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Outputs (82)

Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0-11 year old children from 1998-2018 (2024)
Journal Article

Background There have been sharp increases in antidepressant and opioid prescriptions over the last 10 years, as well as increased over-the-counter medicine availability. However, the impact on childhood medicinal poisonings rates, particularly by s... Read More about Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0-11 year old children from 1998-2018.

Assessing the value of integrating national longitudinal shopping data into respiratory disease forecasting models (2023)
Journal Article

The COVID-19 pandemic led to unparalleled pressure on healthcare services. Improved healthcare planning in relation to diseases affecting the respiratory system has consequently become a key concern. We investigated the value of integrating sales of... Read More about Assessing the value of integrating national longitudinal shopping data into respiratory disease forecasting models.

Using Shopping Data to Improve the Diagnosis of Ovarian Cancer: Computational Analysis of a Web-Based Survey (2023)
Journal Article

Background Shopping data can be analysed using machine learning techniques to study population health. It is unknown if use of such methods can successfully investigate pre-diagnosis purchases linked to self-medication of symptoms of ovarian cance... Read More about Using Shopping Data to Improve the Diagnosis of Ovarian Cancer: Computational Analysis of a Web-Based Survey.

Using patient experiences to evaluate care and expectations in lung cancer: analysis of the English Cancer Patient Experience Survey linked with the national cancer registry (2022)
Journal Article

Purpose: Identification of unmet needs in person centred and supportive care could be limited by differences in experience across specific cancer populations. Using the experiences of people with lung cancer, we assess distinctions according to demog... Read More about Using patient experiences to evaluate care and expectations in lung cancer: analysis of the English Cancer Patient Experience Survey linked with the national cancer registry.

External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk (2021)
Journal Article

Introduction: Venous thromboembolism (VTE) is the leading cause of direct maternal mortality in high-income countries. We previously developed a risk prediction score for postpartum venous thromboembolism (VTE) in women without a previous VTE. In thi... Read More about External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk.

Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross-sectional study (2020)
Journal Article

Objective: This study tested the hypothesis that systemic inflammation is inversely associated with haemoglobin levels in adolescent girls in India. Methods: The study population consisted of adolescent girls aged between 10 and 19years living in a r... Read More about Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross-sectional study.

Do working practices of cancer nurse specialists improve clinical outcomes? Retrospective cohort analysis from the English National Lung Cancer Audit (2020)
Journal Article

Background Cancer nurse specialists are advanced practitioners who offer continuity of care and expert support for people diagnosed with specific cancers. Health Education England's Cancer Workforce Plan prioritises expansion of cancer nurse special... Read More about Do working practices of cancer nurse specialists improve clinical outcomes? Retrospective cohort analysis from the English National Lung Cancer Audit.

Weight, height and midupper arm circumference are associated with haemoglobin levels in adolescent girls living in rural India: A cross-sectional study (2019)
Journal Article

Objective: We aimed to explore the association of physical parameters with haemoglobin (Hb) levels to test the hypothesis that impaired physical development is associated with anaemia. Methods: A cross-sectional survey study recruited adolescent... Read More about Weight, height and midupper arm circumference are associated with haemoglobin levels in adolescent girls living in rural India: A cross-sectional study.

Is the English Cancer Patient Experience Survey representative? A comparative analysis with the National Lung Cancer Audit (2019)
Journal Article

© 2019 Elsevier B.V. Objectives: Healthcare systems increasingly recognise the importance of service users’ perspectives for improving care organisation and delivery. The English Cancer Patient Experience Survey (CPES) is carried out annually, howeve... Read More about Is the English Cancer Patient Experience Survey representative? A comparative analysis with the National Lung Cancer Audit.

Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article

Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More about Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age.

Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study (2019)
Journal Article

Objectives: To assess how nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) are managed and treated across primary and secondary care. Design: Population-based pregnancy cohort Setting: Medical records (CPRD-GOLD) from Englan... Read More about Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study.

Barriers to delivering advanced cancer nursing: a workload analysis of specialist nurse practice linked to the English National Lung Cancer Audit (2018)
Journal Article

Purpose: Health services across the world utilise advanced practice in cancer care. In the UK, lung cancer nurse specialists (LCNS) are recognised as key components of quality care in national guidelines, yet access to LCNS contact is unequal and som... Read More about Barriers to delivering advanced cancer nursing: a workload analysis of specialist nurse practice linked to the English National Lung Cancer Audit.

Are working practices of lung cancer nurse specialists associated with variation in peoples’ receipt of anticancer therapy? (2018)
Journal Article

Objectives Treatment choices for people with lung cancer may be influenced by contact and engagement with lung cancer nurse specialists (LCNSs). We investigated how service factors, LCNS workload, and LCNS working practices may influence the recei... Read More about Are working practices of lung cancer nurse specialists associated with variation in peoples’ receipt of anticancer therapy?.

Estimating the healthcare costs of children born to pregnant smokers in England: cohort study using primary and secondary healthcare data (2018)
Journal Article

Background and aims: Little is known about the long term economic consequences of smoking during pregnancy. We estimated the association between smoking in pregnancy and the costs of delivering healthcare to infants and children in England, and inves... Read More about Estimating the healthcare costs of children born to pregnant smokers in England: cohort study using primary and secondary healthcare data.

Stillbirth among women prescribed nicotine replacement therapy in pregnancy: analysis of a large UK pregnancy cohort (2018)
Journal Article

Objective: To compare risk of stillbirth between maternal smokers and those prescribed NRT during pregnancy. Design: Cross-sectional analysis nested in a pregnancy cohort with longitudinal routinely-recorded medical data. Setting: United Kingdo... Read More about Stillbirth among women prescribed nicotine replacement therapy in pregnancy: analysis of a large UK pregnancy cohort.

Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial (2017)
Journal Article

Regardless of geography or income, effective help for depression and anxiety only reaches a small proportion of those who might benefit from it. The scale of the problem suggests a role for effective, safe, anonymised public health driven online serv... Read More about Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial.

Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study (2017)
Journal Article

Background: Evidence for risks of adverse maternal and birth outcomes in women with hyperemesis gravidarum (HG) is predominantly from small studies, unknown, or conflicting. Methods: A population-based cohort study using secondary health care reco... Read More about Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study.

Risk factors for maternal anaemia and low birth weight in pregnant women living in rural India: a prospective cohort study (2017)
Journal Article

Objective: The aim of this prospective study was to estimate the prevalence and risk factors for maternal anaemia and low birth weight in pregnant women living in Maharashtra state, India. Study design: Prospective study Methods: Women between 3... Read More about Risk factors for maternal anaemia and low birth weight in pregnant women living in rural India: a prospective cohort study.

The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England (2017)
Journal Article

Background: Pregnant women may have an increased risk of stroke compared to non-pregnant women of similar age, but the magnitude and the timing of such risk are unclear. We examined the risk of first stroke event in women of childbearing age and comp... Read More about The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England.

Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England (2017)
Journal Article

Background: Maternal depression is common and associated with several child health outcomes. The impact on childhood injuries is underexplored, with existing studies relying on maternal reporting of injury occurrences. Using population healthcare dat... Read More about Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England.

Healthcare benefits linked with Below Poverty Line registration in India: Observations from Maharashtra Anaemia Study (MAS) (2017)
Journal Article

A 2015 Lancet paper by Patel et al. on healthcare access in India comprehensively discussed national health programmes where some benefits are linked with the country’s Below Poverty Line (BPL) registration scheme. BPL registration aims to support po... Read More about Healthcare benefits linked with Below Poverty Line registration in India: Observations from Maharashtra Anaemia Study (MAS).

Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study (2016)
Journal Article

Objective: To develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum). Design: Cohort study. Setting: Records from England based Clinical Practice Research Datalink (CPRD)... Read More about Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study.

Comparison of the NBM 200 non-invasive haemoglobin sensor with Sahli’s hemometer among adolescent girls in rural India (2016)
Journal Article

Objective: The study objective was to compare haemoglobin measurements between the NBM 200 (non-invasive haemoglobin sensor) and Sahli’s hemometer in adolescent girls in a rural Indian setting. Methods: Participants included girls aged between 13... Read More about Comparison of the NBM 200 non-invasive haemoglobin sensor with Sahli’s hemometer among adolescent girls in rural India.

Prevalence of iron deficiency anaemia and risk factors in 1,010 adolescent girls from rural Maharashtra, India: a cross-sectional survey (2016)
Journal Article

Objective: Iron deficiency anaemia (IDA) is the most common nutritional disorder observed in adolescent girls in India. Our aim was to investigate the prevalence and risk factors associated with IDA in rural Maharashtra, India to address current evid... Read More about Prevalence of iron deficiency anaemia and risk factors in 1,010 adolescent girls from rural Maharashtra, India: a cross-sectional survey.

Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England (2016)
Journal Article

Background: There is limited contemporary population based evidence on adverse birth outcomes and pregnancy related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variatio... Read More about Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England.

Child feeding and stunting prevalence in left-behind children: a descriptive analysis of data from a central and western Chinese population (2016)
Journal Article

Objectives: To examine the effect of parental rural-to-urban internal migration on nutritional status of left-behind children and how this is related to guardianship. Methods: We used UNICEF China’s maternal and child health survey data to investiga... Read More about Child feeding and stunting prevalence in left-behind children: a descriptive analysis of data from a central and western Chinese population.

Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England (2016)
Journal Article

Objective: To describe patterns in thermal injury incidence and hospitalisations by age, sex, calendar year and socioeconomic status among 0-4 year olds in England for the period 1998-2013. Participants: 708,050 children with linked primary care a... Read More about Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England.

Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data (2016)
Journal Article

Background: Understanding patterns of injury in England is challenging due to a lack of national injury surveillance data. Through recent linkage of a large primary care research database to hospitalization and mortality data, we describe the epide... Read More about Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data.

Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies (2016)
Journal Article

STUDY QUESTION: What are the maternal risk factors for hyperemesis gravidarum (HG) hospital admission, readmission and reoccurrence in a following pregnancy? SUMMARY ANSWER: Young age, less socioeconomic deprivation, nulliparity, Asian or Black ethn... Read More about Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies.

Changes in poisonings among adolescents in the UK between 1992 and 2012: a population based cohort study (2016)
Journal Article

Background: Poisonings are a common cause of morbidity and mortality among adolescents. Yet surveillance data indicating current incidence rates (IRs) and time trends are lacking, making policy development and service planning difficult. We utilised... Read More about Changes in poisonings among adolescents in the UK between 1992 and 2012: a population based cohort study.

The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study (2016)
Journal Article

Background: Patients with coeliac disease are considered as individuals for whom pneumococcal vaccination is advocated. Aim: To quantify the risk of community-acquired pneumonia among patients with coeliac disease, assessing whether vaccination ag... Read More about The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study.

Which patients are assessed by lung cancer nurse specialists? A national lung cancer audit study of over 128,000 patients across England (2016)
Journal Article

Background: Lung cancer nurse specialists (LCNS) are integral to the multidisciplinary clinical team, providing personalised physical and psycho-social interventions, and care management for people with lung cancer. The National Institute of Health a... Read More about Which patients are assessed by lung cancer nurse specialists? A national lung cancer audit study of over 128,000 patients across England.

Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study (2015)
Journal Article

Objective: To accurately define venous thromboembolism (VTE) in the routinely collected Swedish health registers and quantify its incidence in and around pregnancy. Study design: Cohort study using data from the Swedish Medical Birth Registry (MBR)... Read More about Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study.

Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study (2015)
Journal Article

Background: Clinical studies have reported reduced fertility in women with inflammatory bowel disease (IBD). Aim: To compare fertility rates in women with IBD to those in women without IBD and assess whether the relative fertility differed followi... Read More about Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study.

Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis (2015)
Journal Article

INTRODUCTION: Quantifying excess cause-specific mortality among people with coeliac disease (CD) compared with the general population accounting for competing risks will allow accurate information to be given on risk of death from specific causes.... Read More about Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis.

Congenital anomalies in children of mothers taking antiepileptic drugs with and without periconceptional high dose folic acid use: a population-based cohort study (2015)
Journal Article

BACKGROUND: Antenatal antiepileptic drug (AED) use has been found to be associated with increased major congenital anomaly (CA) risks. However whether such AED-associated risks were different according to periconceptional high dose (5mg daily) folic... Read More about Congenital anomalies in children of mothers taking antiepileptic drugs with and without periconceptional high dose folic acid use: a population-based cohort study.

Identification of incident poisoning, fracture and burn events using linked primary care, secondary care, and mortality data from England: implications for research and surveillance (2015)
Journal Article

Background: English national injury data collection systems are restricted to hospitalisations and deaths. With recent linkage of a large primary care database, the Clinical Practice Research Datalink (CPRD), with secondary care and mortality data we... Read More about Identification of incident poisoning, fracture and burn events using linked primary care, secondary care, and mortality data from England: implications for research and surveillance.

Is there an association between the coverage of immunisation boosters by the age of 5 and deprivation? An ecological study (2015)
Journal Article

Objective: To determine whether there was an association between the coverage of booster immunisation of Diphtheria, Tetanus, acellular Pertussis and Polio (DTaP/IPV) and second Measles, Mumps and Rubella (MMR) dose by age 5 in accordance with the En... Read More about Is there an association between the coverage of immunisation boosters by the age of 5 and deprivation? An ecological study.

Persistence of health inequalities in childhood injury in the UK: a population-based cohort study of children under 5 (2014)
Journal Article

BACKGROUND: Injury is a significant cause of childhood death and can result in substantial long-term disability. Injuries are more common in children from socio-economically deprived families, contributing to health inequalities between the most and... Read More about Persistence of health inequalities in childhood injury in the UK: a population-based cohort study of children under 5.

A comparison of UK primary care data with other national data sources for monitoring the prevalence of smoking during pregnancy (2014)
Journal Article

Background: We aimed to assess the potential usefulness of primary care data for estimating smoking prevalence in pregnancy by comparing the primary care data estimates with those obtained from other data sources. Methods: In The Health Improvement... Read More about A comparison of UK primary care data with other national data sources for monitoring the prevalence of smoking during pregnancy.

Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study (2014)
Journal Article

Objective: To examine major congenital anomaly (CA) risks in children of mothers with coeliac disease (CD) compared with mothers without CD. Design: Population-based cohort study. Setting: Linked maternal–child medical records from a large pr... Read More about Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study.

Prescribing of nicotine replacement therapy in and around pregnancy: a population-based study using primary care data (2014)
Journal Article

Background Licensing arrangements for nicotine replacement therapy (NRT) in the UK were broadened in 2005 to allow prescribing to pregnant smokers. However, estimates of NRT prescribing in pregnant females in the UK are currently lacking. Aim To... Read More about Prescribing of nicotine replacement therapy in and around pregnancy: a population-based study using primary care data.

Impact of risk factors on the timing of first postpartum venous thromboembolism: a population-based cohort study from England (2014)
Journal Article

For women with preeclampsia, BMI >30 kg/m2, infection, or those having cesarean delivery, VTE risk remained elevated for 6 weeks postpartum.For women with postpartum hemorrhage or preterm birth, the relative rate of VTE was only increased for the... Read More about Impact of risk factors on the timing of first postpartum venous thromboembolism: a population-based cohort study from England.

Women with celiac disease present with fertility problems no more often than women in the general population (2014)
Journal Article

BACKGROUND & AIMS: Studies have associated infertility with celiac disease. However, these included small numbers of women attending infertility specialist services and subsequently screened for celiac disease, and therefore may not have been represe... Read More about Women with celiac disease present with fertility problems no more often than women in the general population.

