Professor JOHN KING's Outputs (8)

Assessing the impact of physicochemical parameters in the predictive capabilities of thermodynamics-based stoichiometric approaches under mesophilic and thermophilic conditions (2020)
Preprint / Working Paper
Tomi-Andrino, C., Norman, R., Millat, T., Soucaille, P., Winzer, K., Barrett, D. A., King, J., & Kim, D.-H. (2020). Assessing the impact of physicochemical parameters in the predictive capabilities of thermodynamics-based stoichiometric approaches under mesophilic and thermophilic conditions. bioRXiv. https://www.biorxiv.org/content/10.1101/2020.02.03.932855v2

Metabolic engineering in the post-genomic era is characterised by the development of new methods for metabolomics and fluxomics, supported by the integration of genetic engineering tools and mathematical modelling. Particularly, constraint-based stoi... Read More about Assessing the impact of physicochemical parameters in the predictive capabilities of thermodynamics-based stoichiometric approaches under mesophilic and thermophilic conditions.

Type II singularities on complete non-compact Yamabe flow (2020)
Journal Article
Choi, B., Daskalopoulos, P., & King, J. (2021). Type II singularities on complete non-compact Yamabe flow. Journal für die reine und angewandte Mathematik, 2021(772), 83-119. https://doi.org/10.1515/crelle-2020-0032

This work concerns with the existence and detailed asymptotic analysis of Type II singularities for solutions to complete non-compact confor-mally flat Yamabe flow with cylindrical behavior at infinity. We provide the specific blow-up rate of the max... Read More about Type II singularities on complete non-compact Yamabe flow.

Type II Singularities on complete non-compact Yamabe flow (2020)
Journal Article
Choi, B., Daskalopoulos, P., & King, J. (2021). Type II Singularities on complete non-compact Yamabe flow. Journal für die reine und angewandte Mathematik, 2021(772), 83-119. https://doi.org/10.1515/crelle-2020-0032

This work concerns with the existence and detailed asymptotic analysis of Type II singularities for solutions to complete non-compact confor-mally flat Yamabe flow with cylindrical behavior at infinity. We provide the specific blow-up rate of the max... Read More about Type II Singularities on complete non-compact Yamabe flow.

Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay (2020)
Journal Article
Dalwadi, M. P., Orol, D., Walter, F., Minton, N. P., King, J. R., & Kovács, K. (2020). Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay. Journal of Mathematical Biology, 81(2), 649-690. https://doi.org/10.1007/s00285-020-01524-8

We investigate how to characterize the kinetic parameters of an aminotransaminase using a non-standard coupled (or auxiliary) enzyme assay, where the peculiarity arises for two reasons. First, one of the products of the auxiliary enzyme is a substrat... Read More about Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay.

A Systematic Upscaling of Nonlinear Chemical Uptake Within a Biofilm (2020)
Journal Article
Dalwadi, M. P., & King, J. R. (2020). A Systematic Upscaling of Nonlinear Chemical Uptake Within a Biofilm. SIAM Journal on Applied Mathematics, 80(4), 1723-1750. https://doi.org/10.1137/19m130220x

When modelling transport of a chemical species to a colony of bacteria in a biofilm, it is computationally expensive 4 to treat each bacterium even as a point sink, let alone to capture the finite nature of each bacterium. Instead, models tend to 5 t... Read More about A Systematic Upscaling of Nonlinear Chemical Uptake Within a Biofilm.

Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions (2020)
Journal Article
Grigoriou, S., Kugler, P., Kulcinskaja, E., Walter, F., King, J., Hill, P., Wendisch, V. F., & O'Reilly, E. (2020). Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions. Green Chemistry, 22(13), 4128-4132. https://doi.org/10.1039/d0gc01432j

The development of biocatalytic routes for the synthesis of chiral amines starting from achiral building blocks is highly desirable. Here, we report a self-sufficient whole-cell system for the conversion of a model ketone to the corresponding cyclic... Read More about Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions.

Mathematical model to determine the effect of a sub-glycocalyx space (2020)
Journal Article
Dalwadi, M. P., Dalwadi, M. P., King, J. R., Dyson, R. J., & Arkill, K. P. (2020). Mathematical model to determine the effect of a sub-glycocalyx space. Physical Review Fluids, 5(4), 043103. https://doi.org/10.1103/physrevfluids.5.043103

We consider the drainage of blood plasma across the capillary wall, focusing on the flow through the endothelial glycocalyx layer that coats the luminal surface of vascular endothelial cells. We investigate how the presence of a sub-glycocalyx space... Read More about Mathematical model to determine the effect of a sub-glycocalyx space.

An asymptotic analysis of the malonyl-CoA route to 3-hydroxypropionic acid in genetically engineered microbes (2020)
Journal Article
Dalwadi, M. P., & King, J. R. (2020). An asymptotic analysis of the malonyl-CoA route to 3-hydroxypropionic acid in genetically engineered microbes. Bulletin of Mathematical Biology, 82, 36. https://doi.org/10.1007/s11538-020-00714-1

There has been recent interest in creating an efficient microbial production route for 3-hydroxypropionic acid, an important platform chemical. We develop and solve a mathematical model for the time-dependent metabolite concentrations in the malonyl-... Read More about An asymptotic analysis of the malonyl-CoA route to 3-hydroxypropionic acid in genetically engineered microbes.