TANIA DOTTORINI's Outputs (20)

Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity (2024)
Journal Article
Maciel-Guerra, A., Babaarslan, K., Baker, M., Rahman, A., Hossain, M., Sadique, A., Alam, J., Uzzaman, S., Ferdous, M., Ferdous Rahman Sarker, M., Sultana, N., Islam Khan, A. I., Begum, Y. A., Afrad, M. H., Senin, N., Habib, Z. H., Shirin, T., Qadri, F., & Dottorini, T. (2024). Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity. Nature Communications, 15(1), Article 8231. https://doi.org/10.1038/s41467-024-52238-0

In Bangladesh, Vibrio cholerae lineages are undergoing genomic evolution, with increased virulence and spreading ability. However, our understanding of the genomic determinants influencing lineage transmission and disease severity remains incomplete.... Read More about Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity.

Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics (2023)
Journal Article
Chio, H., Guest, E. E., Hobman, J. L., Dottorini, T., Hirst, J. D., & Stekel, D. J. (2023). Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics. Journal of Molecular Graphics and Modelling, 123, Article 108508. https://doi.org/10.1016/j.jmgm.2023.108508

Antibiotics enter the environment through waste streams, where they can exert selective pressure for antimicrobial resistance in bacteria. However, many antibiotics are excreted as partly metabolized forms, or can be subject to partial breakdown in w... Read More about Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics.

Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock (2022)
Journal Article
Maciel-Guerra, A., Baker, M., Hu, Y., Wang, W., Zhang, X., Rong, J., Zhang, Y., Zhang, J., Kaler, J., Renney, D., Loose, M., Emes, R. D., Liu, L., Chen, J., Peng, Z., Li, F., & Dottorini, T. (2023). Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock. ISME Journal, 17(1), 21-35. https://doi.org/10.1038/s41396-022-01315-7

A debate is currently ongoing as to whether intensive livestock farms may constitute reservoirs of clinically relevant antimicrobial resistance (AMR), thus posing a threat to surrounding communities. Here, combining shotgun metagenome sequencing, mac... Read More about Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock.

Identifying associations between management practices and antimicrobial resistances of sentinel bacteria recovered from bulk tank milk on dairy farms (2022)
Journal Article
McLaughlin, D., Bradley, A., Dottorini, T., Giebel, K., Leach, K., Hyde, R., & Green, M. (2022). Identifying associations between management practices and antimicrobial resistances of sentinel bacteria recovered from bulk tank milk on dairy farms. Preventive Veterinary Medicine, 204, Article 105666. https://doi.org/10.1016/j.prevetmed.2022.105666

There is increasing emphasis on the need to reduce antimicrobial use (AMU) on dairy farms to reduce the emergence of resistant bacteria which could compromise animal health and impact human medicine. In addition to AMU, the role of farm management is... Read More about Identifying associations between management practices and antimicrobial resistances of sentinel bacteria recovered from bulk tank milk on dairy farms.

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster (2021)
Journal Article
Peng, Z., Dottorini, T., Hu, Y., Li, M., Yan, S., Fanning, S., …Li, F. (2021). Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster. Frontiers in Microbiology, 12, Article 628538. https://doi.org/10.3389/fmicb.2021.628538

The environmental bacterium Burkholderia gladioli pv. cocovenenans (B. cocovenenans) has been linked to fatal food poisoning cases in Asia and Africa. Bongkrekic acid (BA), a mitochondrial toxin produced by B. cocovenenans, is thought to be responsib... Read More about Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster.

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control (2021)
Journal Article
O’Loughlin, S. M., Forster, A. J., Fuchs, S., Dottorini, T., Nolan, T., Crisanti, A., & Burt, A. (2021). Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control. G3, 11(6), Article jkab086. https://doi.org/10.1093/g3journal/jkab086

DNA sequences that are exactly conserved over long evolutionary time scales have been observed in a variety of taxa. Such sequences are likely under strong functional constraint and they have been useful in the field of comparative genomics for ident... Read More about Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control.

Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication (2020)
Journal Article
Goulding, L. V., Yang, J., Jiang, Z., Zhang, H., Lea, D., Emes, R. D., …Chang, K. C. (2020). Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication. Viruses, 12(10), Article 1093. https://doi.org/10.3390/v12101093

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Influenza A... Read More about Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication.

Epidemiological study on prevalence, serovar diversity, multi-drug resistance and CTX-M-type extended-spectrum β-lactamases of Salmonella spp. from patients with diarrhea, food of animal origin, and pets in several provinces of China (2020)
Journal Article
Wang, W., Zhao, L., Hu, Y., Dottorini, T., Fanning, S., Xu, J., & Li, F. (2020). Epidemiological study on prevalence, serovar diversity, multi-drug resistance and CTX-M-type extended-spectrum β-lactamases of Salmonella spp. from patients with diarrhea, food of animal origin, and pets in several provinces of China. Antimicrobial Agents and Chemotherapy, 64(7), Article e00092-20. https://doi.org/10.1128/aac.00092-20

A total of 2,283 Salmonella isolates were recovered from 18,334 samples, including samples from patients with diarrhea, food of animal origin, and pets, across 5 provinces of China. The highest prevalence of Salmonella spp. was detected in chicken me... Read More about Epidemiological study on prevalence, serovar diversity, multi-drug resistance and CTX-M-type extended-spectrum β-lactamases of Salmonella spp. from patients with diarrhea, food of animal origin, and pets in several provinces of China.

