Professor GARY MIRAMS's Outputs (10)

Derivative-based Inference for Cell and Channel Electrophysiology Models (2022)
Presentation / Conference Contribution
Clerx, M., Augustin, D., Dale-Evans, A. R., & Mirams, G. R. (2022, September). Derivative-based Inference for Cell and Channel Electrophysiology Models. Presented at 2022 Computing in Cardiology Conference, Tampere, Finland (online)

Models of ionic currents or of the cardiac action potential (AP) are frequently calibrated by defining an error function that quantifies the mismatch between simulations and data, and using numerical optimisation to find the parameter values that min... Read More about Derivative-based Inference for Cell and Channel Electrophysiology Models.

Normalisation of Action Potential Data Recorded with Sharp Electrodes Maximises Its Utility for Model Development (2022)
Presentation / Conference Contribution
Barral, Y. S. H., Polonchuk, L., R. Mirams, G., Clerx, M., Page, G., Sweat, K., Abi-Gerges, N., Wang, K., & Gavaghan, D. J. (2022, September). Normalisation of Action Potential Data Recorded with Sharp Electrodes Maximises Its Utility for Model Development. Presented at 2022 Computing in Cardiology Conference, Tampere, Finland

In silico models of cardiomyocyte electrophysiology describe the various ionic currents and fluxes that lead to the formation of action potentials (APs). Experimental data used to create such models can be recorded in adult human cardiac trabeculae u... Read More about Normalisation of Action Potential Data Recorded with Sharp Electrodes Maximises Its Utility for Model Development.

Modelling the Effect of Intracellular Calcium in the Rundown of L-Type Calcium Current (2022)
Presentation / Conference Contribution
Agrawal, A., Clerx, M., Wang, K., Polonchuk, L., Gavaghan, D. J., & Mirams, G. R. (2022, September). Modelling the Effect of Intracellular Calcium in the Rundown of L-Type Calcium Current. Presented at 2022 Computing in Cardiology Conference, Tampere, Finland

The L-type calcium current (ICaL) is a key current of the heart playing an important role in the contraction of the cardiomyocyte. Patch-clamp recordings of ionic currents can be associated with a reduction of the current magnitude with time (termed... Read More about Modelling the Effect of Intracellular Calcium in the Rundown of L-Type Calcium Current.

Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment (2020)
Presentation / Conference Contribution
Camporesi, M., Bartolucci, C., Lei, C. L., Mirams, G. R., De Boer, T. P., & Severi, S. (2020, September). Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment. Presented at Computing in Cardiology, Rimini, Italy

© 2020 Creative Commons; the authors hold their copyright. As drugs can be multichannel blockers it is important to assess their cardiac safety taking into account multiple currents. In silico action potential (AP) models have been proposed for being... Read More about Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment.

Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces (2016)
Presentation / Conference Contribution
Johnstone, R. H., Bardenet, R., Gavaghan, D. J., Polonchuk, L., Davies, M. R., & Mirams, G. R. Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces. Presented at 2016 Computing in Cardiology Conference (CinC), Vancouver, BC, Canada

© 2016 CCAL. There are many sources of uncertainty in the recording and modelling of membrane action potentials (APs) from cardiomyocytes. For example, there are measurement, parameter, and model uncertainties. There is also extrinsic variability bet... Read More about Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces.

Novel Voltage Protocols for Determining hERG Channel Kinetics (2015)
Presentation / Conference Contribution
R. Mirams, G., Beattie, K., B. Louttit, J., de Boer, T., & J. Gavaghan, D. (2015, February). Novel Voltage Protocols for Determining hERG Channel Kinetics. Presented at Biophysical Society 59th Annual Meeting, Baltimore, Maryland

Drug interactions with cardiac ion channels can cause disturbances to normal electrical activity in the heart. In particular, hERG channel block has been linked with QT prolongation and increased pro-arrhythmic risk. Consequently, hERG channel screen... Read More about Novel Voltage Protocols for Determining hERG Channel Kinetics.

Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures (2014)
Presentation / Conference Contribution
A.B. Burton, R., Stephens, G., Sharkey, A., Bilton, S., Larsen, H., Kramer, H., Schmidt, C., Molina, C., Li, D., Mirams, G., Robinson, C., Paterson, D., & Bub, G. (2014, February). Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures. Presented at 58th Annual Meeting Biophysical Society, San Francisco

A variety of arrhythmias have been attributed to formation of large scale patterns of excitation such as formation and break-up of spiral waves. We investigate the relationship between neuronal activity and evolution of macroscopic spatiotemporal dyn... Read More about Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures.

Evaluation of computational modelling as a preclinical proarrhythmic safety assay (2013)
Presentation / Conference Contribution
Mirams, G., Beattie, K., Cui, Y., Luscombe, C., Williams, G., Gavaghan, D., & McMahon, N. (2012, October). Evaluation of computational modelling as a preclinical proarrhythmic safety assay. Presented at Safety Pharmacology Society Annual Meeting, Phoenix, AZ

Many cardiac ion channels are prone to reduced current flow following blockade by pharmaceutical compounds. High throughput screening technologies now allow us to establish this reduction in activity routinely and relatively cheaply. It would be adva... Read More about Evaluation of computational modelling as a preclinical proarrhythmic safety assay.

Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings (2013)
Presentation / Conference Contribution
Walmsley, J., Mirams, G. R., Efimov, I. R., Burrage, K., & Rodriguez, B. (2013, June). Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings. Presented at 7th International Conference, FIMH 2013, London, UK

Experimental recordings of transmural activation in the human left ventricle show variability in recorded activation times. In this paper we demonstrate a framework for fitting the conductivity tensor of a monodomain model to reproduce activation tim... Read More about Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings.

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes (2010)
Presentation / Conference Contribution
Walmsley, J., Mirams, G., Bahoshy, M., Bollensdorff, C., Rodriguez, B., & Burrage, K. (2010, August). Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. Presented at 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina

Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beatto- beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells... Read More about Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes.