2024). Nottingham Prognostic x (NPx): a risk stratification tool in ER-positive HER2-negative breast cancer: A validation study. Histopathology, 85(3), 468-477. https://doi.org/10.1111/his.15234

Aims
In this study, we validate the use of Nottingham Prognostic x (NPx), consisting of tumour size, tumour grade, progesterone receptor (PR) and Ki67 in luminal BC.

Materials and methods
Two large cohorts of luminal early-stage BC (n = 2864) we... Read More about Nottingham Prognostic x (NPx): a risk stratification tool in ER-positive HER2-negative breast cancer: A validation study.

ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer (2024)
Journal Article
Patel, R., Alfarsi, L. H., El-Ansari, R., Masisi, B. K., Erkan, B., Fakroun, A., …Green, A. R. (in press). ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer. Pathobiology, https://doi.org/10.1159/000539564

Purpose: ATF4, a stress-responsive transcription factor that upregulates adaptive genes, is a potential prognostic marker and modulator of glutamine metabolism in breast cancer. However, its exact role remains to be elucidated.

Methods: ATF4 expre... Read More about ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer.

Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort) (2024)
Journal Article
Hopkins, G., Gomez, N., Tucis, D., Bartlett, L., Steers, G., Burns, E., Brown, M., Harvey-Cowlishaw, T., Santos, R., Lauder, S. N., Scurr, M., Capitani, L., Burnell, S., Rees, T., Smart, K., Somerville, M., Gallimore, A., Perera, M., Potts, M., Metaxaki, M., …Fairclough, L. (2024). Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort). Journal of Clinical Immunology, 44(6), Article 147. https://doi.org/10.1007/s10875-024-01739-0

Purpose
Asymptomatic SARS-CoV-2 infections were widely reported during the COVID-19 pandemic, acting as a hidden source of infection. Many existing studies investigating asymptomatic immunity failed to recruit true asymptomatic individuals. Thus, we... Read More about Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort).

Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study (2024)
Journal Article
Dupuis, J., Bachy, E., Morschhauser, F., Cartron, G., Fukuhara, N., Daguindau, N., Casasnovas, R.-O., Snauwaert, S., Gressin, R., Fox, C. P., d'Amore, F. A., Staber, P. B., Tournilhac, O., Bouabdallah, K., Thieblemont, C., André, M., Rai, S., Ennishi, D., Gkasiamis, A., Nishio, M., …Lemonnier, F. (2024). Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study. Lancet Haematology, 11(6), e406-e414. https://doi.org/10.1016/S2352-3026%2824%2900102-9

Follicular helper T-cell lymphomas (TFHL) harbour frequent alterations in genes that regulate DNA methylation. Preliminary reports suggest that treatment with 5-azacitidine has clinical activity in patients with relapsed or refractory TFHL. We aimed... Read More about Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study.

The characteristics and prognostic significance of histone H1 expression in breast cancer (2024)
Journal Article
Lashen, A. G., Almalki, N., Toss, M., Mirza, S., Malki, M. I., Rutland, C. S., Jeyapalan, J. N., Green, A. R., Mongan, N. P., Madhusudan, S., & Rakha, E. A. (2024). The characteristics and prognostic significance of histone H1 expression in breast cancer. Pathology, 56(6), 826-833. https://doi.org/10.1016/j.pathol.2024.03.012

Histone H1 (H.H1) is involved in chromatin organisation and gene regulation and is overexpressed in many malignant tumours, including breast cancer (BC). This study proposed and evaluated the prognostic role of H.H1 expression in BC.

H.H1 mRNA exp... Read More about The characteristics and prognostic significance of histone H1 expression in breast cancer.

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status (2024)
Journal Article
Saikumar Jayalatha, A. K., Ketelaar, M. E., Hesse, L., Badi, Y. E., Zounemat-Kermani, N., Sharon, B., Dijk, N. F., van den Berge, M., Guryev, V., Sayers, I., Vonk, J. E., Adcock, I. M., Koppelman, G. H., & Nawijn, M. C. (2024). IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status. European Respiratory Journal, 63(6), Article 2400005. https://doi.org/10.1183/13993003.00005-2024

Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine (2024)
Journal Article
Bayraktutan, H., Symonds, P., Brentville, V. A., Moloney, C., Galley, C., Bennett, C. L., Mata, A., Durrant, L., Alexander, C., & Gurnani, P. (2024). Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine. Biomaterials, 311, Article 122647. https://doi.org/10.1016/j.biomaterials.2024.122647

DNA technology has emerged as a promising route to accelerated manufacture of sequence agnostic vaccines. For activity, DNA vaccines must be protected and delivered to the correct antigen presenting cells. However, the physicochemical properties of t... Read More about Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine.