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Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis (2024)
Journal Article
Alsafy, M. A. M., El-Gendy, S. A. A., Atkinson, B., Sturrock, C. J., Kamal, B. M., Alibhai, A., …Rutland, C. S. (2024). Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis. Microscopy and Microanalysis, 30(3), 574-593. https://doi.org/10.1093/mam/ozae046

Ossa cordis, bones located within the heart trigones, are often classified as heterotopic or ectopic bones. Despite their high prevalence in cattle and some other bovids, little is known about their structure or development. Scanning electron microsc... Read More about Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis.

Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma (2024)
Journal Article
de Brot, S., Cobb, J., Alibhai, A. A., Jackson-Oxley, J., Haque, M., Patke, R., …Rutland, C. S. (2024). Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma. Cancers, 16(10), Article 1945. https://doi.org/10.3390/cancers16101945

Osteosarcoma (OSA) is the most common type of primary bone malignancy in people and dogs. Our previous molecular comparisons of canine OSA against healthy bone resulted in the identification of differentially expressed protein-expressing genes (forkh... Read More about Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., …James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Changes in Immune Response during Pig Gestation with a Focus on Cytokines (2024)
Journal Article
Velez, C., Williamson, D., Lorena Cánovas, M., Romina Giai, L., Rutland, C., Pérez, W., & Barbeito, C. G. (2024). Changes in Immune Response during Pig Gestation with a Focus on Cytokines. Veterinary Sciences, 11(1), Article 50. https://doi.org/10.3390/vetsci11010050

Pigs have the highest percentage of embryonic death not associated with specific diseases of all livestock species, at 20–45%. During gestation processes, a series of complex alterations can arise, including embryonic migration and elongation, matern... Read More about Changes in Immune Response during Pig Gestation with a Focus on Cytokines.

Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish (2023)
Journal Article
Emeish, W. F. A., Fawaz, M. M., Hussein, N. M., Al-Amgad, Z., Abd-ElHafeez, H. H., Rutland, C. S., & Bakry, K. A. (2023). Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish. Microscopy and Microanalysis, 29(5), 1774-1790. https://doi.org/10.1093/micmic/ozad091

Henneguya species are myxozoans, a suborder of Cnidaria, which can affect the gills and extrarespiratory organs of the African sharptooth catfish, Clarias gariepinus. This research describes natural infection-induced histological alterations caused b... Read More about Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish.

Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry (2023)
Journal Article
Alsafy, M. A., El-Gendy, S. A., Kamal, B. M., Rutland, C. S., Abd-Elhafeez, H. H., Soliman, S., …Nomir, A. G. (2023). Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry. BMC Zoology, 8, Article 12. https://doi.org/10.1186/s40850-023-00173-w

Dromedary camel heart morphology is a crucial research topic with clinical applications. The study aims to understand the dromedary camel anatomy, morphology, and architecture of the ventricular mass. Results: Sagittal and transverse gross sections w... Read More about Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry.

Cardiovascular Stem Cell Applications in Experimental Animal Models (2023)
Book Chapter
Jeyapalan, J. N., Cockcroft, J., Rizvanov, A. A., Haider, K. H., & Rutland, C. S. (2023). Cardiovascular Stem Cell Applications in Experimental Animal Models. In K. H. Haider (Ed.), Cardiovascular Applications of Stem Cells (465-490). Springer Nature Singapore. https://doi.org/10.1007/978-981-99-0722-9_16

Stem cells are increasingly used in various species for differing diseases, most frequently experimentally. In addition, several animals are also used as models for both veterinary and human medicine. Differing stem cell types have been trialed with... Read More about Cardiovascular Stem Cell Applications in Experimental Animal Models.

Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758) (2023)
Journal Article
El-Bakary, N. E., Alsafy, M. A., Rutland, C. S., El-Gendy, S. A., & Kamal, B. M. (2023). Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758). Anatomia, Histologia, Embryologia, 52(6), 821-1033. https://doi.org/10.1111/ahe.12943

Trichiurus lepturus is a carnivorous fish, and most of the previous anatomical research has focused on computed tomography imaging and histology of their teeth and fangs, while the remaining structures of pharyngeal cavity remain unexplored. The pres... Read More about Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758).

Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus) (2023)
Journal Article
Abd-Elhafeez, H. H., Rutland, C. S., & Soliman, S. A. (2023). Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus). Microscopy Research and Technique, 86(9), 1108-1121. https://doi.org/10.1002/jemt.24374

Telocytes (TCs) are present in a broad range of species and regulate processes including homeostasis, tissue regeneration and immunosurveillance. This novel study describes the morphological features of migrating TCs and their role during cartilage d... Read More about Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus).

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?. Histopathology, 83(3), 376-393. https://doi.org/10.1111/his.14939

Background Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.

Topographic anatomy and vascularization of the glandula thyroidea in rats (2023)
Journal Article
Nur, I. H., Pérez, W., & Rutland, C. S. (2023). Topographic anatomy and vascularization of the glandula thyroidea in rats. Anatomia, Histologia, Embryologia, 52(4), 571-582. https://doi.org/10.1111/ahe.12916

Topographical anatomy and detailed measurements of the glandula thyroidea (thyroid gland) and the glandula parathyroidea (parathyroid gland) were determined in rats, with significant differences identified between the sexes. In the rats (N=10 male, 1... Read More about Topographic anatomy and vascularization of the glandula thyroidea in rats.

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2023)
Preprint / Working Paper
Kovac, M., Aliev, R., Berestov, I., Aimaletdinov, A., Rutland, C., Rizvanov, A., & Zakirova, E. Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

The Relationship of Sperm Motility Pattern and Its Ability to Agglutinate with Vaginal Sperm Selection, Uptake in Sperm Storage Tubules and Competitiveness (2023)
Book Chapter
Sayed, M. A. M., Abd Elhafeez, H. H., Rutland, C. S., & El-Sherry, T. M. (2023). The Relationship of Sperm Motility Pattern and Its Ability to Agglutinate with Vaginal Sperm Selection, Uptake in Sperm Storage Tubules and Competitiveness. In G. Téllez-Isaías (Ed.), Poultry Farming - New Perspectives and Applications [Working Title]. Rijeka: InTech. https://doi.org/10.5772/intechopen.110198

To ensure survival, some unique features can be distinguished in birds that help them maintain reproduction. These features include the ability to store sperm for long periods within the utero-vaginal junction, a high sperm concentration per ejaculat... Read More about The Relationship of Sperm Motility Pattern and Its Ability to Agglutinate with Vaginal Sperm Selection, Uptake in Sperm Storage Tubules and Competitiveness.

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode (2023)
Journal Article
Baron, F., Zhang, M., Archer, N., Bellows, E., Knight, H. M., Welham, S., …Bodi, Z. (2023). The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode. RNA, 29(6), 777-789. https://doi.org/10.1261/rna.079615.123

N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g... Read More about The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode.

Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells (2023)
Journal Article
Soliman, S. A., Abd-Elhafeez, H. H., Mohamed, N., Al-Rashdi, B. M., Alghamdi, A. A., Elmansi, A., …Massoud, D. (2023). Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells. Microscopy Research and Technique, 86(5), 600-613. https://doi.org/10.1002/jemt.24298

Varanus niloticus is a lizard residing within the Varanidae family. To date no studies detailing its blood morphology and characteristics have been conducted. This study used histologically stained blood and bone marrow samples to visualize the cells... Read More about Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis (2022)
Journal Article
El‐Gendy, S. A., Alsafy, M. A., Rutland, C. S., Ez Elarab, S. M., Abd‐Elhafeez, H. H., & Kamal, B. M. (2023). Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis. Microscopy Research and Technique, 86(1), 53-62. https://doi.org/10.1002/jemt.24256

The present study describes the morphological characteristics of the camel heart Ossa cordis, and os aorta using computed tomography soft tissue window (CT) alongside 3D render volume reconstructions and light microscopy. The current study techniques... Read More about Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis.

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article
Harris, A. E., Metzler, V. M., Lothion-Roy, J., Varun, D., Woodcock, C. L., Haigh, D. B., …Jeyapalan, J. N. (2022). Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Frontiers in Endocrinology, 13, Article 1006101. https://doi.org/10.3389/fendo.2022.1006101

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer (2022)
Journal Article
Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Metzler, V. M., Persson, J. L., …Mongan, N. P. (2022). The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers, 14(20), Article 5148. https://doi.org/10.3390/cancers14205148

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing... Read More about The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

Anatomy, histology, development and functions of Ossa cordis: A review (2022)
Journal Article
Best, A., Egerbacher, M., Swaine, S., Pérez, W., Alibhai, A., Rutland, P., …Rutland, C. S. (2022). Anatomy, histology, development and functions of Ossa cordis: A review. Anatomia, Histologia, Embryologia, 51(6), 683-695. https://doi.org/10.1111/ahe.12861

This systematic review highlights the similarities and variations in Ossa cordis prevalence, histology and anatomical location between differing veterinary species and in humans. In addition, it also identifies associated factors such as aging and ca... Read More about Anatomy, histology, development and functions of Ossa cordis: A review.

Anatomy, histology, development and functions of Ossa cordis: A review (2022)
Journal Article
Best, A., Egerbacher, M., Swaine, S., Pérez, W., Alibhai, A., Rutland, P., …Rutland, C. S. (2022). Anatomy, histology, development and functions of Ossa cordis: A review. Anatomia, Histologia, Embryologia, 51(6), 683-695. https://doi.org/10.1111/ahe.12861

This systematic review highlights the similarities and variations in Ossa cordis prevalence, histology and anatomical location between differing veterinary species and in humans. In addition, it also identifies associated factors such as aging and ca... Read More about Anatomy, histology, development and functions of Ossa cordis: A review.

Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle (2022)
Book Chapter
Hall, J., Barker, E., Best, A., & Rutland, C. S. (2022). Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle. In C. Rutland, & S. El-Gendy (Eds.), Updates on Veterinary Anatomy and Physiology. InTech. https://doi.org/10.5772/intechopen.106576

Pericarditis in cattle can be classified as traumatic pericarditis (TP), idiopathic haemorrhagic, secondary to neoplasia or septic pericarditis due to haematogenous spread of organisms, such as Colibacilli or Pasturella. In cattle, pericardial diseas... Read More about Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle.

Artificial Microvesicles: New Perspective on Healing Tendon Wounds (2022)
Journal Article
Zakirova, E., Aimaletdinov, A., Mansurova, M., Titova, A., Kurilov, I., Rutland, C. S., …Rizvanov, A. (2022). Artificial Microvesicles: New Perspective on Healing Tendon Wounds. Cells Tissues Organs, 213(1), 24-39. https://doi.org/10.1159/000526845

Tendons have a limited capacity to repair both naturally and following clinical interventions. Damaged tissue often presents with structural and functional differences, adversely affecting animal performance, mobility, health, and welfare. Advances i... Read More about Artificial Microvesicles: New Perspective on Healing Tendon Wounds.

Salivary Gland Adaptation to Dietary Inclusion of Hydrolysable Tannins in Boars (2022)
Journal Article
Mavri, M., Čandek-Potokar, M., Fazarinc, G., Škrlep, M., Rutland, C. S., Potočnik, B., …Kubale, V. (2022). Salivary Gland Adaptation to Dietary Inclusion of Hydrolysable Tannins in Boars. Animals, 12(17), Article 2171. https://doi.org/10.3390/ani12172171

The ingestion of hydrolysable tannins as a potential nutrient to reduce boar odor in entire males results in the significant enlargement of parotid glands (parotidomegaly). The objective of this study was to characterize the effects of different leve... Read More about Salivary Gland Adaptation to Dietary Inclusion of Hydrolysable Tannins in Boars.

Isolation, culturing and 3D bioprinting of equine myoblasts (2022)
Journal Article
Aimaletdinov, A., Abyzova, M., Kurilov, I., Yuferova, A., Rutland, C., Rizvanov, A., & Zakirova, E. (2022). Isolation, culturing and 3D bioprinting of equine myoblasts. Biological Communications, 67(3), 152-159. https://doi.org/10.21638/spbu03.2022.302

Isolating and culturing myoblasts is essential for techniques such as tissue regeneration and in vitro meat production. This research describes a protocol to isolate primary myoblasts from skeletal muscle of an adult horse. The equine primary myoblas... Read More about Isolation, culturing and 3D bioprinting of equine myoblasts.

Anatomical Guide to the Paranasal Sinuses of Domestic Animals (2022)
Book Chapter
A.M. Alsafy, M., A.A. El-Gendy, S., & Sian Rutland, C. (2022). Anatomical Guide to the Paranasal Sinuses of Domestic Animals. In C. Rutland, & S. A. El-Gendy (Eds.), . InTech. https://doi.org/10.5772/intechopen.106157

Paranasal sinuses are paired cavities within the skull, which develop by evagination into the spongy bone between the external and internal plates of the cranial and facial bones. Thus, each sinus is lined by respiratory epithelium and has direct or... Read More about Anatomical Guide to the Paranasal Sinuses of Domestic Animals.

Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research (2022)
Journal Article
Jeyapalan, J. N., James, V., Gardner, D. S., Lothion-Roy, J. H., Mongan, N. P., & Rutland, C. S. (2022). Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anatomia, Histologia, Embryologia, https://doi.org/10.1111/ahe.12842

Research is often an essential component of completing a veterinary medicine degree, with universities worldwide aiming to teach students a variety of techniques and general research comprehension and skills. As universities worldwide navigated the C... Read More about Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research.

Effects of routine treatment with nonsteroidal anti-inflammatory drugs at calving and when lame on the future probability of lameness and culling in dairy cows: A randomized controlled trial (2022)
Journal Article
Wilson, J., Green, M., Randall, L., Rutland, C., Bell, N., Hemingway-Arnold, H., …Huxley, J. (2022). Effects of routine treatment with nonsteroidal anti-inflammatory drugs at calving and when lame on the future probability of lameness and culling in dairy cows: A randomized controlled trial. Journal of Dairy Science, 105(7), 6041-6054. https://doi.org/10.3168/jds.2021-21329

Claw horn lesions (CHL) are reported as the most common cause of lameness in intensive dairy systems. Despite their prevalence, the underlying pathological mechanisms and preventive strategies for CHL remain poorly understood. Recent advances have po... Read More about Effects of routine treatment with nonsteroidal anti-inflammatory drugs at calving and when lame on the future probability of lameness and culling in dairy cows: A randomized controlled trial.

Genetic Therapy in Veterinary Medicine (2022)
Journal Article
Zakirova, E. Y., Malanyeva, A. G., Rutland, C. S., & Aimaletdinov, A. M. (2022). Genetic Therapy in Veterinary Medicine. BioNanoScience, https://doi.org/10.1007/s12668-022-00986-y

Gene therapy focuses on the genetic modification of cells, to produce a therapeutic effect or for the treatment of disease, by repairing or reconstructing defective genetic material. The development of genetic engineering and biotechnology makes it p... Read More about Genetic Therapy in Veterinary Medicine.

Preclinical Research of Mesenchymal Stem Cell-Based Therapy for Ocular Diseases (2022)
Book Chapter
Zakirova, E., Aimaletdinov, A. M., Malanyeva, A. G., Rutland, С. S., & Rizvanov, A. A. (2022). Preclinical Research of Mesenchymal Stem Cell-Based Therapy for Ocular Diseases. . Springer Singapore. https://doi.org/10.1007/978-981-16-6016-0_12-1

Mesenchymal stem cells (MSC) are specific cell types that enable tissue renewal within the body and are activated during the regeneration processes in response to injury. These cells are present in all human and animal tissues. In medical and biologi... Read More about Preclinical Research of Mesenchymal Stem Cell-Based Therapy for Ocular Diseases.

Viral Vector Vaccines Against ASF: Problems and Prospectives (2022)
Journal Article
Ravilov, R. K., Rizvanov, A. A., Mingaleev, D. N., Galeeva, A. G., Zakirova, E. Y., Shuralev, E. A., …Efimova, M. A. (2022). Viral Vector Vaccines Against ASF: Problems and Prospectives. Frontiers in Veterinary Science, 9, Article 830244. https://doi.org/10.3389/fvets.2022.830244

African swine fever (ASF) is a highly contagious viral disease affecting pigs, with mortality rates a primary focus as they can reach up to 100%. The widespread and colossal economic losses from ASF have impacts on the development of animal husbandry... Read More about Viral Vector Vaccines Against ASF: Problems and Prospectives.

Health care providers’ awareness on medical management of children with autism spectrum disorder: cross-sectional study in Russia (2022)
Journal Article
Mukhamedshina, Y. O., Fayzullina, R. A., Nigmatullina, I. A., Rutland, C. S., & Vasina, V. V. (2022). Health care providers’ awareness on medical management of children with autism spectrum disorder: cross-sectional study in Russia. BMC Medical Education, 22, Article 29. https://doi.org/10.1186/s12909-021-03095-8

Background: Autism spectrum disorder (ASD) is a complex developmental range of conditions that involves difficulties with social interaction and restricted/repetitive behaviors. Unfortunately, health care providers often experience difficulties in di... Read More about Health care providers’ awareness on medical management of children with autism spectrum disorder: cross-sectional study in Russia.

Discovery Of A Bone In Chimpanzee Hearts (2022)
Journal Article
Sturrock, C. J., Stanford, K., Moittie, S., Baiker, K., Redrobe, S., & Rutland, C. S. (2022). Discovery Of A Bone In Chimpanzee Hearts. Frontiers for Young Minds, 9, Article 592105. https://doi.org/10.3389/frym.2021.592105

The os cordis (heart bone) is a rare bone found only in a few animals in the world. We discovered an os cordis in some chimpanzees. The os cordis was found in males and females, and in young and old animals. It was not present in chimps with healthy... Read More about Discovery Of A Bone In Chimpanzee Hearts.

Why Do We Need Maths in Medicine? (2021)
Journal Article
Cockcroft, J., Saigar, M., Dawkins, A., & Rutland, C. S. (2021). Why Do We Need Maths in Medicine?. Frontiers for Young Minds, 9, Article 678802. https://doi.org/10.3389/frym.2021.678802

Maths is a crucial part of medicine. All the graphs, equations, statistics, and general maths we learn at school help us to understand important aspects of human and veterinary medicine, biology, and science in general. People always think that biolo... Read More about Why Do We Need Maths in Medicine?.

Comparative pathology of dog and human prostate cancer (2021)
Journal Article
Ryman-Tubb, T., Lothion-Roy, J. H., Metzler, V. M., Harris, A. E., Robinson, B. D., Rizvanov, A. A., …de Brot, S. (2022). Comparative pathology of dog and human prostate cancer. Veterinary Medicine and Science, 8(1), 110-120. https://doi.org/10.1002/vms3.642

Though relatively rare in dogs, prostate cancer (PCa) is the most common non-cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been propos... Read More about Comparative pathology of dog and human prostate cancer.

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer (2021)
Journal Article
Filin, I. Y., Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2021). Recent Advances in Experimental Dendritic Cell Vaccines for Cancer. Frontiers in Oncology, 11, 1-7. https://doi.org/10.3389/fonc.2021.730824

The development of immunotherapeutic methods for the treatment of oncological diseases have made it possible to improve the effectiveness of standard therapies. There was no breakthrough after first using of personalized therapeutic vaccines based on... Read More about Recent Advances in Experimental Dendritic Cell Vaccines for Cancer.

Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection (2021)
Journal Article
Alsafy, M. A., Hanafy, B. G., Rutland, C. S., Karkoura, A. A., Enany, E.-S., & El-gendy, S. A. (2022). Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection. Morphologie, 106(355), 271-286. https://doi.org/10.1016/j.morpho.2021.08.001

The canine epigastric organs, their locations and visualization of these components are essential for veterinary practice and anatomical research. Despite their importance, conflicts and discrepancies in the published material, to date, still exist,... Read More about Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection.

Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma (2021)
Journal Article
Rutland, C. S., Cockcroft, J. M., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Simpson, S., …Mongan, N. P. (2021). Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma. Frontiers in Veterinary Science, 8, Article 704598. https://doi.org/10.3389/fvets.2021.704598

Osteosarcoma (OSA) is an aggressive bone malignancy. Unlike many other malignancies, OSA outcomes have not improved in recent decades. One challenge to the development of better diagnostic and therapeutic methods for OSA has been the lack of well cha... Read More about Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma.

A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions (2021)
Journal Article
Blanchard, A. M., Staley, C. E., Shaw, L., Wattegedera, S. R., Baumbach, C.-M., Michler, J. K., …Tötemeyer, S. (2021). A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions. Infection and Immunity, 89(10), Article e00270-21. https://doi.org/10.1128/iai.00270-21

Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s largest welfare problems. The complex etiology of footrot makes in situ or in vitro investigations difficult. Computational methods offer... Read More about A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.

Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors (2021)
Journal Article
Gatina, D. Z., Garanina, E. E., Zhuravleva, M. N., Synbulatova, G. E., Mullakhmetova, A. F., Solovyeva, V. V., …Salafutdinov, I. I. (2021). Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors. International Journal of Molecular Sciences, 22(11), Article 5922. https://doi.org/10.3390/ijms22115922

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and surgical treatments positively a... Read More about Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors.

Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy (2021)
Book Chapter
Simpson, S., Kordtomeikel, K.-Z., Wong, S., Bennison, S., El-Gendy, S. A., Cobb, M., & Rutland, C. S. (2021). Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy. In C. Rutland (Ed.), Canine Medicine : Recent Topics and Advanced Research (1-22). InTech. https://doi.org/10.5772/intechopen.97682

Dilated cardiomyopathy involves enlargement of the ventricular chamber and systolic dysfunction. The reduction in quality of life and increased levels of congestive heart failure, combined with the high diagnosis rate within the canine population, hi... Read More about Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy.

A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle (2021)
Journal Article
Wilson, J. P., Randall, L. V., Green, M. J., Rutland, C. S., Bradley, C. R., Ferguson, H. J., …Huxley, J. N. (2021). A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle. Journal of Dairy Science, 104(6), 7026-7038. https://doi.org/10.3168/jds.2020-19843

Claw horn lesions (CHL) are the result of a failing of the functional anatomy of the hoof in dairy cows. The digital cushion is understood to be a vital structure in the prevention of CHL. Claw horn lesions have previously been shown to lead to patho... Read More about A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle.

Skeleton Growth in Guinea Pigs and Humans (2021)
Journal Article
Skinner, Z., Clark, N., Rutland, S., Dawkins, A., & Rutland, C. S. (2021). Skeleton Growth in Guinea Pigs and Humans. Frontiers for Young Minds, 9, Article 561416

Every animal has a skeleton made up of many different bones. Bones are vital. Without bones we would not be able to move, protect our internal organs, store important minerals, or even make some cell types! When we are young, in addition to growing,... Read More about Skeleton Growth in Guinea Pigs and Humans.

Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age (2021)
Journal Article
Newsome, R. F., Mostyn, A., Wilson, J. P., Alibhai, A., Bollard, N., Randall, L., …Rutland, C. S. (2021). Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age. Journal of Dairy Science, 104(5), https://doi.org/10.3168/jds.2020-19388

The digital cushion is an essential part of maintaining a healthy foot, working to dissipate foot strike and body weight forces and lameness from claw horn disruption lesions. Despite the importance of the digital cushion, little is known about the b... Read More about Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age.

Current Trends in Cancer Immunotherapy (2020)
Journal Article
Filin, I. Y., Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Current Trends in Cancer Immunotherapy. Biomedicines, 8(12), 1-36. https://doi.org/10.3390/biomedicines8120621

The search for an effective drug to treat oncological diseases, which have become the main scourge of mankind, has generated a lot of methods for studying this affliction. It has also become a serious challenge for scientists and clinicians who have... Read More about Current Trends in Cancer Immunotherapy.

The Importance of Anatomy (2020)
Journal Article
Stanford, K., Rutland, S., Sturrock, C. J., & Rutland, C. S. (2020). The Importance of Anatomy. Frontiers for Young Minds, 8, Article 546763. https://doi.org/10.3389/frym.2020.546763

Anatomy is the knowledge about the structure of the bodies of animals and people. This includes information about blood vessels, organs, the skeleton, and nerves. But have you ever wondered where the anatomical information in science books and websit... Read More about The Importance of Anatomy.

Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors (2020)
Journal Article
Mavri, M., Spiess, K., Rosenkilde, M. M., Rutland, C. S., Vrecl, M., & Kubale, V. (2020). Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors. Molecules, 25(23), Article 5710. https://doi.org/10.3390/molecules25235710

Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeost... Read More about Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors.

Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine (2020)
Journal Article
Zakirova, E. Y., Aimaletdinov, A. M., Malanyeva, A. G., Rutland, C. S., & Rizvanov, A. A. (2020). Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine. Frontiers in Veterinary Science, 7, Article 594044. https://doi.org/10.3389/fvets.2020.594044

Extracellular vesicles are released by all cell types including stem cells. Stem cell-released extracellular vesicles have therapeutic effects similar to those of their parent cells and have regenerative effects in tissues. They also have an immunomo... Read More about Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine.

Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine (2020)
Journal Article
Gilazieva, Z., Ponomarev, A., Rutland, C., Rizvanov, A., & Solovyeva, V. (2020). Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine. Cancers, 12(10), Article 2727. https://doi.org/10.3390/cancers12102727

One of the promising directions in personalized medicine is the use of three-dimensional (3D) tumor models such as spheroids and organoids. Spheroids and organoids are three-dimensional cultures of tumor cells that can be obtained from patient tissue... Read More about Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine.

Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms (2020)
Journal Article
Blagotinšek Cokan, K., Mavri, M., Rutland, C. S., Glišić, S., Senćanski, M., Vrecl, M., & Kubale, V. (2020). Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms. Biomolecules, 10(10), Article 1355. https://doi.org/10.3390/biom10101355

The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the... Read More about Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms.

Molecular characterisation of canine osteosarcoma in high risk breeds (2020)
Journal Article
Simpson, S., Dunning, M., de Brot, S., Alibhai, A., Bailey, C., Woodcock, C. L., …Rutland, C. S. (2020). Molecular characterisation of canine osteosarcoma in high risk breeds. Cancers, 12(9), Article 2405. https://doi.org/10.3390/cancers12092405

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dogs develop osteosarcoma (OSA) and the disease process closely resembles that of human OSA. OSA has a poor prognosis in both species and disease-free intervals and cure rates have not improve... Read More about Molecular characterisation of canine osteosarcoma in high risk breeds.

Can Toothache Cause Heartbreak? (2020)
Journal Article
Clark, N., Skinner, Z., & Rutland, C. S. (2020). Can Toothache Cause Heartbreak?. Frontiers for Young Minds, 8, Article 87. https://doi.org/10.3389/frym.2020.00087

Poor mouth care and heart disease are two major health concerns worldwide. Both conditions occur in humans and in many mammals, including our pets. “Periodontal” is the word used to refer to structures surrounding the teeth, including the gums and bo... Read More about Can Toothache Cause Heartbreak?.

Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses (2020)
Book Chapter
Zakirova, E., Milomir, K., Zhuravleva, M., Rutland, C., & Rizvanov, A. (2020). Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses. In C. Rutland, & A. Rizvanov (Eds.), Equine science. InTech. https://doi.org/10.5772/intechopen.92352

Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that ha... Read More about Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses.

Mouse Tumor Models for Advanced Cancer Immunotherapy (2020)
Journal Article
Chulpanova, D. S., Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2020). Mouse Tumor Models for Advanced Cancer Immunotherapy. International Journal of Molecular Sciences, 21(11), Article 4118. https://doi.org/10.3390/ijms21114118

Recent advances in the development of new methods of cancer immunotherapy require the production of complex cancer animal models that reliably reflect the complexity of the tumor and its microenvironment. Mice are good animals to create tumor models... Read More about Mouse Tumor Models for Advanced Cancer Immunotherapy.

The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy (2020)
Book Chapter
Kubale, V., Prozorowska, E., Glocová, K., Slater, L., & Rutland, C. (2020). The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy. In D. Gaze (Ed.), . United Kingdom: IntechOpen. https://doi.org/10.5772/intechopen.92628

The G-protein-coupled receptors (GPCRs, also called seven-transmembrane receptor, 7TMRs, or heptahelical receptor) are a conserved family of seven transmembrane receptors which are essential not only in the healthy heart and blood vessels but also in... Read More about The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy.

Epidemiology and risk factors of osteosarcoma (2020)
Journal Article
Sadykova, L. R., Ntekim, A. I., Muyangwa-Semenova, M., Rutland, C. S., Jeyapalan, J. N., Blatt, N., & Rizvanov, A. (2020). Epidemiology and risk factors of osteosarcoma. Cancer Investigation, 38(5), 259-269. https://doi.org/10.1080/07357907.2020.1768401

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma, particularly race and gender. Although diagnosed worldwide, oste... Read More about Epidemiology and risk factors of osteosarcoma.

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening (2020)
Journal Article
Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Cell Culture Based in vitro Test Systems for Anticancer Drug Screening. Frontiers in Bioengineering and Biotechnology, 8, Article 322. https://doi.org/10.3389/fbioe.2020.00322

The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of t... Read More about Cell Culture Based in vitro Test Systems for Anticancer Drug Screening.

Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys (2019)
Journal Article
El-Gendy, S. A., Alsafy, M. A., Rutland, C. S., EL-Khamary, A. N., Abu-Ahmed, H. M., & El-Kammar, M. H. (2020). Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys. Journal of Equine Veterinary Science, 88, Article 102904. https://doi.org/10.1016/j.jevs.2019.102904

The donkey is of socio-economic value yet imaging techniques in both healthy and abnormal limbs are a limiting factor in research and medicine. The objective was to determine anatomical features of both healthy and clinically abnormal donkey metacarp... Read More about Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys.

Production and Application of Multicistronic Constructs for Various Human Disease Therapies (2019)
Journal Article
Shaimardanova, A. A., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., …Solovyeva, V. V. (2019). Production and Application of Multicistronic Constructs for Various Human Disease Therapies. Pharmaceutics, 11, 580. https://doi.org/10.3390/pharmaceutics11110580

The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the exampl... Read More about Production and Application of Multicistronic Constructs for Various Human Disease Therapies.

Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo (2019)
Journal Article
Faidra Angelerou, M. G., Markus, R., Paraskevopoulou, V., Foralosso, R., Clarke, P., Alvarez, C. V., …Marlow, M. (2020). Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo. Journal of Controlled Release, 317, 118-129. https://doi.org/10.1016/j.jconrel.2019.10.011

Supramolecular gels have recently emerged as promising biomaterials for the delivery of a wide range of bioactive molecules, from small hydrophobic drugs to large biomolecules such as proteins. Although it has been demonstrated that each encapsulated... Read More about Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo.

Potential therapeutic application of mesenchymal stem cells in ophthalmology (2019)
Journal Article
Zakirova, E. Y., Valeeva, A., Aimaletdinov, A., Nefedovskaya, L., Akhmetshin, R., Rutland, C., & Rizvanov, A. (2019). Potential therapeutic application of mesenchymal stem cells in ophthalmology. Experimental Eye Research, 189, Article 107863. https://doi.org/10.1016/j.exer.2019.107863

At present a wide variety of methods have been proposed to treat eye disorders, drug therapies are most commonly used. It should be noted that effective treatment modalities especially for degeneration of the retina and optic nerve are lacking. In th... Read More about Potential therapeutic application of mesenchymal stem cells in ophthalmology.

Physics of animal health: on the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., …Rauch, C. (2019). Physics of animal health: on the mechano-biology of hoof growth and form. Interface, 16(155), 1-12. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of animal health: on the mechano-biology of hoof growth and form.

Use of biologically active 3D matrix for extensive skin defect treatment in veterinary practice: case report (2019)
Journal Article
Zakirova, E. Y., Shalimov, D. V., Garanina, E. E., Zhuravleva, M. N., Rutland, C. S., & Rizvanov, A. A. (2019). Use of biologically active 3D matrix for extensive skin defect treatment in veterinary practice: case report. Frontiers in Veterinary Science, 6, Article 76. https://doi.org/10.3389/fvets.2019.00076

Objectives: Large full-thickness skin defects represent a serious veterinary problem. Methods: We have developed novel bioactive 3D-matrixes based on fibrin glue Tissucol (Baxter), containing the combination of the adenoviral constructs with genes v... Read More about Use of biologically active 3D matrix for extensive skin defect treatment in veterinary practice: case report.

Reptilian skin and its special histological structures (2019)
Book Chapter
Rutland, C. S., Cigler, P., & Kubale Dvojmoč, V. (2019). Reptilian skin and its special histological structures. In C. S. Rutland, & V. Kubale Dvojmoč (Eds.), Veterinary anatomy and physiology (1-21). InTech. https://doi.org/10.5772/intechopen.84212

Reptilian skin is covered with scales forming armor that makes it watertight and enables reptiles to live on land in contrast to amphibians. An important part of the skin is the horny epidermis, with thick stratum corneum in which waxes are arranged... Read More about Reptilian skin and its special histological structures.

Veterinary anatomy and physiology (2019)
Book
Rutland, C. S., & Kubale Dvojmoč, V. (Eds.). (2019). Veterinary anatomy and physiology. InTech

Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the anima... Read More about Veterinary anatomy and physiology.

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. https://doi.org/10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More about Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment.

The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof (2019)
Book Chapter
Al-Agele, R., Paul, E., Kubale Dvojmoc, V., Sturrock, C. J., Rauch, C., & Rutland, C. S. (2019). The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof. In Veterinary Anatomy and Physiology. IntechOpen. https://doi.org/10.5772/intechopen.84514

Satisfactory investigations of the equine foot appear to be limited by the histomorphological complexity of internal hoof structures. Foot lameness is considered to be one of the most debilitating pathological disorders of the equine foot. In most sp... Read More about The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof.

