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Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life (2019)
Journal Article
Abubara, K., Ye, M., McCulloch, C. E., Sullivan, A., Margolis, D. J., Strachan, D. P., …Langan, S. M. (2019). Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life. Journal of Allergy and Clinical Immunology, 144(3), 710–719. https://doi.org/10.1016/j.jaci.2019.05.040

Background
Atopic eczema onset is described primarily in early childhood; the frequency and characteristics of adult-onset disease remain controversial.
Objective
To determine the proportion of individuals who report atopic eczema symptoms between... Read More about Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life.

Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community (2019)
Journal Article
Chalmers, J., Wilkes, E., Harris, R., Kent, L., Kinra, S., Aithal, G., …Guha, I. N. (2020). Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community. Frontline Gastroenterology, 11(2), 86-92. https://doi.org/10.1136/flgastro-2019-101177

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Objective: To describe the development of the Nottingham liver disease stratification pathway, present a 12-month evaluation of uptake and stratification results... Read More about Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community.

Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review (2019)
Journal Article
Booth, V., Harwood, R. H., Hancox, J. E., Hood-Moore, V., Masud, T., & Logan, P. (2019). Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review. BMJ Open, 9(6), Article e024982. https://doi.org/10.1136/bmjopen-2018-024982

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Objectives This review aimed to identify mechanisms underlying participation in falls prevention interventions, in older adults with cognitive impairment. In par... Read More about Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review.

Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review (2019)
Journal Article
Sevilla, C., Goody, J., Baguley, D. M., & Kasbekar, A. V. (2019). Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review. Journal of Laryngology and Otology, 133(6), 450-456. https://doi.org/10.1017/S002221511900094X

Background: Ménière’s Disease (MD) often presents with aural fullness, for reasons that are currently not well understood. Insertion of transtympanic ventilation tubes (VTs) has been historically used for the management of this symptom, though the na... Read More about Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review.

A prospective study examining cachexia predictors in patients with incurable cancer (2019)
Journal Article
Vagnildhaug, O. M., Brunelli, C., Hjermstad, M. J., Strasser, F., Baracos, V., Wilcock, A., …Solheim, T. S. (2019). A prospective study examining cachexia predictors in patients with incurable cancer. BMC Palliative Care, 18, Article 46. https://doi.org/10.1186/s12904-019-0429-2

© 2019 The Author(s). Background: Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based on these... Read More about A prospective study examining cachexia predictors in patients with incurable cancer.

Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation (2019)
Journal Article
Takwoingi, Y., Whitworth, H., Rees-Roberts, M., Badhan, A., Partlett, C., Green, N., Boakye, A., Lambie, H., Marongiu, L., Jit, M., White, P., Deeks, J. J., Kon, O. M., Lalvani, A., & Interferon Gamma Release Assays for Diagnostic Evaluation of Active Tuberculosis (IDEA) study group. (2019). Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation. Health Technology Assessment, 23(23), 1-184. https://doi.org/10.3310/hta23230

© Queen’s Printer and Controller of HMSO 2019. Background: Interferon gamma release assays (IGRAs) are blood tests recommended for the diagnosis of tuberculosis (TB) infection. There is currently uncertainty about the role and clinical utility of IGR... Read More about Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.

Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study (2019)
Journal Article
Snowden, J. A., Hawkey, C., Hind, D., Swaby, L., Mellor, K., Emsley, R., …European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP). (2019). Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterology, 19, Article 82. https://doi.org/10.1186/s12876-019-0992-2

Background
Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and significant health care costs.... Read More about Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study.

Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients (2019)
Journal Article
Boereboom, C. L., Blackwell, J. E., Williams, J. P., Phillips, B. E., & Lund, J. N. (2019). Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients. Scandinavian Journal of Medicine and Science in Sports, 29(9), 1383-1391. https://doi.org/10.1111/sms.13460

Background: Preoperative cardiorespiratory fitness (CRF) in colorectal cancer patients has been shown to affect postoperative outcomes. The aim of this study was to test the feasibility of high-intensity interval training (HIT) for improving fitness... Read More about Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste (2019)
Journal Article
Smith, S. J., Tyler, B., Gould, T. W., Veal, G. J., Gorelick, N. L., Rowlinson, J., …Rahman, R. (2019). Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste. Clinical Cancer Research, 25(16), 5094-5106. https://doi.org/10.1158/1078-0432.ccr-18-3850

Purpose: High-grade glioma (HGG) treatment is limited by the inability of otherwise potentially efficacious drugs to penetrate the blood brain barrier. We evaluate the unique intra-cavity delivery mode and translational potential of a blend of poly(D... Read More about Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste.