Professor AMIR GHAEMMAGHAMI's Outputs (10)

High-throughput approaches for screening and analysis of cell behaviors (2017)
Journal Article
Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Camci-Unal, G., Dikina, A. D., Brinegar, K., Ghaemmaghami, A. M., Alsberg, E., & Khademhosseini, A. (2018). High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153, 85-101. https://doi.org/10.1016/j.biomaterials.2017.06.022

The rapid development of new biomaterials and techniques to modify them challenge our capability to characterize them using conventional methods. In response, numerous high-throughput (HT) strategies are being developed to analyze biomaterials and th... Read More about High-throughput approaches for screening and analysis of cell behaviors.

Integrin-mediated interactions control macrophage polarization in 3D hydrogels (2017)
Journal Article
Cha, B.-H., Shin, S. R., Leijten, J., Li, Y.-C., Singh, S., Liu, J. C., Annabi, N., Abdi, R., Dokmeci, M. R., Vrana, N. E., Ghaemmaghami, A. M., & Khademhosseini, A. (2017). Integrin-mediated interactions control macrophage polarization in 3D hydrogels. Advanced Healthcare Materials, 6(21), Article 1700289. https://doi.org/10.1002/adhm.201700289

Adverse immune reactions prevent clinical translation of numerous implantable devices and materials. Although inflammation is an essential part of tissue regeneration, chronic inflammation ultimately leads to implant failure. In particular, macrophag... Read More about Integrin-mediated interactions control macrophage polarization in 3D hydrogels.

Image based machine learning for identification of macrophage subsets (2017)
Journal Article
Rostam, H., Reynolds, P. M., Alexander, M. R., Gadegaard, N., & Ghaemmaghami, A. M. (2017). Image based machine learning for identification of macrophage subsets. Scientific Reports, 7(1), Article 3521. https://doi.org/10.1038/s41598-017-03780-z

Macrophages play a crucial rule in orchestrating immune responses against pathogens and foreign materials. Macrophages have remarkable plasticity in response to environmental cues and are able to acquire a spectrum of activation status, best exemplif... Read More about Image based machine learning for identification of macrophage subsets.

Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations (2017)
Journal Article
Dollinger, C., Ndreu-Halili, A., Uka, A., Singh, S., Sadam, H., Neuman, T., Rabineau, M., Lavalle, P., Dokmeci, M. R., Khademhosseini, A., Ghaemmaghami, A. M., & Vrana, N. E. (2017). Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations. Advanced Biosystems, 1(6), Article 1700041. https://doi.org/10.1002/adbi.201700041

Adverse immune reactions to implanted devices can seriously hamper the efficacy of implants. Monocyte derived macrophages play a crucial role in both initiation and resolution of the inflammatory response toward foreign bodies. As the surface microt... Read More about Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations.

Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage-laden gelatine hydrogels (2017)
Journal Article
Dollinger, C., Ciftci, S., Knopf-Marques, H., Ghaemmaghami, A. M., Debry, C., Barthes, J., & Vrana, N. E. (2018). Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage-laden gelatine hydrogels. Journal of Tissue Engineering and Regenerative Medicine, 12(2), 330-340. https://doi.org/10.1002/term.2458

The success of tissue engineering strategy is strongly related to the inflammatory response, mainly through the activity of macrophages that are key cells in initial immune response to implants. For engineered tissues, the presence of resident macrop... Read More about Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage-laden gelatine hydrogels.

Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states (2017)
Journal Article
Singh, S., Awuah, D., Rostam, H., Emes, R., Kandola, N. K., Onion, D., Htwe, S. S., Rajchagool, B., Cha, B.-H., Kim, D., Tighe, P., Vrana, N. E., Khademhosseini, A., & Ghaemmaghami, A. M. (in press). Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states. ACS Biomaterials Science and Engineering, https://doi.org/10.1021/acsbiomaterials.7b00104

Macrophages are master regulators of immune responses towards implanted biomaterials. The activation state adopted by macrophages in response to biomaterials determines their own phenotype and function as well as those of other resident and infiltrat... Read More about Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states.

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs (2017)
Journal Article
Salazar, F., Awuah, D., Negm, O. H., Shakib, F., & Ghaemmaghami, A. M. (2017). The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs. Scientific Reports, 7(1), Article 43337. https://doi.org/10.1038/srep43337

A controlled inflammatory response is required for protection against infection, but persistent inflammation causes tissue damage. Dendritic cells (DCs) have a unique capacity to promote both inflammatory and anti-inflammatory processes. One key mech... Read More about The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.

Role of ROCK isoforms in regulation of stiffness induced myofibroblast differentiation in lung fibrosis (2017)
Journal Article
Htwe, S. S., Cha, B. H., Yue, K., Khademhosseini, A., Knox, A. J., & Ghaemmaghami, A. M. (2017). Role of ROCK isoforms in regulation of stiffness induced myofibroblast differentiation in lung fibrosis. American Journal of Respiratory Cell and Molecular Biology, 56(6), 772-783. https://doi.org/10.1165/rcmb.2016-0306OC

Fibrosis is a major cause of progressive organ dysfunction in several chronic pulmonary diseases. Rho associated coiled-coil forming kinase (ROCK) has shown to be involved in myofibroblast differentiation driven by altered matrix stiffness in fibroti... Read More about Role of ROCK isoforms in regulation of stiffness induced myofibroblast differentiation in lung fibrosis.

Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation (2017)
Journal Article
Riabov, V., Salazar, F., Htwe, S. S., Gudima, A., Schmuttermaier, C., Barthes, J., Knopf-Marques, H., Klüter, H., Ghaemmaghami, A. M., Vrana, N. E., & Kzhyshkowska, J. (2017). Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation. Acta Biomaterialia, 53, 389-398. https://doi.org/10.1016/j.actbio.2017.01.071

The immediate tissue microenvironment of implanted biomedical devices and engineered tissues is highly influential on their long term fate and efficacy. The creation of a long-term anti-inflammatory microenvironment around implants and artificial tis... Read More about Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation.

Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures (2017)
Journal Article
Pokorny, M., Klemes, J., Zidek, O., Dollinger, C., Ozcebe, G., Singh, S., Veleby, V., Ghaemmaghami, A. M., Wolfova, L., & Vrana, N. E. (in press). Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures. Biomedical Physics and Engineering Express, 3(1), https://doi.org/10.1088/2057-1976/3/1/015002

Metallic implants are widely used in orthopaedic and orthodontic applications. However, generally surface treatment of the metallic surfaces is necessary to render them more biologically active. Herein, we describe a direct write printing method to m... Read More about Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures.