Professor JONATHAN AYLOTT's Outputs (4)

Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes (2016)
Journal Article
Rawson, F. J., Cole, M., Aylott, J. W., Milne, W., Collins, C., Jackson, S. K., Silman, N., Mendes, P. M., & Hicks, J. (in press). Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes. Scientific Reports, 6(37672), https://doi.org/10.1038/srep37672

With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particula... Read More about Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes.

Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors (2016)
Journal Article
Chauhan, V. M., Giuntini, F., & Aylott, J. W. (2016). Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors. Sensing and Bio-Sensing Research, 8, https://doi.org/10.1016/j.sbsr.2016.03.007

Nanosensors capable of simultaneously measuring dissolved oxygen concentrations from 0 to 100% saturation and pH over the full physiological range, from pH 3.5 to 7.5, that advance the methods towards understanding of key biological gradients, were s... Read More about Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors.

Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition (2016)
Journal Article
Canning, A., Pasquazi, A., Fijten, M., Rajput, S., Buttery, L., Aylott, J. W., & Zelzer, M. (2016). Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition. Journal of Polymer Science Part A: Polymer Chemistry, 54(15), 2331-2336. https://doi.org/10.1002/pola.28104

Ring opening polymerization (ROP) of N‐carboxy anhydride (NCA) amino acids presents a rapid way to synthesize high molecular weight polypeptides with different amino acid compositions. The compositional and functional versatility of polypeptides make... Read More about Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition.

Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release (2016)
Journal Article
Wren, S. A. C., Aylott, J. W., Tres, F., Treacher, K., Booth, J., Hughes, L. P., Wren, S. A., Aylott, J., & Burley, J. C. (2016). Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release. Molecular Pharmaceutics, 13(3), 1166-1175. https://doi.org/10.1021/acs.molpharmaceut.5b00979

© 2016 American Chemical Society. Because of its weakly acidic nature (pKa of 4.5), indomethacin presents an aqueous solubility that significantly increases when changing from acidic to neutral/alkaline pH (1.5 μg/mL at pH 1.2 and 105.2 μg/mL at pH 7... Read More about Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release.