Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes

Rawson, Frankie J.; Cole, M.T; Aylott, Jonathan W.; Milne, W.I.; Collins, C.M.; Jackson, Simon K.; Silman, Nigel; Mendes, Paula M.; Hicks, Jacqueline

Abstract

With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolecules for highly sensitive and selective biosensing, shedding new light on cellular behaviour. Towards this aim, herein we interface cells with patterned nano-arrays of carbon nanofibers forming a nanosensor-cell construct. We show that such a construct is capable of electrochemically communicating with the intracellular environment.

Citation

Rawson, F. J., Cole, M., Aylott, J. W., Milne, W., Collins, C., Jackson, S. K., Silman, N., Mendes, P. M., & Hicks, J. (in press). Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes. Scientific Reports, 6(37672), https://doi.org/10.1038/srep37672

• Journal Article Type: Article
• Acceptance Date: Nov 1, 2016
• Online Publication Date: Dec 1, 2016
• Deposit Date: Jan 13, 2017
• Publicly Available Date: Jan 13, 2017
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 37672
• DOI: https://doi.org/10.1038/srep37672
• Public URL: https://nottingham-repository.worktribe.com/output/825794
• Publisher URL: http://www.nature.com/articles/srep37672
• Contract Date: Jan 13, 2017