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Simon Welham's Outputs (28)

LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development (2017)
Journal Article
Sparrow, A. J., Sweetman, D., & Welham, S. J. (2017). LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development. Life Sciences, 186, 17-24. https://doi.org/10.1016/j.lfs.2017.07.034

Aims

Maternal dietary restriction during pregnancy impairs nephron development and results in offspring with fewer nephrons. Cell turnover in the early developing kidney is altered by exposure to maternal dietary restriction and may be regulated b... Read More about LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development.

Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism (2017)
Journal Article
Welham, S. J., Sparrow, A. J., Gardner, D. S., & Elmes, M. J. (2017). Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism. World Journal of Nephrology, 6(1), https://doi.org/10.5527/WJN.v6.i1.21

AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development.
METHODS: Pairs of fetal mouse kidneys at embryonic day 12.5 were cultured... Read More about Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism.

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Devonald, M. A., O’Sullivan, S. E., Gardner, D. S., De Brot, S., Dunford, L. J., Grau-Roma, L., Welham, S. J., Fallman, R., O'Sullivan, S., Oh, W., & Devonald, M. A. J. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310(4), F259-F271. https://doi.org/10.1152/ajprenal.00389.2015

© 2016 the American Physiological Society. Acute kidney injury (AKI) is a common and serious condition with no specific treatment. An episode of AKI may affect organs distant from the kidney, further increasing the morbidity associated with AKI. The... Read More about Remote effects of acute kidney injury in a porcine model.

Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism? (2014)
Journal Article
Gardner, D. S., Welham, S. J., Dunford, L. J., McCulloch, T. A., Hodi, Z., Sleeman, P., O'Sullivan, S., & Devonald, M. A. (2014). Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?. AJP - Renal Physiology, 306(8), F873-F884. https://doi.org/10.1152/ajprenal.00576.2013

Acute kidney injury is common, serious with no specific treatment. Ischemia-reperfusion is a common cause of acute kidney injury (AKI). Clinical trials suggest that preoperative erythropoietin (EPO) or remote ischemic preconditioning may have a renop... Read More about Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?.

Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling (2013)
Journal Article
Gray, C., Al-Dujaili, E. A., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J., & Gardner, D. S. (2013). Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling. PLoS ONE, 8(8), Article e72682. https://doi.org/10.1371/journal.pone.0072682

Hypertension is common and contributes, via cardiovascular disease, towards a large proportion of adult deaths in the Western World. High salt intake leads to high blood pressure, even when occurring prior to birth – a mechanism purported to reside i... Read More about Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling.

Peptic digestion of beef myofibrils is modified by prior marination (2013)
Journal Article
Patel, N., & Welham, S. J. (2013). Peptic digestion of beef myofibrils is modified by prior marination. Food and Nutrition Research, 57(20294), https://doi.org/10.3402/fnr.v57i0.20294

Background: Preparatory steps such as seasoning, marination, and cooking may induce changes in meat
which affects the ability of the stomach to adequately digest it. This may result in peptide chains reaching the
colon intact where resident bacteri... Read More about Peptic digestion of beef myofibrils is modified by prior marination.

Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: Role of fetal exposure to β-hydroxybutyrate (2010)
Journal Article
Langley-Evans, S. C., Daniel, Z. C., Wells, C. A., Ryan, K. J., Plant, R., & Welham, S. J. (2011). Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: Role of fetal exposure to β-hydroxybutyrate. Experimental Physiology, 96(2), 203-215. https://doi.org/10.1113/expphysiol.2010.054460

Maternal undernutrition during sensitive periods of pregnancy results in offspring predisposed towards the development of a number of diseases of adulthood, including hypertension and diabetes. In order to determine the nature of any gross alteration... Read More about Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: Role of fetal exposure to β-hydroxybutyrate.