Radical reaction control in the AdoMet radical enzyme CDG Synthase (QueE): consolidate, destabilize, accelerate (2016)
Journal Article
Jäger, C. M., & Croft, A. K. (2017). Radical reaction control in the AdoMet radical enzyme CDG Synthase (QueE): consolidate, destabilize, accelerate. Chemistry - A European Journal, 23(4), https://doi.org/10.1002/chem.201604719

Controlling radical intermediates and thus catalysing and directing complex radical reactions is a central feature of S-adensosylmethionine (SAM)-dependent radical enzymes. We report ab initio and DFT calculations highlighting the specific influence... Read More about Radical reaction control in the AdoMet radical enzyme CDG Synthase (QueE): consolidate, destabilize, accelerate.

Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability (2016)
Journal Article
Karimi, M., Ignasiak, M. T., Chan, B., Croft, A. K., Radom, L., Schiesser, C. H., …Davies, M. J. (2016). Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability. Scientific Reports, 6(1), Article 38572. https://doi.org/10.1038/srep38572

© 2016 The Author(s). Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly associated with loss of protein function and activity. Previous data have suggested that disulfides show only modest reactivity with oxi... Read More about Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability.

Structural elements of an NRPS cyclization domain and its intermodule docking domain (2016)
Journal Article
Dowling, D. P., Kung, Y., Croft, A. K., Taghizadeh, K., Kelly, W. L., Walsh, C. T., & Drennan, C. L. (2016). Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences, 113(44), 12432-12437. https://doi.org/10.1073/pnas.1608615113

Epothilones are thiazole-containing natural products with anticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F. A cyclization domain of EpoB (Cy) assembles the thiazole functio... Read More about Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Three dimensional ink-jet printing of biomaterials using ionic liquids and co-solvents (2016)
Journal Article
Gunasekera, D. H., Kuek, S., Hasanaj, D., He, Y., Tuck, C., Croft, A. K., & Wildman, R. D. (2016). Three dimensional ink-jet printing of biomaterials using ionic liquids and co-solvents. Faraday Discussions, 190, 509-523. https://doi.org/10.1039/C5FD00219B

1-Ethyl-3-methylimidazolium acetate ([C2C1Im][OAc]) and 1-butyl-3-methylimidazolium acetate ([C4C1Im][OAc]) have been used as solvents for the dissolution and ink-jet printing of cellulose from 1.0 to 4.8 wt%, mixed with the co-solvents 1-butanol and... Read More about Three dimensional ink-jet printing of biomaterials using ionic liquids and co-solvents.

Developing energy efficient lignin biomass processing – towards understanding mediator behaviour in ionic liquids (2016)
Journal Article
Eshtaya, M., Ejigu, A., Stephens, G., Walsh, D. A., Chen, G. Z., & Croft, A. K. (2016). Developing energy efficient lignin biomass processing – towards understanding mediator behaviour in ionic liquids. Faraday Discussions, 190, 127-145. https://doi.org/10.1039/c5fd00226e

Environmental concerns have brought attention to the requirement for more efficient and renewable processes for chemicals production. Lignin is the second most abundant natural polymer, and might serve as a sustainable resource for manufacturing fuel... Read More about Developing energy efficient lignin biomass processing – towards understanding mediator behaviour in ionic liquids.