Dr ULVI BAYRAKTUTAN's Outputs (50)

Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction (2025)
Journal Article
Yılmaz, H., & Bayraktutan, U. (2025). Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction. Current Issues in Molecular Biology, 47(4), Article 232. https://doi.org/10.3390/cimb47040232

Cerebral small vessel disease (cSVD) is a common cause of stroke and dementia. Ageing, hypertension, hyperglycaemia, and smoking make up the biggest risk factors for cSVD. They individually or collectively increase the levels of reactive oxygen speci... Read More about Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction.

Donor Variability Alters the Characteristics of Human Brain Microvascular Endothelial Cells (2025)
Journal Article
Ya, J., & Bayraktutan, U. (in press). Donor Variability Alters the Characteristics of Human Brain Microvascular Endothelial Cells. Current Issues in Molecular Biology, 47(2), Article 73. https://doi.org/10.3390/cimb47020073

Primary brain microvascular endothelial cells (BMECs) are widely used in a large number of in vitro studies each year to better mimic their physiological characteristics in vivo. However, potential changes in primary endothelial cells stemming from d... Read More about Donor Variability Alters the Characteristics of Human Brain Microvascular Endothelial Cells.

Metabolites and Metabolic Functional Changes—Potential Markers for Endothelial Cell Senescence (2024)
Journal Article
Ya, J., Whitby, A., & Bayraktutan, U. (2024). Metabolites and Metabolic Functional Changes—Potential Markers for Endothelial Cell Senescence. Biomolecules, 14(11), Article 1476. https://doi.org/10.3390/biom14111476

Accumulation of senescent endothelial cells (ECs) in vasculature represents a key step in the development of vascular aging and ensuing age-related diseases. Given that removal of senescent ECs may prevent disease and improve health and wellbeing, th... Read More about Metabolites and Metabolic Functional Changes—Potential Markers for Endothelial Cell Senescence.

Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group (2024)
Journal Article
Rakkar, K., Kadir, R. R. A., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2024). Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group. Stem Cell Reviews and Reports, 20, 2336–2344. https://doi.org/10.1007/s12015-024-10777-5

Endothelial progenitor cells (EPCs) are stem cells that can repair injured blood vessels through neovascularisation. This is achieved through secretion of growth factors and endothelial maturation. EPC numbers and function have been studied to determ... Read More about Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer Control Group.

Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence (2024)
Journal Article
Ya, J., & Bayraktutan, U. (2024). Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence. Cells, 13(15), Article 1292. https://doi.org/10.3390/cells13151292

Oxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and the ensuing blood–brain barrier (BBB) dysfunction. Through the exposure of an in vitro model of human BBB, composed of brain microvascula... Read More about Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence.

Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function (2024)
Journal Article
Hashmat, A., Ya, J., Kadir, R., Alwjwaj, M., & Bayraktutan, U. (2024). Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function. Tissue Barriers, 13(1), Article 2350821. https://doi.org/10.1080/21688370.2024.2350821

Breakdown of blood-brain barrier (BBB) represents a key pathology in hyperglycemia-mediated cerebrovascular damage after an ischemic stroke. As changes in the level and nature of vasoactive agents released by endothelial cells (ECs) may contribute to... Read More about Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function.

The Role of Stem Cells as Therapeutics for Ischaemic Stroke (2024)
Journal Article
Ya, J., Pellumbaj, J., Hashmat, A., & Bayraktutan, U. (2024). The Role of Stem Cells as Therapeutics for Ischaemic Stroke. Cells, 13(2), Article 112. https://doi.org/10.3390/cells13020112

Stroke remains one of the leading causes of death and disability worldwide. Current reperfusion treatments for ischaemic stroke are limited due to their narrow therapeutic window in rescuing ischaemic penumbra. Stem cell therapy offers a promising al... Read More about The Role of Stem Cells as Therapeutics for Ischaemic Stroke.

Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
ABDULKADIR, R., RAKKAR, K., OTHMAN, O., SPRIGG, N., BATH, P., & BAYRAKTUTAN, U. (2023). Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Scientific Reports, 13, Article 21843. https://doi.org/10.1038/s41598-023-48907-7

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke (2023)
Journal Article
Kadir, R. R. A., Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke. Scientific Reports, 13(1), Article 21843. https://doi.org/10.1038/s41598-023-48907-7

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke.

Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials (2023)
Journal Article
Krishnan, K., Campos, P. B., Nguyen, T. N., Tan, C. W., Chan, S. L., Appleton, J. P., Law, Z., Hollingworth, M., Kirkman, M. A., England, T. J., Roffe, C., Macleod, M. J., Dawson, J., Bayraktutan, U., Werring, D. J., Sprigg, N., & Bath, P. M. (2023). Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials. Frontiers in Stroke, 2, Article 1256664. https://doi.org/10.3389/fstro.2023.1256664

Acute intracerebral hemorrhage is the most devastating stroke subtype and is associated with significant morbidity and mortality. Poor prognosis is associated with primary brain injury from the presenting hematoma, and despite advances in clinical tr... Read More about Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials.

Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies (2023)
Journal Article
Ya, J., & Bayraktutan, U. (2023). Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies. International Journal of Molecular Sciences, 24(14), Article 11538. https://doi.org/10.3390/ijms241411538

Ageing constitutes the biggest risk factor for poor health and adversely affects the integrity and function of all the cells, tissues, and organs in the human body. Vascular ageing, characterised by vascular stiffness, endothelial dysfunction, increa... Read More about Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies.

TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. Immunobiology, 228(5), Article 152706. https://doi.org/10.1016/j.imbio.2023.152706

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB) integrity through a complex mechanism involving activation of both RhoA/Rho kinase/myosin light chain-2 and neurokinin 1 receptor (NK1R). Using an in vitro model of... Read More about TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.

Substance P reversibly compromises the integrity and function of blood-brain barrier (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). Substance P reversibly compromises the integrity and function of blood-brain barrier. Peptides, 167, Article 171048. https://doi.org/10.1016/j.peptides.2023.171048

Background
Substance P (SP) plays a role in vasodilatation and tissue integrity through its receptor, neurokinin 1 (NK1R). However, its specific effect on blood-brain barrier (BBB) remains unknown.

Methods
The impact of SP on the integrity/funct... Read More about Substance P reversibly compromises the integrity and function of blood-brain barrier.

Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Stem Cell Reviews and Reports, 19(6), 1856-1869. https://doi.org/10.1007/s12015-023-10544-y

Ageing impairs endothelial function and predisposes the person to ischaemic stroke (IS). Endothelial progenitor cells (EPCs) repair endothelial damage and induce post-ischaemic neovascularisation. Given the prevalence of IS in older population, this... Read More about Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study (2022)
Journal Article
Mathur, M., Gran, B., Tanasescu, R., Constantinescu, C. S., Bayraktutan, U., & Bayraktutan, U. (2022). SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study. SVOA Neurology, 3(5), 208-213

Background: Breakdown of the blood-brain barrier (BBB) constitutes a key step in the pathogenesis of multiple sclerosis
(MS).
Aims: To investigate whether sera from MS patients in relapse or in remission may differently affect the BBB function
and... Read More about SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study.

Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms (2022)
Journal Article
Kadir, R. R. A., Alwjwaj, M., Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2022). Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-022-10439-4

Improved understanding of the key mechanisms underlying cerebral ischemic injury is essential for the discovery of efficacious novel therapeutics for stroke. Through detailed analysis of plasma samples obtained from a large number of healthy voluntee... Read More about Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms.

Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics (2022)
Journal Article
Ya, J., Reskiawan, R., Kadir, R. R. A., & Bayraktutan, U. (2023). Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics. Tissue Barriers, 11(3), Article 2103353. https://doi.org/10.1080/21688370.2022.2103353

Accumulation of senescent cells in cerebrovasculature is thought to play an important role in age-related disruption of blood–brain barrier (BBB). Using an in vitro model of human BBB, composed of brain microvascular endothelial cells (BMECs), astroc... Read More about Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics.

Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells (2022)
Journal Article
Kadir, R. R. A., Alwjwaj, M., & Bayraktutan, U. (2022). Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells. Metabolic Brain Disease, https://doi.org/10.1007/s11011-022-01041-1

Outgrowth endothelial cells (OECs) provide an endogenous repair mechanism and thus maintain endothelial barrier integrity. As inhibition of protein kinase C-β (PKC-β) activity has been shown to attenuate endothelial damage in various pathological con... Read More about Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells.

Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence (2022)
Journal Article
Gao, X., Frakich, N., Filippini, P., Edwards, L. J., Vinkemeier, U., Gran, B., Tanasescu, R., Bayraktutan, U., Colombo, S., & Constantinescu, C. S. (2022). Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence. Neuropeptides, 95, Article 102265. https://doi.org/10.1016/j.npep.2022.102265

The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and neurogenic inflammation. Its role in the peripheral nervous system has been well characterised. However, its actions on the blood-brain barrier (BBB) ar... Read More about Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence.

Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells (2022)
Journal Article
Reskiawan A. Kadir, R., Alwjwaj, M., Ahmad Othman, O., Rakkar, K., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2022). Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells. Brain Research, 1787, Article 147925. https://doi.org/10.1016/j.brainres.2022.147925

Ageing is characterised by a progressive loss of vascular endothelial function and integrity. Endothelial progenitor cells (EPCs) play an integral role in endothelial regeneration but are prone to age-dependent changes which may accelerate their sene... Read More about Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells.