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Mrs POOJITHA RAJASEKAR's Outputs (5)

Interplay between genetics and epigenetics in lung fibrosis (2025)
Journal Article
Valand, A., Rajasekar, P., Wain, L. V., & Clifford, R. L. (2025). Interplay between genetics and epigenetics in lung fibrosis. International Journal of Biochemistry and Cell Biology, 180, Article 106739. https://doi.org/10.1016/j.biocel.2025.106739

Lung fibrosis, including idiopathic pulmonary fibrosis (IPF), is a complex and devastating disease characterised by the progressive scarring of lung tissue leading to compromised respiratory function. Aberrantly activated fibroblasts deposit extracel... Read More about Interplay between genetics and epigenetics in lung fibrosis.

Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation (2023)
Journal Article
Rajasekar, P., Hall, R. J., Binaya, K., Mahapatra, P. S., Puppala, S. P., Thakker, D., MacIsaac, J. L., Lin, D., Kobor, M., Bolton, C. E., Sayers, I., Hall, I. P., & Clifford, R. L. (2023). Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation. Environmental Pollution, 337, Article 122561. https://doi.org/10.1016/j.envpol.2023.122561

Household air pollution caused by inefficient cooking practices causes 4 million deaths a year worldwide. In Nepal, 86% of the rural population use solid fuels for cooking. Over 25% of premature deaths associated with air pollution are respiratory in... Read More about Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation.

Use of novel DNA methylation signatures to distinguish between human airway structural cell types (2017)
Presentation / Conference Contribution
Rajasekar, P., Clifford, R., MacIsaac, J., McEwen, L., Kobor, M., & Knox, A. Use of novel DNA methylation signatures to distinguish between human airway structural cell types. Presented at American Thoracic Society 2017 International Conference

INTRODUCTION: Chronic inflammatory and fibrotic lung diseases like asthma, COPD and pulmonary fibrosis are characterised by modified phenotype of the airway structural cells. Airway walls are comprised of a robust epithelial layer that lines the lume... Read More about Use of novel DNA methylation signatures to distinguish between human airway structural cell types.

Investigating genome wide DNA methylation in bronchial and lung fibroblasts from healthy individuals and individuals with COPD (2017)
Presentation / Conference Contribution
Clifford, R., Fishbane, N., Rajasekar, P., MacIsaac, J., McEwen, L., Fisher, A., Kobor, M., Knox, A., & Hackett, T.-L. Investigating genome wide DNA methylation in bronchial and lung fibroblasts from healthy individuals and individuals with COPD. Presented at American Thoracic Society 2017 International Conference

Rationale: Lung fibroblasts are implicated in respiratory disease pathology including chronic obstructive pulmonary disease (COPD). Phenotypic differences between fibroblasts isolated from the bronchi versus the lung parenchyma have been described bu... Read More about Investigating genome wide DNA methylation in bronchial and lung fibroblasts from healthy individuals and individuals with COPD.