Pregnancy complications and adverse birth outcomes among women with celiac disease: a population-based study from England (2014)
Journal Article

OBJECTIVES: Evidence-based information about adverse birth outcomes and pregnancy complications is crucial when counseling women with celiac disease (CD); however, limited population-based data on such risks exist. We estimated these for pregnant wom... Read More about Pregnancy complications and adverse birth outcomes among women with celiac disease: a population-based study from England.

First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study (2014)
Journal Article

BACKGROUND: Despite their widespread use the effects of taking benzodiazepines and non-benzodiazepine hypnotics during pregnancy on the risk of major congenital anomaly (MCA) are uncertain. The objectives were to estimate absolute and relative risks... Read More about First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study.

Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study (2014)
Journal Article

OBJECTIVES: Few studies have quantified the incidence and prevalence of celiac disease (CD) and dermatitis herpetiformis (DH) nationally and regionally by time and age groups. Understanding this epidemiology is crucial for hypothesizing about causes... Read More about Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study.

Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study (2014)
Journal Article

OBJECTIVE: To estimate risks of major congenital anomaly (MCA) among children of mothers prescribed antidepressants during early pregnancy or diagnosed with depression but without antidepressant prescriptions. DESIGN: Population-based cohort study.... Read More about Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study.

Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit (2014)
Journal Article

Background The purpose of this study was to identify trends in survival and chemotherapy use for individuals with small-cell lung cancer (SCLC) in England using the National Lung Cancer Audit (NLCA). Methods We used data from the NLCA database... Read More about Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit.

How to read a cohort study (2014)
Book Chapter

The cohort is the basis of all epidemiologic study designs as it is the closest way to study the natural progression of people's life course over which the temporal relationship between exposures and outcomes can be assessed. Although a cohort is def... Read More about How to read a cohort study.

The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation (2014)
Journal Article

We described the health resource utilisation (HRU) and associated direct medical costs of managing epilepsy in children and young people (CYP) using population-level data from the United Kingdom. The study cohort were CYP born between 1988 and 20... Read More about The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation.

Risk of first venous thromboembolism in pregnant women in hospital: population based cohort study from England (2013)
Journal Article

Objective: To examine the potential for preventing venous thromboembolism during and after antepartum hospital admissions in pregnant women. Design: Cohort study using linked primary (Clinical Practice Research Datalink) and secondary (Hospital E... Read More about Risk of first venous thromboembolism in pregnant women in hospital: population based cohort study from England.

Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data (2013)
Journal Article

Scald injury is common, accounting for half of all burns in pre-school children. Most scalds are preventable and health professionals can play an important role in targeting interventions to those at greatest risk. However, the potential for routinel... Read More about Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data.

Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications (2013)
Journal Article

Background & aims: Concerns persist about the risk of major congenital anomalies in children of women with inflammatory bowel disease (IBD), and whether medication use affects risk. We assessed these risks, and variations in use of medications by wom... Read More about Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications.

Completeness of maternal smoking status recording during pregnancy in United Kingdom primary care data (2013)
Journal Article

Background: Given the health impacts of smoking during pregnancy and the opportunity for primary healthcare teams to encourage pregnant smokers to quit, we assessed the completeness of gestational smoking status recording in primary care data and inv... Read More about Completeness of maternal smoking status recording during pregnancy in United Kingdom primary care data.

The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis (2013)
Journal Article

Background: Recent linkage between primary and secondary care data has provided valuable information for studying heath outcomes that may initially present in different health care settings. The aim of this study was therefore, twofold: to use linke... Read More about The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis.

Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data (2012)
Journal Article

Background: Injuries in childhood are largely preventable yet an estimated 2,400 children die every day because of injury and violence. Despite this, the factors that contribute to injury occurrence have not been quantified at the population scale us... Read More about Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data.