Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life

Abubara, Katrina; Ye, Morgan; McCulloch, Charles E.; Sullivan, Alice; Margolis, David J.; Strachan, David P.; Paternoster, Lavinia; Yew, Yik Weng; Williams, Hywel C.; Langan, Sin�ad M.

Abstract

Background
Atopic eczema onset is described primarily in early childhood; the frequency and characteristics of adult-onset disease remain controversial.
Objective
To determine the proportion of individuals who report atopic eczema symptoms between birth and mid adulthood, and to examine demographic, immunologic, and genetic factors associated with period of symptom onset.
Methods
We conducted a longitudinal study using data from two nationally representative community-based birth cohorts from the United Kingdom: the British Cohort Studies 1958 and 1970. Individuals were followed from birth through age 42-50. The primary outcome was the age period of self-reported atopic eczema symptom onset based on repeated measures of self-reported atopic eczema at each survey wave.
Results
The annual period prevalence of atopic eczema ranged from 5-15% in two cohorts of over 17,000 participants each followed from birth through mid-age. There was no clear trend in prevalence by age, and among adults reporting active atopic eczema during a given year, only 38% had symptom onset reported in childhood. When compared with individuals whose eczema started in childhood, those with adult-onset disease were more likely to be women, from Scotland or Northern England, of lower childhood socio-economic group, smokers in adulthood, and less likely to have a history of asthma. In a sub-analysis using data from the 1958 cohort only, genetic mutations previously associated with atopic eczema, including filaggrin null mutations, and allergen-specific IgE were more common among those with childhood-onset disease.
Conclusion
Rates of self-reported atopic eczema remain high after childhood, and adult-onset atopic eczema has different risk factor associations than childhood-onset eczema.

Citation

Abubara, K., Ye, M., McCulloch, C. E., Sullivan, A., Margolis, D. J., Strachan, D. P., Paternoster, L., Yew, Y. W., Williams, H. C., & Langan, S. M. (2019). Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life. Journal of Allergy and Clinical Immunology, 144(3), 710–719. https://doi.org/10.1016/j.jaci.2019.05.040

• Journal Article Type: Article
• Acceptance Date: May 31, 2019
• Online Publication Date: Jun 28, 2019
• Publication Date: Sep 30, 2019
• Deposit Date: Jun 6, 2019
• Publicly Available Date: Jun 29, 2020
• Journal: Journal of Allergy and Clinical Immunology
• Print ISSN: 0091-6749
• Electronic ISSN: 1097-6825
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 144
• Issue: 3
• Pages: 710–719
• DOI: https://doi.org/10.1016/j.jaci.2019.05.040
• Keywords: Atopic eczema; Atopic dermatitis; Natural history; Epidemiology
• Public URL: https://nottingham-repository.worktribe.com/output/2149407
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0091674919308279
• Additional Information: This article is maintained by: Elsevier; Article Title: Clinical onset of atopic eczema: Results from 2 nationally representative British birth cohorts followed through midlife; Journal Title: Journal of Allergy and Clinical Immunology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jaci.2019.05.040; Content Type: article; Copyright: © 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
• Contract Date: Jun 6, 2019