Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons (2018)
Journal Article
Geiszler, P. C., Ugun-Klusek, A., Lawler, K., Pardon, M.-C., Yuchun, D., Bai, L., …Bedford, L. (in press). Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Scientific Reports, 8, Article 4833. https://doi.org/10.1038/s41598-018-23155-2

Metabolite profiling is an important tool that may better capture the multiple features of neurodegeneration. With the considerable parallels between mouse and human metabolism, the use of metabolomics in mouse models with neurodegenerative pathology... Read More about Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons.

Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis (2018)
Journal Article
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018). Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159(5), https://doi.org/10.1097/j.pain.0000000000001209

Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience... Read More about Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.

The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction (2018)
Journal Article
Makropoulos, A., Robinson, E. C., Schuh, A., Wright, R., Fitzgibbon, S., Bozek, J., …Rueckert, D. (2018). The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction. NeuroImage, 173, 88-112. https://doi.org/10.1101/125526

The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following est... Read More about The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction.

Patterns of grey matter loss associated with motor subscores in early Parkinson's disease (2017)
Journal Article
Li, X., Xing, Y., Martin-Bastida, A., Piccini, P., & Auer, D. P. (in press). Patterns of grey matter loss associated with motor subscores in early Parkinson's disease. NeuroImage: Clinical, 17, https://doi.org/10.1016/j.nicl.2017.11.009

Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether... Read More about Patterns of grey matter loss associated with motor subscores in early Parkinson's disease.

Improved tractography using asymmetric fibre orientation distributions (2017)
Journal Article
Bastiani, M., Cottaar, M., Dikranian, K., Ghosh, A., Zhang, H., Alexander, D. C., …Sotiropoulos, S. N. (2017). Improved tractography using asymmetric fibre orientation distributions. NeuroImage, 158, https://doi.org/10.1016/j.neuroimage.2017.06.050

Diffusion MRI allows us to make inferences on the structural organisation of the brain by mapping water diffusion to white matter microstructure. However, such a mapping is generally ill-defined; for instance, diffusion measurements are antipodally s... Read More about Improved tractography using asymmetric fibre orientation distributions.

Time-efficient and flexible design of optimized multishell HARDI diffusion (2017)
Journal Article
Hutter, J., Tournier, J. D., Price, A. N., Cordero-Grande, L., Hughes, E. J., Malik, S., …Hajnal, J. V. (2018). Time-efficient and flexible design of optimized multishell HARDI diffusion. Magnetic Resonance in Medicine, 79(3), 1276-1292. https://doi.org/10.1002/mrm.26765

Purpose: Advanced diffusion magnetic resonance imaging benefits from collecting as much data as is feasible but is highly sensitive to subject motion and the risk of data loss increases with longer acquisition times. Our purpose was to create a maxim... Read More about Time-efficient and flexible design of optimized multishell HARDI diffusion.