Transcriptional plasticity buffers genetic variation in zinc homeostasis (2019)
Journal Article
Pita-Barbosa, A., Ricachenevsky, F. K., Wilson, M., Dottorini, T., & Salt, D. E. (2019). Transcriptional plasticity buffers genetic variation in zinc homeostasis. Scientific Reports, 9, Article 19482. https://doi.org/10.1038/s41598-019-55736-0

In roots of Arabidopsis thaliana, Zn can be either loaded into the xylem for translocation to the shoot or stored in vacuoles. Vacuolar storage is achieved through the action of the Zn/Cd transporter HMA3 (Heavy Metal Atpase 3). The Col-0 accession h... Read More about Transcriptional plasticity buffers genetic variation in zinc homeostasis.

Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature (2019)
Journal Article
Vázquez-Diosdado, J., Miguel-Pacheco, G., Plant, B., Dottorini, T., Green, M., & Kaler, J. (2019). Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature. Journal of Dairy Science, 102(11), 10471-10482. https://doi.org/10.3168/jds.2019-16442

© 2019 American Dairy Science Association In this study, we assessed for the first time the use of a reticuloruminal temperature bolus and a thresholding method to detect drinking events and investigated different factors that can affect drinking beh... Read More about Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature.

Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis (2018)
Journal Article
Probert, C., Dottorini, T., Speakman, A., Hunt, S., Nafee, T., Fazeli, A., …James, V. (2019). Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis. Oncogene, 38(10), 1751-1763. https://doi.org/10.1038/s41388-018-0540-5

© 2018, The Author(s). The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to ge... Read More about Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis.

Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures (2018)
Journal Article
Cong, W., Dottorini, T., Khan, F., Emes, R. D., Zhang, F.-K., Zhou, C.-X., …Zhu, X.-Q. (2018). Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures. Frontiers in Immunology, 9, Article 2403. https://doi.org/10.3389/fimmu.2018.02403

RNA-sequencing was used to detect transcriptional changes in six tissues of cats, seven days after T. gondii infection. A total of 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver e... Read More about Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures.

A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells (2018)
Journal Article
Tian, A.-L., Lu, M., Calderón-Mantilla, G., Petsalaki, E., Dottorini, T., Tian, X., Wang, Y., Huang, S.-Y., Hou, J.-L., Li, X., Elsheikha, H. M., & Zhu, X.-Q. (2018). A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells. Parasites and Vectors, 11(1), https://doi.org/10.1186/s13071-018-2745-4

Background

The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We... Read More about A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells.

Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes (2016)
Journal Article
Brantley Hall, A., Dottorini, T., Papathanos, P.-A., Sharma, A., Cheng, C., Akbari, O. S., Assour, L., Bergman, N. H., Cagnetti, A., Crisanti, A., Fiorentini, E., Galizi, R., Hnath, J., Jiang, X., Koren, S., Nolan, T., Radune, D., Sharakhova, M. V., Steele, A., Timoshevskiy, V. A., …Besansky, N. J. (2016). Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proceedings of the National Academy of Sciences, 113(15), E2114-E2123. https://doi.org/10.1073/pnas.1525164113

VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria (2015)
Journal Article
Canavese, M., Dottorini, T., & Crisanti, A. (2015). VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria. Pathogens and Global Health, 109(6), https://doi.org/10.1179/2047773215Y.0000000018

Malaria infection induces, alongside endothelial damage and obstruction hypoxia, a potent inflammatory response similar to that observed in other systemic diseases caused by bacteria and viruses. Accordingly, it is increasingly recognised that cerebr... Read More about VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria.

Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes (2015)
Journal Article
Neafsey, D. E., Waterhouse, R. M., Abai, M. R., Aganezov, S. S., Alekseyev, M. A., Allen, J. E., Amon, J., Arcà, B., Arensburger, P., Artemov, G., Assour, L. A., Basseri, H., Berlin, A., Birren, B. W., Blandin, S. A., Brockman, A. I., Burkot, T. R., Burt, A., Chan, C. S., Chauve, C., …Besansky, N. J. (2015). Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. 00 Journal not listed, 347(6217), Article 1258522. https://doi.org/10.1126/science.1258522

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vecto... Read More about Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data (2013)
Journal Article
Dottorini, T., Palladino, P., Senin, N., Persampieri, T., Spaccapelo, R., & Crisanti, A. (2013). CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data. PLoS ONE, 8(6), Article e66196. https://doi.org/10.1371/journal.pone.0066196

The full understanding of the mechanisms underlying transcriptional regulatory networks requires unravelling of complex causal relationships. Genome high-throughput technologies produce a huge amount of information pertaining gene expression and regu... Read More about CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data.

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female (2012)
Journal Article
Dottorini, T., Persampieri, T., Palladino, P., Baker, D. A., Spaccapelo, R., Senin, N., & Crisanti, A. (2013). Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female. FASEB Journal, 27(1), 86-97. https://doi.org/10.1096/fj.12-219444

In Drosophila, the accessory gland proteins (Acps) secreted from the male accessory glands (MAGs) and transferred along with sperm into the female reproductive tract have been implicated in triggering postmating behavioral changes, including refracto... Read More about Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.