Avian Cardiovascular Disease Characteristics, Causes and Genomics (2018)
Book Chapter
Kubale, V., Merry, K., Miller, G., Ruiz Diaz, M., & Rutland, C. (2018). Avian Cardiovascular Disease Characteristics, Causes and Genomics. In X. Liu (Ed.), Application of genetics and genomics in poultry science (141-162). London: InTech. https://doi.org/10.5772/intechopen.78005

Cardiovascular disease is common in avian species and increasing commercial economic losses and demand for healthcare in the household/smallholding veterinary sector has resulted in increased research into these disorders. This in turn has highlighte... Read More about Avian Cardiovascular Disease Characteristics, Causes and Genomics.

Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses (2018)
Journal Article
Kovac, M., Litvin, Y. A., Aliev, R. O., Zakirova, E. Y., Rutland, C. S., Kiyasov, A. P., & Rizvanov, A. A. (2018). Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses. Frontiers in Pharmacology, 9, https://doi.org/10.3389/fphar.2018.00978

This clinical study describes the intralesional application of the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor (VEGF164) and fibroblast growth factor 2 (FGF2) in seven horses to restore nat... Read More about Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses.

Mending a broken heart—the genetics of heart disease (2018)
Journal Article
Clark, N., Alibhai, A., & Rutland, C. S. (2018). Mending a broken heart—the genetics of heart disease. Frontiers for Young Minds, 6, Article 19. https://doi.org/10.3389/frym.2018.00019

Heart disease is a major cause of health problems worldwide. There are many different types of heart disease, but one that is fairly common and can have lots of negative side effects is called cardiomyopathy. We know that humans and many mammals, inc... Read More about Mending a broken heart—the genetics of heart disease.

Peri-conception and first trimester diet modifies reproductive development in bulls (2017)
Journal Article
Copping, K. J., Ruiz-Diaz, M. D., Rutland, C. S., Mongan, N. P., Callaghan, M., McMillen, I. C., …Perry, V. (in press). Peri-conception and first trimester diet modifies reproductive development in bulls. Reproduction, Fertility and Development, https://doi.org/10.1071/RD17102

Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto–placental unit and its response to dietary perturbations is dissimilar to that of these speci... Read More about Peri-conception and first trimester diet modifies reproductive development in bulls.

Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer (2017)
Book Chapter
Rutland, C. S., de Brot, S., James, V., & Mongan, N. P. (2018). Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs (359-372). Elsevier. https://doi.org/10.1016/b978-0-12-811022-5.00019-x

In eukaryotes, the packaging of DNA and proteins, termed chromatin, is an essential determinant of transcription. The basic unit of chromatin, the nucleosome, is composed of ∼146 base pairs of DNA spooled around a dense protein core containing two co... Read More about Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer.

Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports (2017)
Journal Article
Kovac, M., Litvin, Y. A., Aliev, R. O., Zakirova, E. Y., Rutland, C. S., Kiyasov, A., & Rizvanov, A. A. (2017). Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports. Frontiers in Veterinary Science, 4(168), https://doi.org/10.3389/fvets.2017.00168

In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therape... Read More about Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports.

Skull of the grey heron (Ardea cinerea ): detailed investigation of the orbital region (2017)
Journal Article
Bavdek, S., Golob, Z., Janžekovič, F., Rutland, C. S., & Kubale, V. (2017). Skull of the grey heron (Ardea cinerea ): detailed investigation of the orbital region. Anatomia, Histologia, Embryologia, 46(6), 552-557. https://doi.org/10.1111/ahe.12308

The skull of the grey heron (Ardea cinerea) was examined with an emphasis on describing the orbital region. In the young (circa sixteen to seventeen days old) heron, the frontal bone (os frontale) and nasal bone (os nasale) comprised separate paired... Read More about Skull of the grey heron (Ardea cinerea ): detailed investigation of the orbital region.

Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies (2017)
Journal Article
Ruiz-Diaz, M. D., Partridge, H., Davidson, F., Mongan, N. P., Gardner, D. S., & Rutland, C. S. (2017). Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies. European Medical Journal Reproductive Health, 3(1),

It is well known that consumption of a balanced diet throughout adulthood is key toward maintenance of optimal body weight and cardiovascular health. Research using animal models can provide insights into the programming of short and long-term health... Read More about Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies.

Computed tomography in veterinary medicine: currently published and tomorrow’s vision (2017)
Book Chapter
Keane, M., Paul, E., Sturrock, C., Rauch, C., & Rutland, C. S. (in press). Computed tomography in veterinary medicine: currently published and tomorrow’s vision. In A. M. Halefoğlu (Ed.), Computed tomography: advanced applications. InTechOpen. https://doi.org/10.5772/intechopen.68556

The utilisation of Computed Tomography (CT) in veterinary practice has been increasing rapidly in line with reduced cost, improved availability and the increase in expertise and technology. This review briefly examines the recent technological advanc... Read More about Computed tomography in veterinary medicine: currently published and tomorrow’s vision.

Unique characterisation of Langerhans cells in the spleen of the African catfish (Clarias gariepinus) (2017)
Journal Article
Zaghloul, D. M., Derbalah, A., & Rutland, C. S. (2017). Unique characterisation of Langerhans cells in the spleen of the African catfish (Clarias gariepinus). https://doi.org/10.19185/matters.201703000005

The African catfish (Clarias gariepinus) has increasingly become an economically important food source especially in Africa, Asia and Europe, with exports extending to countries throughout the world. In the last 25 years, aquaculture of this species... Read More about Unique characterisation of Langerhans cells in the spleen of the African catfish (Clarias gariepinus).

Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy (2017)
Journal Article
England, J., Loughna, S., & Rutland, C. S. (2017). Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy. Journal of Cardiovascular Development and Disease, 4(3), Article 8. https://doi.org/10.3390/jcdd4030008

Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animal... Read More about Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy.

