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Dr MATTHIAS BROCK's Outputs (31)

A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore (2017)
Journal Article
Brandenburger, E., Gressler, M., Leonhardt, R., Lackner, G., Habel, A., Hertweck, C., Brock, M., & Hoffmeister, D. (in press). A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Applied and Environmental Microbiology, https://doi.org/10.1128/AEM.01478-17

The model white-rot basidiomycete Ceriporiopsis (Gelatoporia) subvermispora B encodes putative natural product biosynthesis genes. Among them is the gene for the seven-domain nonribosomal peptide synthetase CsNPS2. It is a member of the as-yet unchar... Read More about A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore.

Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs (2017)
Journal Article
Hsieh, S.-H., & Brock, M. (in press). Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs. Fungal Biology, https://doi.org/10.1016/j.funbio.2017.08.002

Fungi and bacteria can persist in the human gall bladder. Previous studies have shown that bile protects Candida albicans in this cryptic host niche from antifungals, providing a reservoir for intestinal re-colonization after discontinuation of antif... Read More about Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs.

Encapsulation of antifungals in micelles protects Candida albicans during gall-bladder infection (2017)
Journal Article
Hsieh, S.-H., Brunke, S., & Brock, M. (2017). Encapsulation of antifungals in micelles protects Candida albicans during gall-bladder infection. Frontiers in Microbiology, 8, Article 117. https://doi.org/10.3389/fmicb.2017.00117

Candida albicans is a dimorphic fungus that colonizes human mucosal surfaces with the potential to cause life-threatening invasive candidiasis. Studies on systemic candidiasis in a murine infection model using in vivo real-time bioluminescence imagin... Read More about Encapsulation of antifungals in micelles protects Candida albicans during gall-bladder infection.

Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes (2016)
Journal Article
Naranjo-Ortíz, M. A., Brock, M., Brunke, S., Hube, B., Marcet-Houben, M., & Gabaldón, T. (2016). Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.02001

Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions may be more prone to HGT th... Read More about Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes.

Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens (2016)
Journal Article
Kalleda, N., Amich, J., Arslan, B., Poreddy, S., Mattenheimer, K., Mokhtari, Z., Einsele, H., Brock, M., Heinze, K. G., & Beilhack, A. (2016). Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.01107

Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. In contrast, A. fumigatus causes devastating infec... Read More about Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens.

A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress (2016)
Journal Article
Geib, E., Gressler, M., Viediernikova, I., Hillmann, F., Jacobsen, I. D., Nietzsche, S., Hertweck, C., & Brock, M. (2016). A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress. Cell Chemical Biology, 23(5), https://doi.org/10.1016/j.chembiol.2016.03.014

Pro- and eukaryotes produce melanin for protection from environmental stress or as virulence determinant. The human pathogenic fungus Aspergillus fumigatus and related Ascomycetes produce dihydroxynaphthalene (DHN) melanin in conidia, which is essent... Read More about A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress.

Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge (2016)
Journal Article
Savers, A., Rasid, O., Parlato, M., Brock, M., Jouvion, G., Ryffel, B., Cavaillon, J.-M., Eberl, G., & Ibrahim-Granet, O. (2016). Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge. PLoS ONE, 11(4), Article e0153829. https://doi.org/10.1371/journal.pone.0153829

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge... Read More about Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge.

Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals (2015)
Journal Article
Gressler, M., Meyer, F., Heine, D., Hortschansky, P., Hertweck, C., & Brock, M. (2015). Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. eLife, 4, Article e07861. https://doi.org/10.7554/eLife.07861.001

Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators,... Read More about Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals.

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster (2015)
Journal Article
Gressler, M., Hortschansky, P., Geib, E., & Brock, M. (2015). A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster. Frontiers in Microbiology, 6, https://doi.org/10.3389/fmicb.2015.00184

Recently, the Aspergillus terreus terrein gene cluster was identified and selected for development of a new heterologous expression system. The cluster encodes the specific transcription factor TerR that is indispensable for terrein cluster induction... Read More about A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.

Terrein Biosynthesis in Aspergillus terreus and Its Impact on Phytotoxicity (2014)
Journal Article
Zaehle, C., Gressler, M., Shelest, E., Geib, E., Hertweck, C., & Brock, M. (2014). Terrein Biosynthesis in Aspergillus terreus and Its Impact on Phytotoxicity. Cell Chemistry Biology, 21(6), 719-731. https://doi.org/10.1016/j.chembiol.2014.03.010

Terrein is a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities. Although it is produced by Aspergillus terreus as one of its major secondary metabolites, not much is known about its biosynthetic pathway... Read More about Terrein Biosynthesis in Aspergillus terreus and Its Impact on Phytotoxicity.