Catalytic reductive N-alkylation of amines using carboxylic acids
(2015)
Journal Article
Andrews, K. G., Summers, D., Donnelly, L., & Denton, R. M. (2015). Catalytic reductive N-alkylation of amines using carboxylic acids. Chemical Communications, https://doi.org/10.1039/C5CC08881J
We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.