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Simon Welham's Outputs (32)

Vegans and vegetarians living in Nottingham (UK) continue to be at risk of iodine deficiency (2022)
Journal Article
Eveleigh, E., Coneyworth, L., Zhou, M., Burdett, H., Malla, J., Nguyen, V. H., & Welham, S. (2023). Vegans and vegetarians living in Nottingham (UK) continue to be at risk of iodine deficiency. British Journal of Nutrition, 129(9), 1510-1527. https://doi.org/10.1017/S0007114522000113

Iodine is essential for thyroid hormone synthesis. Individuals adhering to vegan and vegetarian diets have been found to be vulnerable to iodine deficiency. Yet, iodine has not been monitored in these groups across time. This study aims to investigat... Read More about Vegans and vegetarians living in Nottingham (UK) continue to be at risk of iodine deficiency.

Vegans, Vegetarians, and Omnivores: How Does Dietary Choice Influence Iodine Intake? A Systematic Review (2020)
Journal Article
Eveleigh, E. R., Coneyworth, L. J., Avery, A., & Welham, S. J. (2020). Vegans, Vegetarians, and Omnivores: How Does Dietary Choice Influence Iodine Intake? A Systematic Review. Nutrients, 12(6), Article 1606. https://doi.org/10.3390/nu12061606

Vegan and vegetarian diets are becoming increasingly popular. Dietary restrictions may increase the risk of iodine deficiency. This systematic review aims to assess iodine intake and status in adults following a vegan or vegetarian diet in industrial... Read More about Vegans, Vegetarians, and Omnivores: How Does Dietary Choice Influence Iodine Intake? A Systematic Review.

Trace Mineral Intake and Deficiencies in Older Adults Living in the Community and Institutions: A Systematic Review (2020)
Journal Article
Vural, Z., Avery, A., Kalogiros, D. I., Coneyworth, L. J., & Welham, S. J. (2020). Trace Mineral Intake and Deficiencies in Older Adults Living in the Community and Institutions: A Systematic Review. Nutrients, 12(4), Article 1022. https://doi.org/10.3390/nu12041072

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The global population is ageing with many older adults suffering from age-related malnutrition, including micronutrient deficiencies. Adequate nutrient intake is vital to enable older adults t... Read More about Trace Mineral Intake and Deficiencies in Older Adults Living in the Community and Institutions: A Systematic Review.

Geographical and seasonal variation in Iodine content of cow’s milk in the UK and consequences for the consumer´s supply (2020)
Journal Article
Coneyworth, L. J., Welham, S. J., Coulthard, L. C., Bailey, E. H., Young, S. D., Stubberfield, J., Parsons, L., Saunders, N., Watson, E., & Homer, E. M. (2020). Geographical and seasonal variation in Iodine content of cow’s milk in the UK and consequences for the consumer´s supply. Journal of Trace Elements in Medicine and Biology, 59, Article 126453. https://doi.org/10.1016/j.jtemb.2020.126453

Background. Dairy products provide a crucial source of dietary iodine for the majority of the UK population, contributing approximately 30-40 % of daily intake. Fluctuations in the iodine content of purchased milk both seasonally and annually implies... Read More about Geographical and seasonal variation in Iodine content of cow’s milk in the UK and consequences for the consumer´s supply.

LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development (2017)
Journal Article
Sparrow, A. J., Sweetman, D., & Welham, S. J. (2017). LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development. Life Sciences, 186, 17-24. https://doi.org/10.1016/j.lfs.2017.07.034

Aims

Maternal dietary restriction during pregnancy impairs nephron development and results in offspring with fewer nephrons. Cell turnover in the early developing kidney is altered by exposure to maternal dietary restriction and may be regulated b... Read More about LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development.

Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism (2017)
Journal Article
Welham, S. J., Sparrow, A. J., Gardner, D. S., & Elmes, M. J. (2017). Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism. World Journal of Nephrology, 6(1), https://doi.org/10.5527/WJN.v6.i1.21

AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development.
METHODS: Pairs of fetal mouse kidneys at embryonic day 12.5 were cultured... Read More about Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism.

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Devonald, M. A., O’Sullivan, S. E., Gardner, D. S., De Brot, S., Dunford, L. J., Grau-Roma, L., Welham, S. J., Fallman, R., O'Sullivan, S., Oh, W., & Devonald, M. A. J. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310(4), F259-F271. https://doi.org/10.1152/ajprenal.00389.2015

© 2016 the American Physiological Society. Acute kidney injury (AKI) is a common and serious condition with no specific treatment. An episode of AKI may affect organs distant from the kidney, further increasing the morbidity associated with AKI. The... Read More about Remote effects of acute kidney injury in a porcine model.

Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism? (2014)
Journal Article
Gardner, D. S., Welham, S. J., Dunford, L. J., McCulloch, T. A., Hodi, Z., Sleeman, P., O'Sullivan, S., & Devonald, M. A. (2014). Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?. AJP - Renal Physiology, 306(8), F873-F884. https://doi.org/10.1152/ajprenal.00576.2013

Acute kidney injury is common, serious with no specific treatment. Ischemia-reperfusion is a common cause of acute kidney injury (AKI). Clinical trials suggest that preoperative erythropoietin (EPO) or remote ischemic preconditioning may have a renop... Read More about Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?.

Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling (2013)
Journal Article
Gray, C., Al-Dujaili, E. A., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J., & Gardner, D. S. (2013). Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling. PLoS ONE, 8(8), Article e72682. https://doi.org/10.1371/journal.pone.0072682

Hypertension is common and contributes, via cardiovascular disease, towards a large proportion of adult deaths in the Western World. High salt intake leads to high blood pressure, even when occurring prior to birth – a mechanism purported to reside i... Read More about Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling.

Peptic digestion of beef myofibrils is modified by prior marination (2013)
Journal Article
Patel, N., & Welham, S. J. (2013). Peptic digestion of beef myofibrils is modified by prior marination. Food and Nutrition Research, 57(20294), https://doi.org/10.3402/fnr.v57i0.20294

Background: Preparatory steps such as seasoning, marination, and cooking may induce changes in meat
which affects the ability of the stomach to adequately digest it. This may result in peptide chains reaching the
colon intact where resident bacteri... Read More about Peptic digestion of beef myofibrils is modified by prior marination.

Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: Role of fetal exposure to β-hydroxybutyrate (2010)
Journal Article
Langley-Evans, S. C., Daniel, Z. C., Wells, C. A., Ryan, K. J., Plant, R., & Welham, S. J. (2011). Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: Role of fetal exposure to β-hydroxybutyrate. Experimental Physiology, 96(2), 203-215. https://doi.org/10.1113/expphysiol.2010.054460

Maternal undernutrition during sensitive periods of pregnancy results in offspring predisposed towards the development of a number of diseases of adulthood, including hypertension and diabetes. In order to determine the nature of any gross alteration... Read More about Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: Role of fetal exposure to β-hydroxybutyrate.