Professor CATRIN RUTLAND's Outputs (140)

Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review (2025)
Journal Article
Kubale, V., Best, A., Mai, S., Smale, T., Alibhai, A., Perez, W., A.A. El-Gendy, S., A.M. Alsafy, M., J. Sturrock, C., & Sian Rutland, C. (2025). Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review. Cells Tissues Organs, https://doi.org/10.1159/000544776

Introduction:

The cartilago cordis is a structure present within the cardiac skeleton of some, but not all, vertebrate species. This systematic review compared the presence, structure, and function of the cartilago cordis from published works cov... Read More about Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review.

Cardiotoxicity of breast cancer drug treatments (2025)
Journal Article
Haque, M., Atallah, N., Patke, R., Harris, A. E., Woodcock, C. L., Varun, D., Thompson, R. L., Jackson-Oxley, J., Okui, C. H., Dean, A., Alsaleem, M., Rakha, E., Irshad, S., Davis, M. B., Jeyapalan, J. N., Mongan, N. P., & Rutland, C. S. (2025). Cardiotoxicity of breast cancer drug treatments. Translational Oncology, 55, Article 102352. https://doi.org/10.1016/j.tranon.2025.102352

Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. BC is regarded as a systemic disease. Consequently, the majority of BC patients undergo systemic therapy to reduce the risk of distant metastasis (DM) and associ... Read More about Cardiotoxicity of breast cancer drug treatments.

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2025)
Journal Article
Kovac, M., Berestov, I. V., Aimaletdinov, A. M., Rutland, C. S., Rizvanov, A. A., & Zakirova, E. Y. (2025). Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports. Opera Medica et Physiologica, 11(2), 74-89. https://doi.org/10.24412/2500-2295-2024-2-74-89

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

Immunohistochemical and Histomorphometric Related Small Intestine Changes Associated With Sodium Butyrate Supplement in Chickens (2025)
Journal Article
Alsafy, M. A., Ez Elarab, S. M., Abdellatif, I. A., Elewa, Y. H., Basha, H. A., Bassuoni, N. F., El-Gendy, S. A., Abumandour, M. A., Rutland, C., & Roshdy, K. (2025). Immunohistochemical and Histomorphometric Related Small Intestine Changes Associated With Sodium Butyrate Supplement in Chickens. Slovenian Veterinary Research, 61(2), 1-13. https://doi.org/10.26873/svr-2033-2024

This study evaluated the effects of sodium butyrate (SB) supplementation on small intestine development in broiler chickens. Periodic acid-Schiff (PAS) and immunohistochemistry were used to undertake histological examinations of the duodenum, jejunum... Read More about Immunohistochemical and Histomorphometric Related Small Intestine Changes Associated With Sodium Butyrate Supplement in Chickens.

The effect of non-steroidal anti-inflammatory drugs, therapeutic hoof trimming and orthopedic block application on lameness in multiparous dairy cattle, a randomized controlled trial (2025)
Journal Article
Wilson, J., Green, M., Randall, L., Rutland, C., Bell, N., Hemingway-Arnold, H., Thompson, J., Bollard, N., & Huxley, J. (2025). The effect of non-steroidal anti-inflammatory drugs, therapeutic hoof trimming and orthopedic block application on lameness in multiparous dairy cattle, a randomized controlled trial. Journal of Dairy Science, https://doi.org/10.3168/jds.2024-25442

Hoof horn lesions are recurrent in nature and cause long-term pathological challenges to the functional anatomy of the hoof in dairy cattle. It is hypothesized that inflammation is a driver of these pathological changes. It has previously been identi... Read More about The effect of non-steroidal anti-inflammatory drugs, therapeutic hoof trimming and orthopedic block application on lameness in multiparous dairy cattle, a randomized controlled trial.

Structural investigations of the normal ostrich head using anatomical sections, computed tomography, and magnetic resonance imaging (2024)
Journal Article
Aref, M., Abd El Raouf, M., Youssef, W. O., Abdelbaset-Ismail, A., Salem, G. A., Nassan, M. A., Rutland, C. S., & Mahdy, E. A. (2024). Structural investigations of the normal ostrich head using anatomical sections, computed tomography, and magnetic resonance imaging. Open Veterinary Journal, 14(12), 3487-3497. https://doi.org/10.5455/OVJ.2024.v14.i12.32

Background:

The significance of the ostrich (Struthio camelus) has increased recently due to the growth of the global ostrich farming industry.

