Using many different voltage protocols to characterise discrepancy in mathematical ion channel models
(2023)
Journal Article
Shuttleworth, J. G., Lok Lei, C., Windley, M., Hill, A. P., Perry, M. D., Preston, S., & Mirams, G. R. (2023). Using many different voltage protocols to characterise discrepancy in mathematical ion channel models. Biophysical Journal, 122(3, Suppl. 1), 242a. https://doi.org/10.1016/j.bpj.2022.11.1415
The Kv11.1 protein encoded by the hERG gene forms the primary subunit of a voltage-sensitive ion channel responsible for IKr in cardiomyocytes. Mathematical models of the macroscopic current are fitted to data from patch-clamp experiments - in which... Read More about Using many different voltage protocols to characterise discrepancy in mathematical ion channel models.