TANYA MONAGHAN Tanya.Monaghan@nottingham.ac.uk
Clinical Associate Professor in Luminal Gastroenterology
Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway
Monaghan, Tanya M.; Mullish, Benjamin H.; Patterson, Jordan; Wong, Gane K.S.; Marchesi, Julian R.; Xu, Huiping; Tahseen, Jilani; Kao, Dina
Authors
Benjamin H. Mullish
Jordan Patterson
Gane K.S. Wong
Julian R. Marchesi
Huiping Xu
Jilani Tahseen
Dina Kao
Abstract
The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host physiology of these FMT-related changes in gut bile acid metabolism are also not well explored. In this study, we investigated the impact of FMT for rCDI upon signalling through the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) pathway. Herein, we identify that in addition to restoration of gut microbiota and bile acid profiles, FMT for rCDI is accompanied by a significant, sustained increase in circulating levels of FGF19 and reduction in FGF21. These FGF changes were associated with weight gain post-FMT, to a level not exceeding the pre-rCDI baseline. Collectively, these data support the hypothesis that the restoration of gut microbial communities by FMT for rCDI is associated with an upregulated FXR-FGF pathway, and highlight the potential systemic effect of FMT.
Citation
Monaghan, T. M., Mullish, B. H., Patterson, J., Wong, G. K., Marchesi, J. R., Xu, H., …Kao, D. (2018). Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes, https://doi.org/10.1080/19490976.2018.1506667
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 25, 2018 |
Online Publication Date | Sep 5, 2018 |
Publication Date | Sep 5, 2018 |
Deposit Date | Jul 23, 2018 |
Publicly Available Date | Mar 29, 2024 |
Journal | Gut Microbes |
Print ISSN | 1949-0976 |
Electronic ISSN | 1949-0976 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1080/19490976.2018.1506667 |
Keywords | microbiota; fecal microbiota transplantation (FMT); recurrent Clostridium difficile infection (rCDI); bile acid metabolism; fibroblast growth factor (FGF)19 |
Public URL | https://nottingham-repository.worktribe.com/output/947614 |
Additional Information | This is an Accepted Manuscript of an article published by Taylor & Francis in Gut microbes on 05/09/2018, available online: https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1506667 |
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