Outputs (115)

Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK (2024)
Journal Article
Khan, K., Hall, C. L., Babbage, C., Dodzo, S., Greenhalgh, C., Lucassen, M., …Hollis, C. (2024). Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK. Pilot and Feasibility Studies, 10(1), Article 53. https://doi.org/10.1186/s40814-024-01475-7

Background : A serious game called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), originally developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depressi... Read More about Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK.

Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-month Follow-Up of a Randomized Clinical Trial (2024)
Journal Article
Andrén, P., Sampaio, F., Ringberg, H., Wachtmeister, V., Warnström, M., Isomura, K., …Mataix-Cols, D. (in press). Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-month Follow-Up of a Randomized Clinical Trial. JAMA Network Open,

Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial (2024)
Journal Article
Williams, A. J., Cleare, S., Borschmann, R., Tench, C. R., Gross, J., Hollis, C., …Slovak, P. (2024). Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial. BMJ Open, 14(1), Article e079801. https://doi.org/10.1136/bmjopen-2023-079801

Introduction: Purrble, a socially assistive robot, was codesigned with children to support in situ emotion regulation. Preliminary evidence has found that LGBTQ+ youth are receptive to Purrble and find it to be an acceptable intervention to assist wi... Read More about Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial.

Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies (2023)
Journal Article
Williams, A. J., Townsend, E., Naeche, N., Chapman-Nisar, A., Hollis, C., & Slovak, P. (2023). Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies. JMIR Formative Research, 7(1), Article e52336. https://doi.org/10.2196/52336

Background: Minority youth are at an increased risk of experiencing self-harmful thoughts and behaviors. However, there is limited evidence of successful interventions to support young people in the moment of their distress. Digital interventions are... Read More about Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies.

Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data (2023)
Journal Article
Jack, R. H., Joseph, R. M., Hollis, C., Hippisley-Cox, J., Butler, D., Waldram, D., & Coupland, C. (2023). Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data. BMJ Mental Health, 26(1), Article e300855. https://doi.org/10.1136/bmjment-2023-300855

Background There is an increasing demand for mental health services for young people, which may vary across the year. Objective To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in... Read More about Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.

Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation (2023)
Journal Article
Hollis, C., Hall, C. L., Khan, K., Le Novere, M., Marston, L., Jones, R., …Murphy, T. (2023). Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation. Health Technology Assessment, 27(18), 1-120. https://doi.org/10.3310/cpms3211

Background: Behavioural therapy for tics is difficult to access, and little is known about its effectiveness when delivered online. Objective: To investigate the clinical and cost-effectiveness of an online-delivered, therapist and parent-... Read More about Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation.

Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of ADHD: a systematic review and meta-analysis (2023)
Journal Article
Bellato, A., Hall, C. L., Groom, M. J., Simonoff, E., Thapar, A., Hollis, C., & Cortese, S. (2023). Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of ADHD: a systematic review and meta-analysis. Journal of Child Psychology and Psychiatry, https://doi.org/10.1111/jcpp.13901

Background Several computerised cognitive tests (e.g. continuous performance test) have been developed to support the clinical assessment of attention-deficit/hyperactivity disorder (ADHD). Here, we appraised the evidence-base underpinning the use o... Read More about Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of ADHD: a systematic review and meta-analysis.

Importance of accurate and accessible recording of healthcare contacts in mental health (2023)
Journal Article
Jack, R. H., Coupland, C. A., Joseph, R. M., Hollis, C., Morriss, R., Knaggs, R. D., …Hippisley-Cox, J. (2023). Importance of accurate and accessible recording of healthcare contacts in mental health. BMC Medicine, 21, Article 346. https://doi.org/10.1186/s12916-023-03044-w

The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know? (2023)
Journal Article
Hall, C. L., Bellato, A., Kirk, J. D., & Hollis, C. (2023). The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?. Paediatrics and Child Health, 33(9), 259-264. https://doi.org/10.1016/j.paed.2023.06.006

The assessment of Attention-Deficit/Hyperactivity Disorder (ADHD) typically relies on subjective observer reports from parents, teachers, or the young person, combined with clinical observation and history. Children and young people often experience... Read More about The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?.

Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism (2023)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Ropar, D., Hollis, C., & Groom, M. J. (2023). Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism. Cortex, 166, 306-321. https://doi.org/10.1016/j.cortex.2023.06.002

Introduction Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) may be characterized by different profiles of visual attention orienting. However, there are also many inconsistent findings emerging from the literature... Read More about Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism.

Remote administration of ADHD-sensitive cognitive tasks: a pilot study (2023)
Journal Article
Sun, S., Denyer, H., Sankesara, H., Deng, Q., Ranjan, Y., Conde, P., …Kuntsi, J. (2023). Remote administration of ADHD-sensitive cognitive tasks: a pilot study. Journal of Attention Disorders, 27(9), 1040-1050. https://doi.org/10.1177/10870547231172

Objective: We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous... Read More about Remote administration of ADHD-sensitive cognitive tasks: a pilot study.

We need timely access to mental health data: implications of the Goldacre review (2023)
Journal Article
Astle, D. E., Moore, A., Marryat, L., Viding, E., Mansfield, K. L., Fazel, M., …Ford, T. J. (2023). We need timely access to mental health data: implications of the Goldacre review. Lancet Psychiatry, 10(4), 242-244. https://doi.org/10.1016/S2215-0366%2823%2900030-5

The Goldacre review, published in April, 2022, 1 is a landmark evaluation of the use, availability, and safety of National Health Service (NHS) data across all four nations of the UK. The review underscores the necessary role of data in driving healt... Read More about We need timely access to mental health data: implications of the Goldacre review.

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study (2023)
Journal Article
Andrews, J. A., Craven, M. P., Guo, B., Weyer, J., Lees, S., Zormpas, S. I., …RADAR-CNS Consortium. (2023). Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study. JMIR Neurotechnology, 2, Article e41439. https://doi.org/10.2196/41439

Background: Multiple sclerosis (MS), epilepsy, and depression are chronic central nervous system conditions in which remote measurement technology (RMT) may offer benefits compared with usual assessment. We previously worked with clinicians, patients... Read More about Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study.

How are adverse events identified and categorised in trials of digital mental health interventions? A narrative scoping review of trials in the ISRCTN registry (2023)
Journal Article
Bergin, A. D. G., Valentine, A. Z., Rennick Egglestone, S., Slade, M., Hollis, C., & Hall, C. L. (2023). How are adverse events identified and categorised in trials of digital mental health interventions? A narrative scoping review of trials in the ISRCTN registry. JMIR Mental Health, 10, Article e42501. https://doi.org/10.2196/42501

Background: To contextualize the benefits of an intervention, it is important that adverse events (AEs) are reported. This is potentially difficult in trials of digital mental health interventions, where delivery may be remote and the mechanisms of a... Read More about How are adverse events identified and categorised in trials of digital mental health interventions? A narrative scoping review of trials in the ISRCTN registry.

Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study (2023)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C. A., Hall, C. L., & Hollis, C. (2023). Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study. eClinicalMedicine, 57, Article 101857. https://doi.org/10.1016/j.eclinm.2023.101857

Background: Since the onset of the coronavirus (COVID-19) pandemic, clinicians have reported an increase in presentations of sudden and new onset tics particularly affecting teenage girls. This population-based study aimed to describe and compare the... Read More about Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study.

Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial (2023)
Journal Article
Hollis, C., Hall, C. L., Khan, K., Jones, R., Marston, L., Le Novere, M., …Murphy, T. (2023). Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial. Journal of Child Psychology and Psychiatry, 64(6), 941-951. https://doi.org/10.1111/jcpp.13756

Background: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 a... Read More about Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial.

Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial (2022)
Journal Article
Andrén, P., Holmsved, M., Ringberg, H., Wachtmeister, V., Isomura, K., Aspvall, K., …Mataix-Cols, D. (2022). Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial. JAMA Network Open, 5(8), Article e2225614. https://doi.org/10.1001/jamanetworkopen.2022.25614

Importance: The availability of behavior therapy for individuals with Tourette syndrome (TS) and chronic tic disorder (CTD) is limited. Objective: To determine the efficacy and cost-effectiveness of internet-delivered exposure and response prevention... Read More about Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial.

Digital and remote behavioral therapies for treating tic disorders: Recent advances and next steps (2022)
Journal Article
Khan, K., Hollis, C., Murphy, T., & Hall, C. L. (2022). Digital and remote behavioral therapies for treating tic disorders: Recent advances and next steps. Frontiers in Psychiatry, 13, Article 928487. https://doi.org/10.3389/fpsyt.2022.928487

Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals (2022)
Journal Article
Andrews, J. A., Craven, M. P., Lang, A. R., Guo, B., Morriss, R., Hollis, C., & RADAR-CNS Consortium. (2022). Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals. BMC Medical Informatics and Decision Making, 22(1), Article 125. https://doi.org/10.1186/s12911-022-01856-z

BACKGROUND: Epilepsy, multiple sclerosis(MS) and depression are long term, central nervous system disorders which have a significant impact on everyday life. Evaluating symptoms of these conditions is problematic and typically involves repeated visit... Read More about Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals.

The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study (2022)
Journal Article
Hall, C. L., Marston, L., Khan, K., Brown, B. J., Sanderson, C., Andrén, P., …Murphy, T. (2022). The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study. Child Psychiatry and Human Development, 54, 1499–1509. https://doi.org/10.1007/s10578-022-01348-1

To understand how children and young people with tic disorders were affected by COVID-19, we compared pre and during pandemic scores on the Yale Global Tic Severity Scale (YGTSS). Participants were young people (N = 112; male:78%; 9–17 years) randomi... Read More about The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study.

Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses (2022)
Journal Article
Freeman, D., Lambe, S., Kabir, T., Petit, A., Rosebrock, L., Yu, L., …West, J. (2022). Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses. Lancet Psychiatry, 9(5), 375-388. https://doi.org/10.1016/s2215-0366%2822%2900060-8

Background Automated delivery of psychological therapy using immersive technologies such as virtual reality (VR) might greatly increase the availability of effective help for patients. We aimed to evaluate the efficacy of an automated VR cognitive t... Read More about Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses.

Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial (2022)
Journal Article
Khan, K., Hollis, C., Hall, C. L., Davies, E. B., Murray, E., Andrén, P., …Glazebrook, C. (2022). Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial. Journal of Behavioral and Cognitive Therapy, 32(3), 197-206. https://doi.org/10.1016/j.jbct.2022.02.005

The Online Remote Behavioural Intervention for Tics (ORBIT) trial found that an internet-delivered, therapist-supported, and parent-assisted Exposure and Response Prevention (ERP) intervention reduced tic severity and improved clinical outcomes. This... Read More about Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

Treatment adherence might be the key to online Exposure and Response Prevention for paediatric tics – Authors' reply (2022)
Journal Article
Hollis, C., Hall, C. L., Marston, L., & ORBIT Trial Team. (2022). Treatment adherence might be the key to online Exposure and Response Prevention for paediatric tics – Authors' reply. Lancet Psychiatry, 9(2), 106-107. https://doi.org/10.1016/S2215-0366%2821%2900503-4

We thank Qianzhi Wang and colleagues for their endorsement of the ORBIT trial1, 2 and for acknowledging the importance of the findings. We are grateful for the opportunity to clarify the issue of adherence within the trial, which we believe to be a... Read More about Treatment adherence might be the key to online Exposure and Response Prevention for paediatric tics – Authors' reply.

Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions (2021)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Ropar, D., Hollis, C., & Groom, M. J. (2022). Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions. Journal of Autism and Developmental Disorders, 52, 4679-4691. https://doi.org/10.1007/s10803-021-05244-w

Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents... Read More about Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions.

The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey (2021)
Journal Article
Andrews, J. A., Craven, M. P., Lang, A. R., Guo, B., Morriss, R., Hollis, C., & The RADAR-CNS Consortium. (2021). The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey. BMC Medical Informatics and Decision Making, 21, Article 282. https://doi.org/10.1186/s12911-021-01640-5

Background: A variety of smartphone apps and wearables are available both to help patients monitor their health and to support health care professionals (HCPs) in providing clinical care. As part of the RADAR-CNS consortium, we have conducted researc... Read More about The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey.

Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial (2021)
Journal Article
Andrén, P., Fernández De La Cruz, L., Isomura, K., Lenhard, F., Hall, C. L., Davies, E. B., …Mataix-Cols, D. (2021). Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial. Trials, 22, Article 669. https://doi.org/10.1186/s13063-021-05592-z

Background Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to... Read More about Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial.

Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial (2021)
Journal Article
Andrén, P., de la Cruz, L. F., Isomura, K., Lenhard, F., Hall, C. L., Davies, E. B., …Mataix-Cols, D. (2021). Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial. Trials, 22, Article 669. https://doi.org/10.1186/s13063-021-05592-z

Background: Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to... Read More about Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial.

Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial (2021)
Journal Article
Hollis, C., Hall, C. L., Jones, R., Marston, L., Novere, M. L., Hunter, R., …Murray, E. (2021). Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial. Lancet Psychiatry, 8(10), 871-882. https://doi.org/10.1016/S2215-0366%2821%2900235-2

Background: Exposure and Response Prevention (ERP) is a form of behavioural therapy for tics; however, its effectiveness remains uncertain. We aimed to evaluate the effectiveness of internet-delivered, therapist-supported, and parent-assisted ERP for... Read More about Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial.

Fidelity of Delivery and Contextual Factors Influencing Children’s Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial (2021)
Journal Article
Khan, K., Hollis, C., Hall, C. L., Murray, E., Davies, E. B., Andrén, P., …Glazebrook, C. (2021). Fidelity of Delivery and Contextual Factors Influencing Children’s Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial. Journal of Medical Internet Research, 23(6), Article e25470. https://doi.org/10.2196/25470

Background: The Online Remote Behavioral Intervention for Tics (ORBIT) study was a multicenter randomized controlled trial of a complex intervention that consisted of a web-based behavioral intervention for children and young people with tic disorder... Read More about Fidelity of Delivery and Contextual Factors Influencing Children’s Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial.

Fidelity of delivery and contextual factors influencing children’s level of engagement: Process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) Trial (2021)
Journal Article
Khan, K., Hollis, C., Hall, C., Murray, E., Davies, E., Andrén, P., …Glazebrook, C. (2021). Fidelity of delivery and contextual factors influencing children’s level of engagement: Process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) Trial. Journal of Medical Internet Research, 23(6), Article e25470. https://doi.org/10.2196/25470

Background: The Online Remote Behavioral Intervention for Tics (ORBIT) study was a multicenter randomized controlled trial of a complex intervention that consisted of a web-based behavioral intervention for children and young people with tic disorde... Read More about Fidelity of delivery and contextual factors influencing children’s level of engagement: Process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) Trial.

