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Dr TANYA MONAGHAN's Outputs (49)

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., Yang, D. Y., Wang, C., Wong, K., Saxinger, L., Pučić-Baković, M., Vučković, F., Klicek, F., Lauc, G., Tighe, P., Mullish, B. H., Blanco, J. M., McDonald, J. A., Marchesi, J. R., Xue, N., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle (2021)
Journal Article
Chidambaram, S. B., Essa, M. M., Rathipriya, A., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A., Sakharkar, M. K., Kashyap, R. S., Friedland, R., & Monaghan, T. M. (2022). Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle. Pharmacology and Therapeutics, 231, Article 107988. https://doi.org/10.1016/j.pharmthera.2021.107988

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut micr... Read More about Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., Blanco, J. M., McDonald, J. A. K., Marchesi, J. R., Yau, T. O., Christodoulou, N., Hatziapostolou, M., Pucic-Bakovic, M., Vuckovic, F., Klicek, F., Lauc, G., Xue, N., Dottorini, T., Ambalkar, S., Satav, A., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs (2021)
Journal Article
Monaghan, T. M., Seekatz, A. M., Markham, N. O., On Yau, T., Hatziapostolou, M., Jilani, T., Christodoulou, N., Roach, B., Birli, E., Pomenya, O., Louie, T., Borden Lacy, D., Kim, P., Lee, C., Kao, D., & Polytarchou, C. (2021). Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs. Gastroenterology, 161(1), 255-270.e4. https://doi.org/10.1053/j.gastro.2021.03.050

Background and aims
The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alter... Read More about Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs.

Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection (2020)
Journal Article
Huus, K. E., Frankowski, M., Pučić-Baković, M., Vučković, F., Lauc, G., Mullish, B. H., Marchesi, J. R., Monaghan, T. M., Kao, D., & Finlay, B. B. (2021). Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection. Gut Microbes, 13(1), 1-12. https://doi.org/10.1080/19490976.2020.1862027

Secretory immunoglobulin A (IgA) interacts with intestinal microbiota and promotes mucosal homeostasis. IgA-bacteria interactions are altered during inflammatory diseases, but how these interactions are shaped by bacterial, host, and environmental fa... Read More about Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection.

Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites (2020)
Journal Article
Martinez-Gili, L., McDonald, J. A., Liu, Z., Kao, D., Allegretti, J. R., Monaghan, T. M., Barker, G. F., Miguéns Blanco, J., Williams, H. R., Holmes, E., Thursz, M. R., Marchesi, J. R., & Mullish, B. H. (2020). Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites. Gut Microbes, 12(1), Article 1810531. https://doi.org/10.1136/gutjnl-2018-317842

Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at present, its mechanisms of efficacy have remained poorly understo... Read More about Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites.

Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., Biswas, R., Nashine, R., Manke, S., Gandhi, J., Jain, P., Bhotmange, S., Ambalkar, S., Satav, A., Draper, L. A., Hill, C., & Singh Kashyap, R. (2020). Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome. Gut Microbes, 12(1), Article 1752605

Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrhoeal diseases, particularly Clostridioides difficile, in rural-agricultural and urban popula... Read More about Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome.

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., Biswas, R., Nashine, R., Manke, S., Gandhi, J., Jain, P., Bhotmange, S., Ambalkar, S., Satav, A., Draper, L. A., Hill, C., & Kashyap, R. S. (2020). Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome. Gut Microbes, 12(1), Article 1752605. https://doi.org/10.1080/19490976.2020.1752605

© 2020, © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal d... Read More about Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

Setting the agenda for social science research on the human microbiome (2020)
Journal Article
Greenhough, B., Read, C. J., Lorimer, J., Lezaun, J., McLeod, C., Benezra, A., Bloomfield, S., Brown, T., Clinch, M., D’Acquisto, F., Dumitriu, A., Evans, J., Fawcett, N., Fortané, N., Hall, L. J., Giraldo Herrera, C. E., Hodgetts, T., Johnson, K. V.-A., Kirchhelle, C., Krzywoszynska, A., …Wills, J. (2020). Setting the agenda for social science research on the human microbiome. Palgrave Communications, 6(2020), Article 18

The human microbiome is an important emergent area of cross, multi and transdisciplinary study. The complexity of this topic leads to conflicting narratives and regulatory challenges. It raises questions about the benefits of its commercialisation an... Read More about Setting the agenda for social science research on the human microbiome.

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection (2019)
Journal Article
Monaghan, T. M., Pučić-Baković, M., Vučković, F., Lee, C., Kao, D., & Human Glycome Project. (2020). Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection. Gastroenterology, 157(6), 1676-1678.e3. https://doi.org/10.1053/j.gastro.2019.08.034

In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation (2019)
Journal Article
McSweeney, B., Allegretti, J. R., Fischer, M., Xu, H., Goodman, K. J., Monaghan, T., McLeod, C., Mullish, B. H., Petrof, E. O., Phelps, E. L., Chis, R., Edminson, A., Juby, A., Ennis-Davis, R., Roach, B., Wong, K., & Kao, D. (2020). In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation. Gut Microbes, 11(1), 51-62. https://doi.org/10.1080/19490976.2019.1611153

Introduction: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection. Stool donors are essential, but difficult to recruit and retain. We identified factors influencing willingness to donate... Read More about In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation.

Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection (2019)
Journal Article
Braim, S., Śpiewakb, K., Brindell, M., Heeg, D., Alexander, C., & Monaghan, T. (2019). Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection. Journal of Pharmaceutical Sciences, 108(7), 2438-2446. https://doi.org/10.1016/j.xphs.2019.02.025

Some forms of bovine lactoferrin (bLf) are effective in delaying Clostridioides difficile growth and preventing toxin production. However, therapeutic use of bLf may be limited by protein stability issues. The objective of this study was to prepare a... Read More about Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection.

Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway (2018)
Journal Article
Monaghan, T. M., Mullish, B. H., Patterson, J., Wong, G. K., Marchesi, J. R., Xu, H., Tahseen, J., & Kao, D. (2018). Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes, https://doi.org/10.1080/19490976.2018.1506667

The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. F... Read More about Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway.

A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection (2018)
Journal Article
Negm, O. H., Hamed, M. R., & Monaghan, T. M. (2018). A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection. Journal of Visualized Experiments, 2018(136), Article e57399. https://doi.org/10.3791/57399

We provide a detailed overview of a novel high-throughput protein microarray assay for the determination of anti-C. difficile antibody levels in human sera and in separate preparations of polyclonal IVIg. The protocol describes the methodological ste... Read More about A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection.

Novel oral targeted therapies in inflammatory bowel disease (2018)
Journal Article
White, J. R., Philips, F., Monaghan, T. M., Fateen, W., Samuel, S., Ghosh, S., & Moran, G. W. (2018). Novel oral targeted therapies in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 47(12), 1610-1622. https://doi.org/10.1111/apt.14669

Background: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of me... Read More about Novel oral targeted therapies in inflammatory bowel disease.