Aim:

Morphological and diagnostic imaging of the ostrich head presents challenges for enhancing c... Read More about Structural investigations of the normal ostrich head using anatomical sections, computed tomography, and magnetic resonance imaging.

Teaching of Anatomy: Dissecting Dissection in Veterinary and Medical Education from a Historical Perspective through to Today (2024)
Journal Article
Kubale, V., Perez, W., & Rutland, C. S. (2024). Teaching of Anatomy: Dissecting Dissection in Veterinary and Medical Education from a Historical Perspective through to Today. Slovenian Veterinary Research, 61(4), 225-232. https://doi.org/10.26873/SVR-2167-2024

As veterinary and human medicine education evolves, instructors can now incorporate a range of innovative anatomy tools, from low-fidelity models to high-fidelity simulators, 3D printing, dissection software, and augmented/virtual reality. However, c... Read More about Teaching of Anatomy: Dissecting Dissection in Veterinary and Medical Education from a Historical Perspective through to Today.

Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights (2024)
Journal Article
Smith, F., Kotowska, A. M., Fiedler, B., Cerny, E., Cheung, K., Rutland, C. S., Chowdhury, F., Segal, J., Rawson, F. J., & Marlow, M. (2025). Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights. Molecular Pharmaceutics, 22(1), 316-329. https://doi.org/10.1021/acs.molpharmaceut.4c00942

Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid... Read More about Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights.

Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy (2024)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mather, M. L., Alsaleem, M., Bateman-Price, T. D., Patke, R., Ball, G., Mongan, N. P., & Rakha, E. (2025). Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy. Journal of Microscopy, 297(2), 135-152. https://doi.org/10.1111/jmi.13361

Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of the tumour stroma in BC remains to be defined. Di... Read More about Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.

Microstructural architecture of the bony scutes, spine, and rays of the bony fins in the common pleco (Hypostomus plecostomus) (2024)
Journal Article
Abd-Elhafeez, H. H., Massoud, D., Mahmoud, M. S., Abdellah, N., Salah, A. S., Mohamed, N.-E., Ali Abdelrhman Sayed, M., Shaalan, M., Rutland, C. S., Sayed Abu-ELhamed, A., Soliman, S. A., & El-Zahraa A. Mustafa, F. (2024). Microstructural architecture of the bony scutes, spine, and rays of the bony fins in the common pleco (Hypostomus plecostomus). International Journal of Veterinary Science and Medicine, 12(1), 101-124. https://doi.org/10.1080/23144599.2024.2374201

Studying scute and fin morphology are advantageous approaches for phylogenetic identification and provide information on biological linkages and evolutionary history that are essential for deciphering the fossil record. Despite this, no prior researc... Read More about Microstructural architecture of the bony scutes, spine, and rays of the bony fins in the common pleco (Hypostomus plecostomus).

The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes (2024)
Journal Article
Ghannam, S. F., Makhlouf, S., Alsaleem, M., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. A. (2024). The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes. Modern Pathology, 37(12), Article 100607. https://doi.org/10.1016/j.modpat.2024.100607

The tumor microenvironment plays a key role in tumor progression. The proportion of the stroma-to-tumor cells (stroma-tumor ratio [STR]) has a variable prognostic significance in breast cancer (BC) molecular classes. In this study, we evaluated the m... Read More about The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes.

Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer (2024)
Journal Article
Lashen, A. G., Toss, M. S., Rutland, C. S., Green, A. R., Mongan, N. P., & Rakha, E. (2025). Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer. Pathobiology, 92(1), 18-27. https://doi.org/10.1159/000540790

Introduction: Minichromosome maintenance complex component 7 (MCM7) plays an essential role in proliferation and DNA replication of cancer cells. However, the expression and prognostic significance of MCM7 in breast cancer (BC) remain to be defined.... Read More about Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer.

The role of the ALKBH5 RNA demethylase in invasive breast cancer (2024)
Journal Article
Woodcock, C. L., Alsaleem, M., Toss, M. S., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Blatt, N., Rizvanov, A. A., Miftakhova, R. R., Kariri, Y. A., Madhusudan, S., Green, A. R., Rutland, C. S., Fray, R. G., Rakha, E. A., & Mongan, N. P. (2024). The role of the ALKBH5 RNA demethylase in invasive breast cancer. Discover Oncology, 15(1), Article 343. https://doi.org/10.1007/s12672-024-01205-8

Background: N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological mechanism... Read More about The role of the ALKBH5 RNA demethylase in invasive breast cancer.

