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Professor CHRIS HOLLIS's Outputs (123)

A 10-week remote monitoring study of sleep features and their variability in individuals with and without ADHD (2025)
Journal Article
Denyer, H., Carr, E., Deng, Q., Asherson, P., Bilbow, A., Folarin, A., Groom, M. J., Hollis, C., Sankesara, H., Dobson, R. J., & Kuntsi, J. (2025). A 10-week remote monitoring study of sleep features and their variability in individuals with and without ADHD. BMC Psychiatry, 25, Article 294. https://doi.org/10.1186/s12888-025-06729-z

Background
People with attention deficit hyperactivity disorder (ADHD) often report disturbed sleep, as well as co-occurring symptoms of anxiety and depression. Yet studies employing objective assessments often do not show as many sleep disturbances... Read More about A 10-week remote monitoring study of sleep features and their variability in individuals with and without ADHD.

Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD – are we there yet? (2024)
Journal Article
Bellato, A., Parlatini, V., Groom, M. J., Hall, C. L., Hollis, C., Simonoff, E., Thapar, A., & Cortese, S. (2025). Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD – are we there yet?. Journal of Child Psychology and Psychiatry, 66(2), 266-270. https://doi.org/10.1111/jcpp.14071

Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants). Accurately and promptly detecting treatment-related improvements, response failure, or deter... Read More about Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD – are we there yet?.

Healthcare utilisation and costs associated with poor access to diagnosis and treatment for children and young people with tic disorders (2024)
Journal Article
Hall, C. L., Le Novere, M., Murphy, T., McNally, E., Hollis, C., & Hunter, R. (2024). Healthcare utilisation and costs associated with poor access to diagnosis and treatment for children and young people with tic disorders. BMJ Mental Health, 27(1), Article e301241. https://doi.org/10.1136/bmjment-2024-301241

BACKGROUND: There are no specific national guidelines in England to guide healthcare professionals in how to assess or treat young people with tic disorders. Access to evidence-based treatment, including behavioural therapy, is of limited availabilit... Read More about Healthcare utilisation and costs associated with poor access to diagnosis and treatment for children and young people with tic disorders.

Dynamic Interplay of Online Risk and Resilience in Adolescence (DIORA): a protocol for a 12-month prospective observational study testing the associations among digital activity, affective and cognitive reactions and depression symptoms in a community sample of UK adolescents (2024)
Journal Article
Kostyrka-Allchorne, K., Stoilova, M., Bourgaize, J., Murray, A., Azeri, E., Hollis, C., Townsend, E., Livingstone, S., & Sonuga-Barke, E. (2024). Dynamic Interplay of Online Risk and Resilience in Adolescence (DIORA): a protocol for a 12-month prospective observational study testing the associations among digital activity, affective and cognitive reactions and depression symptoms in a community sample of UK adolescents. BMJ Open, 14(9), Article e085061. https://doi.org/10.1136/bmjopen-2024-085061

Introduction The impact of digital activity on adolescent mental health has been difficult to assess because of methodological limitations and a lack of strong theory. Dynamic Interplay of Online Risk and Resilience in Adolescence (DIORA) is a longit... Read More about Dynamic Interplay of Online Risk and Resilience in Adolescence (DIORA): a protocol for a 12-month prospective observational study testing the associations among digital activity, affective and cognitive reactions and depression symptoms in a community sample of UK adolescents.

Pathways between digital activity and depressed mood in adolescence: outlining a developmental model integrating risk, reactivity, resilience and reciprocity (2024)
Journal Article
Sonuga-Barke, E. J., Stoilova, M., Kostyrka-Allchorne, K., Bourgaize, J., Murray, A., Tan, M. P., Hollis, C., Townsend, E., & Livingstone, S. (2024). Pathways between digital activity and depressed mood in adolescence: outlining a developmental model integrating risk, reactivity, resilience and reciprocity. Current Opinion in Behavioral Sciences, 58, Article 101411. https://doi.org/10.1016/j.cobeha.2024.101411

Digital technology use (i.e. digital activity) has been proposed to contribute to a decline in adolescents’ mental health. We present a new model of how risky digital activity may increase depressed mood via reciprocal pathways, cre... Read More about Pathways between digital activity and depressed mood in adolescence: outlining a developmental model integrating risk, reactivity, resilience and reciprocity.

Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-month Follow-Up of a Randomized Clinical Trial (2024)
Journal Article
Andrén, P., Sampaio, F., Ringberg, H., Wachtmeister, V., Warnström, M., Isomura, K., Aspvall, K., Lenhard, F., Hall, C. L., Davies, E. B., Murphy, T., Hollis, C., Feldman, I., Bottai, M., Serlachius, E., Andersson, E., Fernández de la Cruz, L., & Mataix-Cols, D. (2024). Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-month Follow-Up of a Randomized Clinical Trial. JAMA Network Open, 7(5), Article e248468. https://doi.org/10.1001/jamanetworkopen.2024.8468

Importance: Behavior therapy is a recommended intervention for Tourette syndrome (TS) and chronic tic disorder (CTD), but availability is limited and long-term effects are uncertain.

Objective: To investigate the long-term efficacy and cost-effec... Read More about Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-month Follow-Up of a Randomized Clinical Trial.

Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK (2024)
Journal Article
Khan, K., Hall, C. L., Babbage, C., Dodzo, S., Greenhalgh, C., Lucassen, M., Merry, S., Sayal, K., Sprange, K., Stasiak, K., Tench, C. R., Townsend, E., Stallard, P., & Hollis, C. (2024). Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK. Pilot and Feasibility Studies, 10(1), Article 53. https://doi.org/10.1186/s40814-024-01475-7

Background : A serious game called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), originally developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depressi... Read More about Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK.

Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial (2024)
Journal Article
Williams, A. J., Cleare, S., Borschmann, R., Tench, C. R., Gross, J., Hollis, C., Chapman-Nisar, A., Naeche, N., Townsend, E., & Slovak, P. (2024). Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial. BMJ Open, 14(1), Article e079801. https://doi.org/10.1136/bmjopen-2023-079801

Introduction: Purrble, a socially assistive robot, was codesigned with children to support in situ emotion regulation. Preliminary evidence has found that LGBTQ+ youth are receptive to Purrble and find it to be an acceptable intervention to assist wi... Read More about Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial.

Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies (2023)
Journal Article
Williams, A. J., Townsend, E., Naeche, N., Chapman-Nisar, A., Hollis, C., & Slovak, P. (2023). Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies. JMIR Formative Research, 7(1), Article e52336. https://doi.org/10.2196/52336

Background: Minority youth are at an increased risk of experiencing self-harmful thoughts and behaviors. However, there is limited evidence of successful interventions to support young people in the moment of their distress. Digital interventions are... Read More about Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies.

Identifying Digital Markers of ADHD in a Remote Monitoring Setting: Prospective Observational Study (2023)
Journal Article
Sankesara, H., Denyer, H., Sun, S., Deng, Q., Ranjan, Y., Conde, P., Rashid, Z., Asherson, P., Bilbow, A., Groom, M., Hollis, C., Dobson, R. J., Folarin, A., & Kuntsi, J. (2025). Identifying Digital Markers of ADHD in a Remote Monitoring Setting: Prospective Observational Study. JMIR Formative Research, 9, Article e54531. https://doi.org/10.2196/54531

Background:
The symptoms and associated characteristics of attention deficit hyperactivity disorder (ADHD) are typically assessed in person at a clinic or in a research lab. Mobile health offers a new approach to obtaining additional passively and c... Read More about Identifying Digital Markers of ADHD in a Remote Monitoring Setting: Prospective Observational Study.

Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data (2023)
Journal Article
Jack, R. H., Joseph, R. M., Hollis, C., Hippisley-Cox, J., Butler, D., Waldram, D., & Coupland, C. (2023). Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data. BMJ Mental Health, 26(1), Article e300855. https://doi.org/10.1136/bmjment-2023-300855

Background There is an increasing demand for mental health services for young people, which may vary across the year.

Objective To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in... Read More about Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.

Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation (2023)
Journal Article
Hollis, C., Hall, C. L., Khan, K., Le Novere, M., Marston, L., Jones, R., Hunter, R., Brown, B. J., Sanderson, C., Andrén, P., Bennett, S. D., Chamberlain, L. R., Bethan Davies, E., Evans, A., Kouzoupi, N., McKenzie, C., Heyman, I., Kilgariff, J., Glazebrook, C., Mataix-Cols, D., …Murphy, T. (2023). Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation. Health Technology Assessment, 27(18), 1-120. https://doi.org/10.3310/cpms3211

Background:

Behavioural therapy for tics is difficult to access, and little is known about its effectiveness when delivered online.

Objective:

To investigate the clinical and cost-effectiveness of an online-delivered, therapist and parent-... Read More about Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation.

Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of ADHD: a systematic review and meta-analysis (2023)
Journal Article
Bellato, A., Hall, C. L., Groom, M. J., Simonoff, E., Thapar, A., Hollis, C., & Cortese, S. (2024). Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of ADHD: a systematic review and meta-analysis. Journal of Child Psychology and Psychiatry, 65(6), 845-861. https://doi.org/10.1111/jcpp.13901

Background
Several computerised cognitive tests (e.g. continuous performance test) have been developed to support the clinical assessment of attention-deficit/hyperactivity disorder (ADHD). Here, we appraised the evidence-base underpinning the use o... Read More about Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of ADHD: a systematic review and meta-analysis.

Developing precision computerised cognitive behavioural therapy (cCBT) for adolescent depression: a pilot and feasibility protocol for the SPARX-UK trial (2023)
Preprint / Working Paper
Khan, K., Hall, C. L., Babbage, C., Dodzo, S., Greenhalgh, C., Lucassen, M., Merry, S., Sayal, K., Sprange, K., Stasiak, K., Tench, C. R., Townsend, E., Stallard, P., & Hollis, C. Developing precision computerised cognitive behavioural therapy (cCBT) for adolescent depression: a pilot and feasibility protocol for the SPARX-UK trial

Background:

A serious game (SPARX), developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depression and anxiety in adolescents with mild to moderate depression. Howev... Read More about Developing precision computerised cognitive behavioural therapy (cCBT) for adolescent depression: a pilot and feasibility protocol for the SPARX-UK trial.

The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know? (2023)
Journal Article
Hall, C. L., Bellato, A., Kirk, J. D., & Hollis, C. (2023). The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?. Paediatrics and Child Health, 33(9), 259-264. https://doi.org/10.1016/j.paed.2023.06.006

The assessment of Attention-Deficit/Hyperactivity Disorder (ADHD) typically relies on subjective observer reports from parents, teachers, or the young person, combined with clinical observation and history. Children and young people often experience... Read More about The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?.

Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism (2023)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Ropar, D., Hollis, C., & Groom, M. J. (2023). Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism. Cortex, 166, 306-321. https://doi.org/10.1016/j.cortex.2023.06.002

Introduction
Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) may be characterized by different profiles of visual attention orienting. However, there are also many inconsistent findings emerging from the literature... Read More about Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism.

Remote administration of ADHD-sensitive cognitive tasks: a pilot study (2023)
Journal Article
Sun, S., Denyer, H., Sankesara, H., Deng, Q., Ranjan, Y., Conde, P., Rashid, Z., Bendayan, R., Asherson, P., Bilbow, A., Groom, M., Hollis, C., Folarin, A. A., Dobson, R. J. B., & Kuntsi, J. (2023). Remote administration of ADHD-sensitive cognitive tasks: a pilot study. Journal of Attention Disorders, 27(9), 1040-1050. https://doi.org/10.1177/10870547231172

Objective:
We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous... Read More about Remote administration of ADHD-sensitive cognitive tasks: a pilot study.

We need timely access to mental health data: implications of the Goldacre review (2023)
Journal Article
Astle, D. E., Moore, A., Marryat, L., Viding, E., Mansfield, K. L., Fazel, M., Pierce, M., Abel, K. M., Green, J., Broome, M. R., John, A., Broome, M. R., Upthegrove, R., Bould, H., Minnis, H., Gajwani, R., Groom, M. J., Hollis, C., Liddle, E., Sayal, K., …Ford, T. J. (2023). We need timely access to mental health data: implications of the Goldacre review. Lancet Psychiatry, 10(4), 242-244. https://doi.org/10.1016/S2215-0366%2823%2900030-5

The Goldacre review, published in April, 2022, 1 is a landmark evaluation of the use, availability, and safety of National Health Service (NHS) data across all four nations of the UK. The review underscores the necessary role of data in driving healt... Read More about We need timely access to mental health data: implications of the Goldacre review.

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study (2023)
Journal Article
Andrews, J. A., Craven, M. P., Guo, B., Weyer, J., Lees, S., Zormpas, S. I., Thorpe, S. E., Devonshire, J., San Antonio-Arce, V., Whitehouse, W. P., Julie, J., Malins, S., Hammers, A., Reif, A., Ruhe, H. G., Durbano, F., Barlati, S., Sen, A., Frederiksen, J. L., Martinelli, A., …RADAR-CNS Consortium. (2023). Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study. JMIR Neurotechnology, 2, Article e41439. https://doi.org/10.2196/41439

Background: Multiple sclerosis (MS), epilepsy, and depression are chronic central nervous system conditions in which remote measurement technology (RMT) may offer benefits compared with usual assessment. We previously worked with clinicians, patients... Read More about Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study.