Fatty acids in veterinary medicine and research (2017)
Book Chapter
Rutland, C. S., Mostyn, A., & Simpson, S. (2017). Fatty acids in veterinary medicine and research. In A. Catala (Ed.), Fatty acids. InTechOpen. https://doi.org/10.5772/intechopen.68440

Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the bo... Read More about Fatty acids in veterinary medicine and research.

Morphological and structural investigations of Egyptian water buffalo (Bubalus Bubalis) sertoli cells (2017)
Journal Article
Rutland, C. S., Derbalah, A., Karam Roshdy, K., & El-Gendy, S. (2017). Morphological and structural investigations of Egyptian water buffalo (Bubalus Bubalis) sertoli cells. Journal of Buffalo Science, 6(1), https://doi.org/10.6000/1927-520X.2017.06.01.1

Buffaloes are essential part of the economy in many countries and provide sustainable food in addition to being working animals. Inefficiency in reproduction has become problematic in recent years due to a number of factors and although much research... Read More about Morphological and structural investigations of Egyptian water buffalo (Bubalus Bubalis) sertoli cells.

Genomic insights into cardiomyopathies: a comparative cross-species review (2017)
Journal Article
Simpson, S., Rutland, P., & Rutland, C. S. (2017). Genomic insights into cardiomyopathies: a comparative cross-species review. Veterinary Sciences, 4(1), Article 19. https://doi.org/10.3390/vetsci4010019

n the global human population, the leading cause of non-communicable death is cardiovascular disease. It is predicted that by 2030, deaths attributable to cardiovascular disease will have risen to over 20 million per year. This review compares the ca... Read More about Genomic insights into cardiomyopathies: a comparative cross-species review.

The Effects of Diet on Anatomy, Physiology and Health in the Guinea Pig (2016)
Journal Article
Witkowska, A., Price, J., Hughes, C., Smith, D., White, K., Alibhai, A., & Rutland, C. S. (2017). The Effects of Diet on Anatomy, Physiology and Health in the Guinea Pig. Journal of Animal Health and Behavioural Science, 1(1), 1-6

Given the increasing popularity of the guinea pig as a pet, it is perhaps surprising that relatively little is published as to their husbandry and dietary requirements. Indeed, a review of the literature currently available to owners, scientists and... Read More about The Effects of Diet on Anatomy, Physiology and Health in the Guinea Pig.

Multiple genetic associations with Irish wolfhound dilated cardiomyopathy (2016)
Journal Article
Simpson, S., Dunning, M. D., Brownlie, S., Patel, J., Godden, M., Cobb, M., …Rutland, C. S. (2016). Multiple genetic associations with Irish wolfhound dilated cardiomyopathy. BioMed Research International, 2016(637408), https://doi.org/10.1155/2016/6374082

Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with gene... Read More about Multiple genetic associations with Irish wolfhound dilated cardiomyopathy.

How does student educational background affect transition into the first year of veterinary school? Academic performance and support needs in university education (2016)
Journal Article
Rutland, C. S., Dobbs, H., & Tötemeyer, S. (in press). How does student educational background affect transition into the first year of veterinary school? Academic performance and support needs in university education. Journal of Veterinary Medical Education, 43(4), https://doi.org/10.3138/jvme.0915-145R1

The first year of university is critical in shaping persistence decisions (whether students continue with and complete their degrees) and plays a formative role in influencing student attitudes and approaches to learning. Previous educational experie... Read More about How does student educational background affect transition into the first year of veterinary school? Academic performance and support needs in university education.

Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age (2016)
Journal Article
Miguel-Pacheco, G., Curtain, L., Rutland, C. S., Knott, L., Norman, S., Phillips, N., & Perry, V. (2017). Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age. Animal, 11(6), 991-999. https://doi.org/10.1017/S1751731116002330

Genetically similar nulliparous Polled Hereford heifers from a closed pedigree herd were used to evaluate the effects of dietary protein during the first and second trimester of gestation upon fetal, placental and postnatal growth. Heifers were rando... Read More about Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age.

Genetics of human and canine dilated cardiomyopathy (2015)
Journal Article
Simpson, S., Edwards, J., Ferguson-Mignan, T. F., Cobb, M., Mongan, N. P., & Rutland, C. S. (2015). Genetics of human and canine dilated cardiomyopathy. International Journal of Genomics, 2015, Article 204823. https://doi.org/10.1155/2015/204823

Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in... Read More about Genetics of human and canine dilated cardiomyopathy.

Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development. (2014)
Journal Article
Witkowska, A., Alibhai, A., Hughes, C., Price, J., Klisch, K., Sturrock, C., & Rutland, C. S. (2014). Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development. PeerJ, 2, Article e615. https://doi.org/10.7717/peerj.615

The domestic guinea pig, Cavia aperea f. porcellus, belongs to the Caviidae family of rodents. It is an important species as a pet, a source of food and in medical research. Adult weight is achieved at 8-12 months and life expectancy is ∼5-6 years. O... Read More about Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development..

Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart (2011)
Journal Article
Rutland, C. S., Polo-Parada, L., Ehler, E., Alibhai, A., Thorpe, A., Suren, S., …Loughna, S. (2011). Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart. Development, 138(18), https://doi.org/10.1242/dev.059063

The expression and function of embryonic myosin heavy chain (eMYH) has not been investigated within the early developing heart. This is despite the knowledge that other structural proteins, such as alpha and beta myosin heavy chains and cardiac alpha... Read More about Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis (2009)
Journal Article
Rutland, C., Warner, L., Thorpe, A., Alibhai, A., Robinson, T., Shaw, B., …Loughna, S. (2009). Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy, 214(6), 905-915. https://doi.org/10.1111/j.1469-7580.2009.01079.x

Atrial septal defects are a common congenital heart defect in humans. Although mutations in different genes are now frequently being described, little is known about the processes and mechanisms behind the early stages of atrial septal development. B... Read More about Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.