Advances in Soft Tissue and Bone Sarcoma (2024)
Journal Article
Rutland, C. (2024). Advances in Soft Tissue and Bone Sarcoma. Cancers, 16(16), Article 2875. https://doi.org/10.3390/cancers16162875

Epitranscriptomic mechanisms of androgen signalling and prostate cancer (2024)
Journal Article
Patke, R., Harris, A. E., Woodcock, C. L., Thompson, R., Santos, R., Kumari, A., Allegrucci, C., Archer, N., Gudas, L. J., Robinson, B. D., Persson, J. L., Fray, R., Jeyapalan, J., Rutland, C. S., Rakha, E., Madhusudan, S., Emes, R. D., Muyangwa-Semenova, M., Alsaleem, M., de Brot, S., …Lothion-Roy, J. (2024). Epitranscriptomic mechanisms of androgen signalling and prostate cancer. Neoplasia, 56, Article 101032. https://doi.org/10.1016/j.neo.2024.101032

Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen... Read More about Epitranscriptomic mechanisms of androgen signalling and prostate cancer.

The characteristics and prognostic significance of histone H1 expression in breast cancer (2024)
Journal Article
Lashen, A. G., Almalki, N., Toss, M., Mirza, S., Malki, M. I., Rutland, C. S., Jeyapalan, J. N., Green, A. R., Mongan, N. P., Madhusudan, S., & Rakha, E. A. (2024). The characteristics and prognostic significance of histone H1 expression in breast cancer. Pathology, 56(6), 826-833. https://doi.org/10.1016/j.pathol.2024.03.012

Histone H1 (H.H1) is involved in chromatin organisation and gene regulation and is overexpressed in many malignant tumours, including breast cancer (BC). This study proposed and evaluated the prognostic role of H.H1 expression in BC.

H.H1 mRNA exp... Read More about The characteristics and prognostic significance of histone H1 expression in breast cancer.

Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis (2024)
Journal Article
Alsafy, M. A. M., El-Gendy, S. A. A., Atkinson, B., Sturrock, C. J., Kamal, B. M., Alibhai, A., Abd-Elhafeez, H. H., Soliman, S., Rashwan, A. M., Roshdy, K., & Rutland, C. S. (2024). Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis. Microscopy and Microanalysis, 30(3), 574-593. https://doi.org/10.1093/mam/ozae046

Ossa cordis, bones located within the heart trigones, are often classified as heterotopic or ectopic bones. Despite their high prevalence in cattle and some other bovids, little is known about their structure or development. Scanning electron microsc... Read More about Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis.

Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma (2024)
Journal Article
de Brot, S., Cobb, J., Alibhai, A. A., Jackson-Oxley, J., Haque, M., Patke, R., Harris, A. E., Woodcock, C. L., Lothion-Roy, J., Varun, D., Thompson, R., Gomes, C., Kubale, V., Dunning, M. D., Jeyapalan, J. N., Mongan, N. P., & Rutland, C. S. (2024). Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma. Cancers, 16(10), Article 1945. https://doi.org/10.3390/cancers16101945

Osteosarcoma (OSA) is the most common type of primary bone malignancy in people and dogs. Our previous molecular comparisons of canine OSA against healthy bone resulted in the identification of differentially expressed protein-expressing genes (forkh... Read More about Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma.

Subconjunctival Use of Mesenchymal Stem Cells for the Treatment of Canine Ulcerative Keratitis (2024)
Journal Article
Valeeva, A. N., Malanyeva, A., Rutland, C. S., Aimaletdinov, A. M., & Zakirova, E. Y. (2024). Subconjunctival Use of Mesenchymal Stem Cells for the Treatment of Canine Ulcerative Keratitis. Opera Medica et Physiologica, 11(1), 94-102. https://doi.org/10.24412/2500-2295-2024-1-94-102

Ophthalmic diseases are common problems in dogs of various breeds and ages. In recent years, ophthalmologists have been paying more attention to stem cell (SC) therapies, since the renewal and regeneration of any tissue in the adult body depends on s... Read More about Subconjunctival Use of Mesenchymal Stem Cells for the Treatment of Canine Ulcerative Keratitis.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., Peffers, M. J., Mongan, N. P., Arkill, K. P., Ritchie, A., Clarke, P. A., Ratan, H., Allegrucci, C., Grabowska, A. M., & James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.