Dr ANTO RAJAMANI's Outputs (6)

Next-generation RNA-Sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies (2020)
Journal Article
Rajkumar, A. P., Hye, A., Lange, J., Rashid Manesh, Y., Ballard, C., Fladby, T., & Aarsland, D. (2021). Next-generation RNA-Sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies. American Journal of Geriatric Psychiatry, 29(6), 573-584. https://doi.org/10.1016/j.jagp.2020.10.012

Objectives: There is an urgent clinical need for identifying blood-based diagnostic biomarkers for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA changes in post-mortem DLB brains. Small extracellular vesicles (SEV)... Read More about Next-generation RNA-Sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies.

Perspectives of GCSE students attending a psychiatry summer school in south London (2020)
Journal Article
Wyke, C., de Bernier, G.-L., Lam, C. C. S. F., Holt, C., Butler, S., Rajamani, A. P. R., & Wilson Jones, C. (2021). Perspectives of GCSE students attending a psychiatry summer school in south London. BJPsych Bulletin, 45(2), 114-119. https://doi.org/10.1192/bjb.2020.76

AIMS AND METHOD

To evaluate a pilot psychiatry summer school for GCSE students in terms of participant experience, impact on attitudes to mental illness and perception of psychiatry as a career option. This was performed using the Community Attitu... Read More about Perspectives of GCSE students attending a psychiatry summer school in south London.

Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice (2020)
Journal Article
Rajkumar, A. P., Qvist, P., Donskov, J. G., Lazarus, R., Pallesen, J., Nava, N., Winther, G., Liebenberg, N., La Cour, S. H., Paternoster, V., Fryland, T., Palmfeldt, J., Fejgin, K., Mørk, A., Nyegaard, M., Pakkenberg, B., Didriksen, M., Nyengaard, J. R., Wegener, G., Mors, O., …Børglum, A. D. (2020). Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. Translational Psychiatry, 10(1), Article 239. https://doi.org/10.1038/s41398-020-00914-2

The schizophrenia-associated gene, BRD1, encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health. Alterations in histone modifications and epigenetic regulation contribute to brain transcripto... Read More about Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders (2020)
Journal Article
Ashton, N. J., Hye, A., Rajkumar, A. P., Leuzy, A., Snowden, S., Suárez-Calvet, M., Karikari, T. K., Schöll, M., Joie, R. L., Rabinovici, G. D., Höglund, K., Ballard, C., Hortobágyi, T., Blennow, K., Svenningsson, P., Zetterberg, H., & Aarsland, D. (2020). An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders. Nature Reviews Neurology, 16, 265-284. https://doi.org/10.1038/s41582-020-0348-0

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for... Read More about An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Systematic review of gene expression studies in people with Lewy body dementia (2020)
Journal Article
Chowdhury, A., & Rajkumar, A. P. (2020). Systematic review of gene expression studies in people with Lewy body dementia. Acta Neuropsychiatrica, 32(6), 281-292. https://doi.org/10.1017/neu.2020.13

Objectives:
Lewy body dementia (LBD) is the second most prevalent neurodegenerative dementia, and it causes more morbidity and mortality than Alzheimer's disease. Several genetic associations of LBD have been reported, and their functional implicati... Read More about Systematic review of gene expression studies in people with Lewy body dementia.

Systematic review of genetic association studies in people with Lewy body dementia (2020)
Journal Article
Sanghvi, H., Singh, R., Morrin, H., & Rajkumar, A. P. (2020). Systematic review of genetic association studies in people with Lewy body dementia. International Journal of Geriatric Psychiatry, 35(5), 436-448. https://doi.org/10.1002/gps.5260

Objectives

Lewy body dementia (LBD) causes more morbidity, disability, and earlier mortality than Alzheimer disease. Molecular mechanisms underlying neurodegeneration in LBD are poorly understood. We aimed to do a systematic review of all genetic... Read More about Systematic review of genetic association studies in people with Lewy body dementia.