Dr ROB WILKINSON's Outputs (6)

Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish (2019)
Journal Article
Chhabria, K., Vouros, A., Gray, C., MacDonald, R. B., Jiang, Z., Wilkinson, R. N., Plant, K., Vasilaki, E., Howarth, C., & Chico, T. J. (2019). Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Disease Models and Mechanisms, 12(9), Article dmm039867. https://doi.org/10.1242/dmm.039867

Diabetes is associated with dysfunction of the neurovascular unit, although the mechanisms of this are incompletely understood and currently no treatment exists to prevent these negative effects. We previously found that the nitric oxide (NO) donor s... Read More about Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish.

Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish (2019)
Journal Article
Kugler, E. C., Lessen, M., Daetwyler, S., Chhabria, K., Savage, A. M., Silva, V., Plant, K., MacDonald, R. B., Huisken, J., Wilkinson, R. N., Schulte‐Merker, S., Armitage, P., & Chico, T. J. (2019). Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish. EMBO Reports, 20(8), https://doi.org/10.15252/embr.201847047

We identify a novel endothelial membrane behaviour in transgenic zebrafish. Cerebral blood vessels extrude large transient spherical structures that persist for an average of 23 min before regressing into the parent vessel. We term these structures "... Read More about Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish.

The role of endothelial cilia in postembryonic vascular development (2019)
Journal Article
Elworthy, S., Savage, A. M., Wilkinson, R. N., Malicki, J. J., & Chico, T. J. (2019). The role of endothelial cilia in postembryonic vascular development. Developmental Dynamics, 248(6), 410-425. https://doi.org/10.1002/dvdy.40

BACKGROUND:
Cilia are essential for morphogenesis and maintenance of many tissues. Loss-of-function of cilia in early Zebrafish development causes a range of vascular defects, including cerebral hemorrhage and reduced arterial vascular mural cell co... Read More about The role of endothelial cilia in postembryonic vascular development.

TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells (2019)
Journal Article
Arhatte, M., Gunaratne, G. S., El Boustany, C., Kuo, I. Y., Moro, C., Duprat, F., Plaisant, M., Duval, H., Li, D., Picard, N., Couvreux, A., Duranton, C., Rubera, I., Pagnotta, S., Lacas-Gervais, S., Ehrlich, B. E., Marchant, J. S., Savage, A. M., van Eeden, F. J. M., Wilkinson, R. N., …Patel, A. (2019). TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nature Communications, 10(1), Article 2024. https://doi.org/10.1038/s41467-019-10045-y

Mutations in the polycystins cause autosomal dominant polycystic kidney disease (ADPKD). Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel polycystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its o... Read More about TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis (2019)
Journal Article
Savage, A. M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R. B., Kim, H. R., Wilson, H. L., van Eeden, F. J. M., Chico, T. J. A., Armesilla, A. L., & Wilkinson, R. N. (2019). tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10, Article 732. https://doi.org/10.1038/s41467-019-08590-7

Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour of endothelial cells (ECs) as they form vascular networks. Vascular endothelial growth factor (VEGF) is essential for angiogenesis and induces downstream sign... Read More about tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis.

Venous identity requires BMP signalling through ALK3 (2019)
Journal Article
Neal, A., Nornes, S., Payne, S., Wallace, M. D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R. N., Chouliaras, K. M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Chico, T., Bond, G., Bou-Gharios, G., & De Val, S. (2019). Venous identity requires BMP signalling through ALK3. Nature Communications, 10(1), 1-18. https://doi.org/10.1038/s41467-019-08315-w

Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, sugge... Read More about Venous identity requires BMP signalling through ALK3.