Correction to: Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial (2021)
Journal Article
Williams, L., Hall, C. L., Brown, S., Guo, B., James, M., Franceschini, M., …Groom, M. J. (2021). Correction to: Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial. Pilot and Feasibility Studies, 7, Article 94. https://doi.org/10.1186/s40814-021-00830-2

What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? (2021)
Journal Article
Arora, I., Bellato, A., Gliga, T., Ropar, D., Kochhar, P., Hollis, C., & Groom, M. (2022). What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism?. Journal of Autism and Developmental Disorders, 52(2), 600–616. https://doi.org/10.1007/s10803-021-04961-6

Slower habituation to repeating stimuli characterises Autism, but it is not known whether this is driven by difficulties with information processing or an attentional bias towards sameness. We conducted eye-tracking and presented looming geometrical... Read More about What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism?.

Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial (2021)
Journal Article
Williams, L., Hall, C. L., Brown, S., Guo, B., James, M., Franceschini, M., …Groom, M. J. (2021). Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial. Pilot and Feasibility Studies, 7, Article 68. https://doi.org/10.1186/s40814-021-00788-1

Background Medication for attention deficit hyperactivity disorder (ADHD) should be closely monitored to ensure optimisation. There is growing interest in using computerised assessments of ADHD symptoms to support medication monitoring. The aim of t... Read More about Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial.

Is autonomic function during resting-state atypical in Autism: A systematic review of evidence (2021)
Journal Article
Arora, I., Bellato, A., Ropar, D., Hollis, C., & Groom, M. (2021). Is autonomic function during resting-state atypical in Autism: A systematic review of evidence. Neuroscience and Biobehavioral Reviews, 125, 417-441. https://doi.org/10.1016/j.neubiorev.2021.02.041

Background: Theories of differences in resting-state arousal in autistic individuals are influential. Differences in arousal during resting-state would impact engagement and adaptation to the environment, having a cascading effect on development of a... Read More about Is autonomic function during resting-state atypical in Autism: A systematic review of evidence.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder (2021)
Journal Article
Faraone, S. V., Banaschewski, T., Coghill, D., Zheng, Y., Biederman, J., Bellgrove, M. A., …Wang, Y. (2021). The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder. Neuroscience and Biobehavioral Reviews, 128, 789-818. https://doi.org/10.1016/j.neubiorev.2021.01.022

Background Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. Methods We reviewed studies with more than... Read More about The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.

The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review (2021)
Journal Article
Valentine, A. Z., Hall, S. S., Young, E., Brown, B. J., Groom, M. J., Hollis, C., & Hall, C. L. (2021). The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review. Journal of Medical Internet Research, 23(1), Article e22619. https://doi.org/10.2196/22619

Background: In response to COVID-19 there is increasing momentum behind the development and delivery of telehealth. To assess the anticipated exponential growth in telehealth it is important we accurately capture how telehealth was used in specific f... Read More about The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review.

Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people (2020)
Journal Article
Hall, C. L., Sanderson, C., Brown, B. J., Andrén, P., Bennett, S., Chamberlain, L. R., …Murray, E. (2020). Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people. Trials, 21(1), Article 1011. https://doi.org/10.1186/s13063-020-04902-1

Background: Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention. These issues may be exacerbated when recruiting vulnerable... Read More about Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people.

The transition from children’s services to adult services for young people with attention deficit hyperactivity disorder: the CATCh-uS mixed-methods study (2020)
Journal Article
Janssens, A., Eke, H., Price, A., Newlove-Delgado, T., Blake, S., Ani, C., …Ford, T. (2020). The transition from children’s services to adult services for young people with attention deficit hyperactivity disorder: the CATCh-uS mixed-methods study. Health Services and Delivery Research, 8(42), 1-154. https://doi.org/10.3310/hsdr08420

Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study (2020)
Journal Article
Craven, M. P., Andrews, J., Lang, A. R., Simblett, S. K., Bruce, S., Thorpe, S., …The RADAR-CNS Consortium. (2020). Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study. JMIR Formative Research, 4(11), Article e22756. https://doi.org/10.2196/22756

Background: Epilepsy, multiple sclerosis (MS), and depression are chronic conditions where technology holds potential in clinical monitoring and self-management. Over 5 years, the Remote Assessment of Disease and Relapse-Central Nervous System (RADAR... Read More about Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study.

Therapist supported online interventions for children and young people with tic disorders: lessons learned from a randomized controlled trial and considerations for future practice (2020)
Journal Article
Chamberlain, L. R., Hall, C., Andrén, P., Davies, E. B., Kilgariff, J., Kouzoupi, N., …Hollis, C. (2020). Therapist supported online interventions for children and young people with tic disorders: lessons learned from a randomized controlled trial and considerations for future practice. JMIR Mental Health, 7(10), Article e19600. https://doi.org/10.2196/19600

Preventive digital mental health interventions for children and young people: a review of the design and reporting of research (2020)
Journal Article
Bergin, A. D., Vallejos, E. P., Davies, E. B., Daley, D., Ford, T., Harold, G., …Hollis, C. (2020). Preventive digital mental health interventions for children and young people: a review of the design and reporting of research. npj Digital Medicine, 3(1), Article 133. https://doi.org/10.1038/s41746-020-00339-7

Digital health interventions (DHIs) have frequently been highlighted as one way to respond to increasing levels of mental health problems in children and young people. Whilst many are developed to address existing mental health problems, there is als... Read More about Preventive digital mental health interventions for children and young people: a review of the design and reporting of research.

Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study (2020)
Journal Article
Andrews, J. A., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., Hollis, C., & The RADAR-CNS Consortium. (2020). Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study. Journal of Medical Internet Research, 22(7), Article e17414. https://doi.org/10.2196/17414

Background: Remote measurement technologies (RMT) can be used to collect data on a variety of bio-behavioral variables, which may improve the care of patients with central nervous system disorders. Although various studies have explored their potenti... Read More about Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study.

Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study (2020)
Journal Article
Morrison, A. P., Pyle, M., Maughan, D., Johns, L., Freeman, D., Broome, M. R., …James, A. (2020). Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study. Lancet Psychiatry, 7(9), 788-800. https://doi.org/10.1016/S2215-0366%2820%2930248-0

Background: Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK National Institute for Health and... Read More about Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Butler, D., …Hippisley-Cox, J. (2020). Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study. PLoS Medicine, 17(7), Article e1003215. https://doi.org/10.1371/journal.pmed.1003215

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

A systematic review evaluating the implementation of technologies to assess, monitor and treat neurodevelopmental disorders: A map of the current evidence (2020)
Journal Article
Valentine, A. Z., Brown, B. J., Groom, M. J., Young, E., Hollis, C., & Hall, C. L. (2020). A systematic review evaluating the implementation of technologies to assess, monitor and treat neurodevelopmental disorders: A map of the current evidence. Clinical Psychology Review, 80, 101870. https://doi.org/10.1016/j.cpr.2020.101870

Technology-based interventions provide an attractive option for improving service provision for neurodevelopmental disorders (NDD), for example, widening access to interventions, objective assessment, and monitoring; however, it is unclear whether th... Read More about A systematic review evaluating the implementation of technologies to assess, monitor and treat neurodevelopmental disorders: A map of the current evidence.

Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism (2020)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Hollis, C., & Groom, M. J. (2020). Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism. Brain Sciences, 10(5), 1-12. https://doi.org/10.3390/brainsci10050272

Investigating electrophysiological measures during resting-state might be useful to investigate brain functioning and responsivity in individuals under diagnostic assessment for attention deficit hyperactivity disorder (ADHD) and autism. EEG was reco... Read More about Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism.

Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database (2020)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C., Butler, D., Hollis, C., Morriss, R., …Hippisley-Cox, J. (2020). Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database. BMC Medicine, 18(1), https://doi.org/10.1186/s12916-020-01560-7

© 2020 The Author(s). Background: Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in children an... Read More about Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database.

Protocol for the Process Evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) randomized controlled trial for children and young people (2020)
Journal Article
Khan, K., Hollis, C., Hall, C. L., Davies, E. B., Mataix-Cols, D., Andrén, P., …Glazebrook, C. (2020). Protocol for the Process Evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) randomized controlled trial for children and young people. Trials, 21(1), Article 6. https://doi.org/10.1186/s13063-019-3974-3

Background Process evaluations are an important component in the interpretation and understanding of outcomes in trials. The Online Remote Behavioural Intervention for Tics (ORBIT) study is a randomized controlled trial evaluating the effectivenes... Read More about Protocol for the Process Evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) randomized controlled trial for children and young people.

Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint) (2019)
Other
Andrews, J., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., & Hollis, C. (in press). Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint)

Background: Remote measurement technologies (RMTs) can be used to collect data on a variety of bio-behavioural variables, which may benefit the care of people with central nervous system disorders. While various studies have explored their potential... Read More about Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint).

Is autonomic nervous system function atypical in attention deficit hyperactivity disorder (ADHD)? A systematic review of the evidence (2019)
Journal Article
Bellato, A., Arora, I., Hollis, C., & Groom, M. J. (2020). Is autonomic nervous system function atypical in attention deficit hyperactivity disorder (ADHD)? A systematic review of the evidence. Neuroscience and Biobehavioral Reviews, 108, 182-206. https://doi.org/10.1016/j.neubiorev.2019.11.001

Although arousal mechanisms have frequently been found to be atypical in ADHD, these findings usually emerged from indirect behavioural measures which give only a limited understanding of arousal dysregulation in this condition. To assess the hypothe... Read More about Is autonomic nervous system function atypical in attention deficit hyperactivity disorder (ADHD)? A systematic review of the evidence.

The Effectiveness of Web-Based Interventions Delivered to Children and Young People With Neurodevelopmental Disorders: Systematic Review and Meta-Analysis (2019)
Journal Article
Khan, K., Hall, C. L., Davies, E. B., Hollis, C., & Glazebrook, C. (2019). The Effectiveness of Web-Based Interventions Delivered to Children and Young People With Neurodevelopmental Disorders: Systematic Review and Meta-Analysis. Journal of Medical Internet Research, 21(11), Article e13478. https://doi.org/10.2196/13478

Background: The prevalence of certain neurodevelopmental disorders, specifically autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), has been increasing over the last four decades. Nonpharmacological interventions are... Read More about The Effectiveness of Web-Based Interventions Delivered to Children and Young People With Neurodevelopmental Disorders: Systematic Review and Meta-Analysis.

Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence (2019)
Journal Article
Krinzinger, H., Hall, C. L., Groom, M. J., Ansari, M. T., Banaschewski, T., Buitelaar, J. K., …Liddle, E. B. (2019). Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence. Neuroscience and Biobehavioral Reviews, 107, 945-968. https://doi.org/10.1016/j.neubiorev.2019.09.023

Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns abo... Read More about Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence.

Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange) (2019)
Journal Article
Freeman, D., Yu, L., Kabir, T., Martin, J., Craven, M., Leal, J., …Waite, F. (2019). Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange). BMJ Open, 9(8), e031606. https://doi.org/10.1136/bmjopen-2019-031606

Introduction Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead patients to withdraw from a... Read More about Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange).

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

The validity of the Strengths and Difficulties Questionnaire (SDQ) for children with ADHD symptoms (2019)
Journal Article
Hall, C. L., Guo, B., Valentine, A. Z., Groom, M. J., Daley, D., Sayal, K., & Hollis, C. (2019). The validity of the Strengths and Difficulties Questionnaire (SDQ) for children with ADHD symptoms. PLoS ONE, 14(6), Article e0218518. https://doi.org/10.1371/journal.pone.0218518

Background: The Strengths and Difficulties Questionnaire (SDQ) is widely used to assess child and adolescent mental health problems. However, the factor structure of the SDQ is subject to debate and there is limited evidence investigating measurement... Read More about The validity of the Strengths and Difficulties Questionnaire (SDQ) for children with ADHD symptoms.

Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders (2019)
Journal Article
Hall, C. L., Brown, S., James, M., Martin, J. L., Brown, N., Selby, K., …Groom, M. J. (2019). Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders. BMC Medical Research Methodology, 19, 1-13. https://doi.org/10.1186/s12874-019-0772-2

Background The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity... Read More about Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders.

Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study (2019)
Journal Article
Hollis, C., Chen, Q., Chang, Z., Quinn, P. D., Viktorin, A., Lichtenstein, P., …Larsson, H. (2019). Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study. Lancet Psychiatry, 6(8), 651-658. https://doi.org/10.1016/s2215-0366%2819%2930189-0

Background: There is a clinical concern that prescribing methylphenidate, the most common pharmacological treatment for attention-deficit hyperactivity disorder (ADHD), might increase the risk of psychotic events, particularly in young people with a... Read More about Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study.

A Feasibility Trial of Power Up: Smartphone App to Support Patient Activation and Shared Decision Making for Mental Health in Young People (2019)
Journal Article
Edbrooke-Childs, J., Edridge, C., Averill, P., Delane, L., Hollis, C., Carven, M., …Wolpert, M. (2019). A Feasibility Trial of Power Up: Smartphone App to Support Patient Activation and Shared Decision Making for Mental Health in Young People. JMIR mHealth and uHealth, 7(6), Article e11677. https://doi.org/10.2196/11677

Background: Digital tools have the potential to support patient activation and shared decision making in the face of increasing levels of mental health problems in young people. There is a need for feasibility trials of digital interventions to deter... Read More about A Feasibility Trial of Power Up: Smartphone App to Support Patient Activation and Shared Decision Making for Mental Health in Young People.

Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report (2019)
Journal Article
Palaniyappan, L., Batty, M. J., Liddle, P. F., Liddle, E. B., Groom, M. J., Hollis, C., & Scerif, G. (2019). Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report. Frontiers in Psychiatry, 10, Article 235. https://doi.org/10.3389/fpsyt.2019.00235

Objective: Structural and functional abnormalities have been noted in the prefrontal cortex of individuals with neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD). Cortical thickness and gyrification, both of which h... Read More about Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report.

The Validity of the SNAP-IV in Children Displaying ADHD Symptoms (2019)
Journal Article
Hall, C. L., Guo, B., Valentine, A. Z., Groom, M. J., Daley, D., Sayal, K., & Hollis, C. (2020). The Validity of the SNAP-IV in Children Displaying ADHD Symptoms. Assessment, 27(6), 1258-1271. https://doi.org/10.1177/1073191119842255

The Swanson, Nolan, and Pelham Rating Scale (SNAP-IV) is a widely used scale that measures the core symptoms of attention deficit hyperactivity disorder (ADHD). However, there are contradictory findings regarding factor structure. Factor structure an... Read More about The Validity of the SNAP-IV in Children Displaying ADHD Symptoms.

Investigating a therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents: 'Online Remote Behavioural Intervention for Tics' (ORBIT) trial: protocol of an internal pilot study and single randomised controlled trial (2019)
Journal Article
Hall, C. L., Davies, E. B., Andrén, P., Murphy, T., Bennett, S., Brown, B. J., …Hollis, C. (2019). Investigating a therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents: 'Online Remote Behavioural Intervention for Tics' (ORBIT) trial: protocol of an internal pilot study and single randomised controlled trial. BMJ Open, 9(1), Article e027583. https://doi.org/10.1136/bmjopen-2018-027583

Introduction Tourette syndrome and chronic tic disorder are common, disabling childhood-onset conditions. Guidelines recommend that behavioural therapy should be offered as first-line treatment for children with tics. However, there are very few t... Read More about Investigating a therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents: 'Online Remote Behavioural Intervention for Tics' (ORBIT) trial: protocol of an internal pilot study and single randomised controlled trial.

Towards a consensus around standards for smartphone apps and digital mental health (2019)
Journal Article
John Torous, J., Anderson, G., Bertagnoli, A., Christensen, H., Cuijpers, P., Firth, J., …Arean, P. A. (2019). Towards a consensus around standards for smartphone apps and digital mental health. World Psychiatry, 18(1), 97-98. https://doi.org/10.1002/wps.20592

Mental disorders impact one in four people worldwide, yet access to care is challenging for those who suffer from them1. Mental health apps offer the potential to overcome access barriers for the nearly three billion people projected to own a smartph... Read More about Towards a consensus around standards for smartphone apps and digital mental health.

The use of the QbTest in clinical practice (2018)
Journal Article
Hall, C. L., & Hollis, C. (2018). The use of the QbTest in clinical practice. ADHD in Practice, 10(3), 49-52

Diagnosing and managing attention deficit and hyperactivity disorder (ADHD) typically relies on subjective measures. When assessing children and young people for ADHD, the clinician gathers information from parents and teachers and uses these various... Read More about The use of the QbTest in clinical practice.

Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2018)
Journal Article
McCarthy, S., Neubert, A., Man, K. K. C., Banaschewski, T., Buitelaar, J., Carucci, S., …Wong, I. C. K. (2018). Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). BMC Psychiatry, 18(1), Article 327. https://doi.org/10.1186/s12888-018-1884-7

© 2018 The Author(s). Background: Concerns have been raised over the safety of methylphenidate (MPH), with regard to adverse effects on growth and blood pressure. Our study investigates whether, and to what extent, methylphenidate use in boys with AD... Read More about Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed (2018)
Journal Article
Retzler, J., Johnson, S., Groom, M., Hollis, C., Budge, H., & Cragg, L. (2019). Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed. Child Neuropsychology, 25(5), 617-635. https://doi.org/10.1080/09297049.2018.1510908

Background: Inattention is one of the most common neurobehavioural problems following very preterm birth. Attention problems can persist into adulthood and are associated with negative socio-emotional and educational outcomes. This study aimed to det... Read More about Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed.

Identifying research priorities for digital technology in mental healthcare: results of the James Lind Alliance Priority Setting Partnership (2018)
Journal Article
Hollis, C., Sampson, S., Simons, L., Davies, E. B., Churchill, R., Betton, V., …Tomlin, A. (2018). Identifying research priorities for digital technology in mental healthcare: results of the James Lind Alliance Priority Setting Partnership. Lancet Psychiatry, 5(10), 845-854. https://doi.org/10.1016/S2215-0366%2818%2930296-7

© 2018 Elsevier Ltd Digital technology, including the internet, smartphones, and wearables, provides the possibility to bridge the mental health treatment gap by offering flexible and tailored approaches to mental health care that are more accessible... Read More about Identifying research priorities for digital technology in mental healthcare: results of the James Lind Alliance Priority Setting Partnership.

Investigating user needs and integration of Remote Measuring Technologies into clinical practice (2018)
Conference Proceeding
Lang, A., Craven, M., Hollis, C., & Morriss, R. (2018). Investigating user needs and integration of Remote Measuring Technologies into clinical practice

Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis (2018)
Journal Article
Cortese, S., Adamo, N., Del Giovane, C., Mohr-Jensen, C., Hayes, A. J., Carucci, S., …Cipriani, A. (2018). Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry, 5(9), 727-738. https://doi.org/10.1016/S2215-0366%2818%2930269-4

© 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines ar... Read More about Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis.

The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial (2018)
Journal Article
the AQUA Trial Group, Hollis, C., Hall, C. L., Guo, B., James, M., Boadu, J., …Morriss, R. (2018). The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial. Journal of Child Psychology and Psychiatry, 59(12), 1298-1308. https://doi.org/10.1111/jcpp.12921

© 2018 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. Background: Diagnosis of attention deficit hyperactivity disorder (ADHD) relies on su... Read More about The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial.

Protocol investigating the clinical utility of an objective measure of attention, impulsivity and activity (QbTest) for optimising medication management in children and young people with ADHD ‘QbTest Utility for Optimising Treatment in ADHD’ (QUOTA): a feasibility randomised controlled trial (2018)
Journal Article
Hall, C. L., James, M., Brown, S., Martin, J. L., Brown, N., Selby, K., …Groom, M. J. (2018). Protocol investigating the clinical utility of an objective measure of attention, impulsivity and activity (QbTest) for optimising medication management in children and young people with ADHD ‘QbTest Utility for Optimising Treatment in ADHD’ (QUOTA): a feasibility randomised controlled trial. BMJ Open, 8(2), Article e021104. https://doi.org/10.1136/bmjopen-2017-021104

Introduction: Attention-deficit hyperactivity disorder (ADHD) is characterised by symptoms of inattention, hyperactivity and impulsivity. To improve outcomes, the National Institute for Health and Care Excellence ADHD guidelines recommend regular mon... Read More about Protocol investigating the clinical utility of an objective measure of attention, impulsivity and activity (QbTest) for optimising medication management in children and young people with ADHD ‘QbTest Utility for Optimising Treatment in ADHD’ (QUOTA): a feasibility randomised controlled trial.

Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial (2017)
Journal Article
Kaylor-Hughes, C., Rawsthorne, M., Coulson, N. S., Simpson, S., Simons, L., Guo, B., …Morriss, R. (in press). Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial. Journal of Medical Internet Research, 6(12), Article e231. https://doi.org/10.2196/resprot.8061

Regardless of geography or income, effective help for depression and anxiety only reaches a small proportion of those who might benefit from it. The scale of the problem suggests a role for effective, safe, anonymised public health driven online serv... Read More about Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial.

Direct to Public Peer Support and e-Therapy Program Versus Information to Aid Self-Management of Depression and Anxiety: Protocol for a Randomized Controlled Trial (Preprint) (2017)
Other
Kaylor-Hughes, C. J., Rawsthorne, M., Coulson, N. S., Simpson, S., Simons, L., Guo, B., …REBOOT Notts Lived Experience Advisory Panel. (2017). Direct to Public Peer Support and e-Therapy Program Versus Information to Aid Self-Management of Depression and Anxiety: Protocol for a Randomized Controlled Trial (Preprint)

A mobile phone app to support young people in making shared decisions in therapy (Power Up): study protocol (2017)
Journal Article
Chapman, L., Edbrooke-Childs, J., Martin, K., Webber, H., Craven, M. P., Hollis, C., …Wolpert, M. (2017). A mobile phone app to support young people in making shared decisions in therapy (Power Up): study protocol. JMIR Research Protocols, 6(10), Article e206. https://doi.org/10.2196/resprot.7694

Background: Evidence suggests that young people want to be active participants in their care and involved in decisions about their treatment. However, there is a lack of digital shared decision-making tools available to support young people in child... Read More about A mobile phone app to support young people in making shared decisions in therapy (Power Up): study protocol.

Practitioner review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD) (2017)
Journal Article
Daley, D., Van Der Oord, S., Ferrin, M., Cortese, S., Danckaerts, M., Doepfne, M., …Sonuga-Barke, E. J. (2018). Practitioner review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). Journal of Child Psychology and Psychiatry, 59(9), 932-947. https://doi.org/10.1111/jcpp.12825

Background: Behavioural interventions are recommended for use with children and young people with ADHD, however specific guidance for their implementation based on the best available evidence is currently lacking. Methods: This review used an explic... Read More about Practitioner review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD).

Adjunctive avatar therapy for mentalization based treatment of borderline personality disorder: a mixed methods feasibility study (2017)
Journal Article
Falconer, C. J., Cutting, P., Davies, E. B., Hollis, C., Stallard, P., & Moran, P. (in press). Adjunctive avatar therapy for mentalization based treatment of borderline personality disorder: a mixed methods feasibility study. Evidence-Based Mental Health, 20(4), https://doi.org/10.1136/eb-2017-102761

Background: Borderline personality disorder (BPD) is characterized by severe instability in emotions, identity, relationships, and impulsive behaviour. One contributing factor to BPD is deficient mentalizing - our ability to understand the mental sta... Read More about Adjunctive avatar therapy for mentalization based treatment of borderline personality disorder: a mixed methods feasibility study.

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis (2017)
Journal Article
Freeman, D., Sheaves, B., Goodwin, G. M., Yu, L., Nickless, A., Harrison, P. J., …Espie, C. A. (2017). The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. Lancet Psychiatry, 4(10), 749-758. https://doi.org/10.1016/S2215-0366%2817%2930328-0

Background Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduc... Read More about The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis.

Association of Risk of Suicide Attempts With Methylphenidate Treatment (2017)
Journal Article
Man, K. K., Coghill, D., Chan, E. W., Lau, W. C., Hollis, C., Liddle, E., …Wong, I. C. (2017). Association of Risk of Suicide Attempts With Methylphenidate Treatment. JAMA Psychiatry, 74(10), 1048-1055. https://doi.org/10.1001/jamapsychiatry.2017.2183

IMPORTANCE Patients with attention-deficit/hyperactivity disorder (ADHD) are at an increased risk of attempting suicide. Stimulants, such as methylphenidate hydrochloride, are the most common treatment for ADHD, but the association between their ther... Read More about Association of Risk of Suicide Attempts With Methylphenidate Treatment.

Atypical processing of gaze cues and faces explains comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) (2017)
Journal Article
Groom, M. J., Kochhar, P., Hamilton, A., Liddle, E. B., Simeou, M., & Hollis, C. (2017). Atypical processing of gaze cues and faces explains comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Journal of Autism and Developmental Disorders, 47(5), https://doi.org/10.1007/s10803-017-3078-4

This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on b... Read More about Atypical processing of gaze cues and faces explains comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD).

Study of user-experience of an objective test (QbTest) to aid ADHD assessment and medication management: a multi-methods approach (2017)
Journal Article
Hall, C. L., Valentine, A., Walker, G. M., Ball, H. M., Cogger, H., Daley, D., …Hollis, C. (2017). Study of user-experience of an objective test (QbTest) to aid ADHD assessment and medication management: a multi-methods approach. BMC Psychiatry, 17, Article 66. https://doi.org/10.1186/s12888-017-1222-5

Background The diagnosis and monitoring of Attention deficit hyperactivity disorder (ADHD) typically relies on subjective reports and observations. Objective continuous performance tests (CPTs) have been incorporated into some services to support... Read More about Study of user-experience of an objective test (QbTest) to aid ADHD assessment and medication management: a multi-methods approach.

Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review (2016)
Journal Article
Hollis, C., Falconer, C. J., Martin, J. L., Whittington, C., Stockton, S., Glazebrook, C., & Davies, E. B. (in press). Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review. Journal of Child Psychology and Psychiatry, https://doi.org/10.1111/jcpp.12663

Digital health interventions (DHIs), including computer-assisted therapy, smartphone apps and wearable technologies, are heralded as having enormous potential to improve uptake and accessibility, efficiency, clinical effectiveness and personalisation... Read More about Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review.

Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system (2016)
Journal Article
Man, K. K., Coghill, D., Chan, E. W., Lau, W. C., Hollis, C., Liddle, E., …Wong, I. C. (in press). Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system. Translational Psychiatry, 6, Article e956. https://doi.org/10.1038/tp.2016.216

Previous studies have suggested that risk of psychotic events may be increased in children exposed to methylphenidate (MPH). However, this risk has not been fully examined and the possibility of confounding factors has not been excluded. Patients age... Read More about Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system.

The incremental validity of a computerised assessment added to clinical rating scales to differentiate adult ADHD from autism spectrum disorder (2016)
Journal Article
Groom, M. J., Young, Z., Hall, C. L., Gillott, A., & Hollis, C. (2016). The incremental validity of a computerised assessment added to clinical rating scales to differentiate adult ADHD from autism spectrum disorder. Psychiatry Research, 243, https://doi.org/10.1016/j.psychres.2016.06.042

There is a clinical need for objective evidence-based measures that are sensitive and specific to ADHD when compared with other neurodevelopmental disorders. This study evaluated the incremental validity of adding an objective measure of activity and... Read More about The incremental validity of a computerised assessment added to clinical rating scales to differentiate adult ADHD from autism spectrum disorder.

Effectiveness and cost-effectiveness of a brief school-based group programme for parents of children at risk of ADHD: a cluster randomised controlled trial (2016)
Journal Article
Sayal, K., Taylor, J. A., Valentine, A., Guo, B., Sampson, C. J., Sellman, E., …Daley, D. (2016). Effectiveness and cost-effectiveness of a brief school-based group programme for parents of children at risk of ADHD: a cluster randomised controlled trial. Child: Care, Health and Development, 42(4), 521-533. https://doi.org/10.1111/cch.12349

Background NICE guidelines recommend a stepped care approach for the identification and management of children with, or at risk of, Attention-Deficit / Hyperactivity Disorder (ADHD). We investigated the effectiveness, cost-effectiveness and acceptab... Read More about Effectiveness and cost-effectiveness of a brief school-based group programme for parents of children at risk of ADHD: a cluster randomised controlled trial.

Practitioner review: Treatments for Tourette syndrome in children and young people: a systematic review (2016)
Journal Article
Whittington, C., Pennant, M., Kendall, T., Glazebrook, C., Trayner, P., Groom, M. J., …Hollis, C. (in press). Practitioner review: Treatments for Tourette syndrome in children and young people: a systematic review. Journal of Child Psychology and Psychiatry, 57(9), 988-1004. https://doi.org/10.1111/jcpp.12556

Background: Tourette syndrome (TS) and chronic tic disorder (CTD) affect 1–2% of children and young people, but the most effective treatment is unclear. To establish the current evidence base, we conducted a systematic review of interventions for ch... Read More about Practitioner review: Treatments for Tourette syndrome in children and young people: a systematic review.

Developing mHealth Remote Monitoring Technology for Attention Deficit Hyperactivity Disorder: A Qualitative Study Eliciting User Priorities and Needs (2016)
Journal Article
Simons, L., Valentine, A. Z., Falconer, C. J., Groom, M., Daley, D., Craven, M. P., …Hollis, C. (2016). Developing mHealth Remote Monitoring Technology for Attention Deficit Hyperactivity Disorder: A Qualitative Study Eliciting User Priorities and Needs. JMIR mHealth and uHealth, 4(1), Article e31. https://doi.org/10.2196/mhealth.5009

Background: Guidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic c... Read More about Developing mHealth Remote Monitoring Technology for Attention Deficit Hyperactivity Disorder: A Qualitative Study Eliciting User Priorities and Needs.

Correction: Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD-'Assessing QbTest Utility in ADHD'(AQUA): A randomised controlled trial - December 01, 2014 (2016)
Journal Article
Hall, C. L., Walker, G. M. .., Valentine, A. Z., Guo, B., Kaylor-Hughes, C., James, M., …Hollis, C. (2016). Correction: Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD-'Assessing QbTest Utility in ADHD'(AQUA): A randomised controlled trial - December 01, 2014. BMJ Open, 6(1), Article e006838corr2. https://doi.org/10.1136/bmjopen-2014-006838corr2

The challenges of implementing ADHD clinical guidelines and research best evidence in routine clinical care settings: a Delphi survey and mixed-methods study (2016)
Journal Article
Hall, C. L., Taylor, J. A., Newell, K., Baldwin, L., Sayal, K., & Hollis, C. (2016). The challenges of implementing ADHD clinical guidelines and research best evidence in routine clinical care settings: a Delphi survey and mixed-methods study. BJPsych Open, 2(1), 25-31. https://doi.org/10.1192/bjpo.bp.115.002386

Background:The landmark US Multimodal Treatment of ADHD (MTA) study established the benefits of individualised medication titration and optimisation strategies to improve short- to medium-term outcomes in attention-deficit hyperactivity disorder (ADH... Read More about The challenges of implementing ADHD clinical guidelines and research best evidence in routine clinical care settings: a Delphi survey and mixed-methods study.

Innovations in practice: an objective measure of attention, impulsivity and activity reduces time to confirm attention deficit/hyperactivity disorder diagnosis in children: a completed audit cycle (2016)
Journal Article
Hall, C. L., Selby, K., Guo, B., Valentine, A. Z., Walker, G. M., & Hollis, C. (2016). Innovations in practice: an objective measure of attention, impulsivity and activity reduces time to confirm attention deficit/hyperactivity disorder diagnosis in children: a completed audit cycle. Child and Adolescent Mental Health, 21(3), 175-178. https://doi.org/10.1111/camh.12140

Background Diagnosing attention deficit/hyperactivity disorder (ADHD) in children and young people typically relies on clinical observation and subjective parent, teacher and self-reports. The subjective nature of reports combined with contradicto... Read More about Innovations in practice: an objective measure of attention, impulsivity and activity reduces time to confirm attention deficit/hyperactivity disorder diagnosis in children: a completed audit cycle.

Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis (2016)
Journal Article
Hollis, C., Pennant, M., Cuenca, J., Glazebrook, C., Kendall, T., Whittington, C., …Stern, J. (2016). Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis. Health Technology Assessment, 20(4), 1-450. https://doi.org/10.3310/hta20040

Background: Tourette syndrome (TS) is a neurodevelopmental condition characterised by chronic motor and vocal tics affecting up to 1% of school-age children and young people and is associated with significant distress and psychosocial impairment. Ob... Read More about Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis.

The clinical utility of the continuous performance test and objective measures of activity for diagnosing and monitoring ADHD in children: a systematic review (2015)
Journal Article
Hall, C. L., Valentine, A., Groom, M. J., Walker, G. M., Sayal, K., Daley, D., & Hollis, C. (2016). The clinical utility of the continuous performance test and objective measures of activity for diagnosing and monitoring ADHD in children: a systematic review. European Child and Adolescent Psychiatry, 25(7), 677-699. https://doi.org/10.1007/s00787-015-0798-x

Attention deficit hyperactivity disorder (ADHD) is typically diagnosed using clinical observation and subjective informant reports. Once children commence ADHD medication, robust monitoring is required to detect partial or non-responses. The extent t... Read More about The clinical utility of the continuous performance test and objective measures of activity for diagnosing and monitoring ADHD in children: a systematic review.

Enhanced saccadic control in young people with Tourette syndrome despite slowed pro-saccades (2015)
Journal Article
Jung, J., Jackson, S. R., Nam, K., Hollis, C., & Jackson, G. M. (2015). Enhanced saccadic control in young people with Tourette syndrome despite slowed pro-saccades. Journal of Neuropsychology, 9(2), https://doi.org/10.1111/jnp.12044

Tourette syndrome (TS) is a neurodevelopmental disorder characterised by motor and vocal tics. Tics are repetitive and uncontrolled behaviours that have been associated with basal ganglia dysfunction. We investigated saccadic eye movements in a group... Read More about Enhanced saccadic control in young people with Tourette syndrome despite slowed pro-saccades.

Driving behaviour in adults with attention deficit/hyperactivity disorder (2015)
Journal Article
Groom, M. J., van Loon, E., Daley, D., Chapman, P., & Hollis, C. (2015). Driving behaviour in adults with attention deficit/hyperactivity disorder. BMC Psychiatry, 15(1), 1-11. https://doi.org/10.1186/s12888-015-0566-y

Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder (2015)
Journal Article
Batty, M. J., Palaniyappan, L., Scerif, G., Groom, M. J., Liddle, E. B., Liddle, P. F., & Hollis, C. (2015). Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder. Psychiatry Research: Neuroimaging, 233(2), 225-232. doi:10.1016/j.pscychresns.2015.07.004

Although previous morphological studies have demonstrated abnormalities in prefrontal cortical thickness in children with attention deficit/hyperactivity disorder (ADHD), studies investigating cortical surface area are lacking. As the development of... Read More about Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Correction: Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD - 'Assessing QbTest Utility in ADHD' (AQUA): A randomised controlled trial - December 01, 2014 (2015)
Journal Article
Hall, C. L., Walker, G. M., Valentine, A. Z., Guo, B., Kaylor-Hughes, C., James, M., …Hollis, C. (2015). Correction: Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD - 'Assessing QbTest Utility in ADHD' (AQUA): A randomised controlled trial - December 01, 2014. BMJ Open, 5(5), Article e006838corr1. https://doi.org/10.1136/bmjopen-2014-006838corr1

Technological innovations in mental healthcare: harnessing the digital revolution (2015)
Journal Article
Hollis, C., Morriss, R., Martin, J., Amani, S., Cotton, R., Denis, M., & Lewis, S. (2015). Technological innovations in mental healthcare: harnessing the digital revolution. British Journal of Psychiatry, 206(4), https://doi.org/10.1192/bjp.bp.113.142612

Digital technology has the potential to transform mental healthcare by connecting patients, services and health data in new ways. Digital online and mobile applications can offer patients greater access to information and services and enhance clinica... Read More about Technological innovations in mental healthcare: harnessing the digital revolution.

Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial (2014)
Journal Article
Hall, C. L., Walker, G. M., Valentine, A. Z., Guo, B., Kaylor-Hughes, C., James, M., …Hollis, C. (2014). Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial. BMJ Open, 4(12), Article e006838. https://doi.org/10.1136/bmjopen-2014-006838

Introduction: The National Institute for Health and Care Excellence (NICE) guidelines for attention deficit/hyperactivity disorder (ADHD) state that young people need to have access to the best evidence-based care to improve outcome. The current ‘gol... Read More about Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial.

Services for young people with attention deficit/hyperactivity disorder transitioning from child to adult mental health services: a national survey of mental health trusts in England. (2014)
Journal Article
Hall, C. L., Newell, K., Taylor, J., Sayal, K., & Hollis, C. (2015). Services for young people with attention deficit/hyperactivity disorder transitioning from child to adult mental health services: a national survey of mental health trusts in England. Journal of Psychopharmacology, 29(1), https://doi.org/10.1177/0269881114550353

Transition from child to adult mental health services is considered to be a difficult process, particularly for individuals with neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD). This article presents results from... Read More about Services for young people with attention deficit/hyperactivity disorder transitioning from child to adult mental health services: a national survey of mental health trusts in England..

Innovations in practice: piloting electronic session-by-session monitoring in child and adolescent mental health : a preliminary study (2014)
Journal Article
Hall, C. L., Moldavsky, M., Taylor, J. A., Marriott, M., Goodman, R., Sayal, K., & Hollis, C. (2015). Innovations in practice: piloting electronic session-by-session monitoring in child and adolescent mental health : a preliminary study. Child and Adolescent Mental Health, 20(3), https://doi.org/10.1111/camh.12066

Background Recent UK initiatives have advocated the use of session-by-session outcome measurement in CAMHS. However, little is known about the feasibility of this approach. Method The PROMPT study (Patient Reported Outcome Monitoring Progres... Read More about Innovations in practice: piloting electronic session-by-session monitoring in child and adolescent mental health : a preliminary study.

A qualitative process evaluation of electronic session-by-session outcome measurement in child and adolescent mental health services (2014)
Journal Article
Hall, C. L., Taylor, J., Moldavsky, M., Marriott, M., Pass, S., Newell, K., …Hollis, C. (2014). A qualitative process evaluation of electronic session-by-session outcome measurement in child and adolescent mental health services. BMC Psychiatry, 14(113), https://doi.org/10.1186/1471-244X-14-113

Background Regular monitoring of patient progress is important to assess the clinical effectiveness of an intervention. Recently, initiatives within UK child and adolescent mental health services (CAMHS) have advocated the use of session-by-session... Read More about A qualitative process evaluation of electronic session-by-session outcome measurement in child and adolescent mental health services.

The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle (2013)
Journal Article
Hall, C. L., Moldavsky, M., Baldwin, L., Marriott, M., Newell, K., Taylor, J., …Hollis, C. (2013). The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle. BMC Psychiatry, 13(270), https://doi.org/10.1186/1471-244X-13-270

Background: Routine outcome measurement (ROM) is important for assessing the clinical effectiveness of health services and for monitoring patient outcomes. Within Child and Adolescent Mental Health Services (CAMHS) in the UK the adoption of ROM in C... Read More about The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle.

Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder (2013)
Journal Article
Groom, M. J., Liddle, E. B., Scerif, G., Liddle, P. F., Batty, M. J., Liotti, M., & Hollis, C. (2013). Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 54(8), https://doi.org/10.1111/jcpp.12069

Background Children with attention deficit hyperactivity disorder (ADHD) are characterised by developmentally inappropriate levels of hyperactivity, impulsivity and/or inattention and are particularly impaired when performing tasks that require a hi... Read More about Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder.

Implementation of routine outcome measurement in child and adolescent mental health services in the United Kingdom: A critical perspective (2013)
Journal Article
Hall, C., Moldavsky, M., Taylor, J., Sayal, K., Marriott, M., Batty, M., …Hollis, C. (2014). Implementation of routine outcome measurement in child and adolescent mental health services in the United Kingdom: A critical perspective. European Child and Adolescent Psychiatry, 23, 239–242. https://doi.org/10.1007/s00787-013-0454-2

‘Mind the gap’ - mapping services for young people with ADHD transitioning from child to adult mental health services (2013)
Journal Article
Hall, C. L., Newell, K., Taylor, J., Sayal, K., Swift, K. D., & Hollis, C. (2013). ‘Mind the gap’ - mapping services for young people with ADHD transitioning from child to adult mental health services. BMC Psychiatry, 13(186), https://doi.org/10.1186/1471-244X-13-186

Background: Once considered to be a disorder restricted to childhood, Attention Deficit/Hyperactivity Disorder (ADHD) is now recognised to persist into adult life. However, service provision for adults with ADHD is limited. Additionally, there is lit... Read More about ‘Mind the gap’ - mapping services for young people with ADHD transitioning from child to adult mental health services.

Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences (2013)
Journal Article
Swift, K. D., Hall, C. L., Marimuttu, V., Redstone, L., Sayal, K., & Hollis, C. (2013). Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences. BMC Psychiatry, 13, Article 74. https://doi.org/10.1186/1471-244X-13-74

Background There is little research on the process of transition between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS). More recently, there is growing recognition that Attention Deficit/Hyperactivity Di... Read More about Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences.

Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol (2012)
Journal Article
Sayal, K., Daley, D., James, M., Yang, M., Batty, M. J., Taylor, J. A., …Hollis, C. (2012). Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol. BMJ Open, 2(5), Article e001783. https://doi.org/10.1136/bmjopen-2012-001783

Introduction Early intervention for childhood behavioural problems may help improve health and educational outcomes in affected children and reduce the likelihood of developing additional difficulties. The National Institute for Health and Clinical... Read More about Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol.

Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK) (2011)
Journal Article
Glazebrook, C., Batty, M. J., Mullan, N., MacDonald, I., Nathan, D., Sayal, K., …Hollis, C. (2011). Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK). BMC Public Health, 11, Article 830. https://doi.org/10.1186/1471-2458-11-830

Background Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy). Factors which can impact on confidence include a chronic hea... Read More about Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK).

Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate (2011)
Journal Article
Liddle, E. B., Hollis, C., Batty, M. J., Groom, M. J., Totman, J. J., Liotti, M., …Liddle, P. F. (2011). Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate. Journal of Child Psychology and Psychiatry, 52(7), https://doi.org/10.1111/j.1469-7610.2010.02333.x

Background: Deficits characteristic of Attention Deficit/Hyperactivity Disorder (ADHD), including poor attention and inhibitory control, are at least partially alleviated by factors that increase engagement of attention, suggesting a hypodopaminergic... Read More about Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate.

Compensatory Neural Reorganization in Tourette Syndrome (2011)
Journal Article
Jackson, G., Jackson, S., Parkinson, A., Hollis, C., Jung, J., Ryan, S., & Morgan, P. (2011). Compensatory Neural Reorganization in Tourette Syndrome. Current Biology, 21(7), 580-585. https://doi.org/10.1016/j.cub.2011.02.047

Children with neurological disorders may follow unique developmental trajectories whereby they undergo compensatory neuroplastic changes in brain structure and function that help them gain control over their symptoms [1, 2, 3, 4, 5, 6]. We used behav... Read More about Compensatory Neural Reorganization in Tourette Syndrome.

Associative learning in ADHD: improved expression under methylphenidate (2011)
Journal Article
Kantini, E., Cassaday, H. J., Batty, M. J., Hollis, C., & Jackson, G. M. (2011). Associative learning in ADHD: improved expression under methylphenidate. Open Journal of Psychiatry, 1(2), https://doi.org/10.4236/ojpsych.2011.12004

Attention Deficit/Hyperactivity Disorder (ADHD) is characterised by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. As might be expected of a disorder in which inhibitory deficits form part of the diagnostic criter... Read More about Associative learning in ADHD: improved expression under methylphenidate.

The normal inhibition of associations is impaired by clonidine in Tourette syndrome (2011)
Journal Article
Kantini, E., Cassaday, H. J., Hollis, C., & Jackson, G. M. (2011). The normal inhibition of associations is impaired by clonidine in Tourette syndrome. Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 20(2),

Objective: We examined the inhibition of stimulus-stimulus associations (formally ‘conditioned inhibition’) in Tourette syndrome (TS). Method: The present study used video game style conditioned inhibition procedures suitable for children and adolesc... Read More about The normal inhibition of associations is impaired by clonidine in Tourette syndrome.

Indices of heart rate variability and performance during a response-conflict task are differently associated with ADHD and autism (2002)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Hollis, C., & Groom, M. J. (2002). Indices of heart rate variability and performance during a response-conflict task are differently associated with ADHD and autism. Journal of Attention Disorders, 26(3), 434-446. https://doi.org/10.1177/1087054720972793

Objective. We investigated autonomic arousal, attention and response conflict, in ADHD and autism. Method. Heart rate variability (HRV), and behavioural and electrophysiological indices of performance, were recorded during a task with low and hig... Read More about Indices of heart rate variability and performance during a response-conflict task are differently associated with ADHD and autism.

High-quality antidepressant prescribing in children and young people: value of observational research
Other
Joseph, R. M., Jack, R. H., Hollis, C., & Coupland, C. (2020). High-quality antidepressant prescribing in children and young people: value of observational research