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Professor CAROL COUPLAND's Outputs (137)

Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study (2025)
Journal Article
Patone, M., Snelling, A. J., Tibble, H., Coupland, C., Sheikh, A., & Hippisley-Cox, J. (2025). Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study. Communications Medicine, 5(1), Article 20. https://doi.org/10.1038/s43856-024-00720-7

Background
Sotrovimab is a neutralising monoclonal antibody (nMAB) currently available to treat extremely clinically vulnerable COVID-19 patients in England. Trials have shown it to have mild to moderate side effects, however, evidence regarding its... Read More about Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study.

Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study (2024)
Journal Article
Iyen, B., Coupland, C., Bell, B., Orrell, M., Dening, T., & Avery, T. (2024). Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study. BMJ Medicine, 3(1), Article e000799. https://doi.org/10.1136/bmjmed-2023-000799

Objective To investigate whether different anticholinergic drug treatments for overactive bladder have differential risks for incident dementia, in a large representative population of older adults in England.

Design Nested case-control study.... Read More about Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.

Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England (2024)
Journal Article
Tzu-Hsuan Chen, D., Hirst, J., Coupland, C. A., Liao, W., Baldwin, D. R., & Hippisley-Cox, J. (2025). Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England. The Lancet Regional Health Europe, 48, Article 101124. https://doi.org/10.1016/j.lanepe.2024.101124

Background: Lung cancer is a leading cause of mortality, yet disparities in lung cancer across different sociodemographic groups in the UK remain unclear. This study investigates ethnicity and sociodemographic disparities and differences in lung canc... Read More about Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2025). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Cost-effectiveness of the ‘Stay One Step Ahead’ Home Safety programme for the prevention of injuries among children under 5 years (2024)
Journal Article
Jones, M., Orton, E., Taylor, M. J., Timblin, C., Clarke, R., Watson, M. C., Hayes, M., Patel, T., Coupland, C., & Kendrick, D. (2024). Cost-effectiveness of the ‘Stay One Step Ahead’ Home Safety programme for the prevention of injuries among children under 5 years. Injury Prevention, https://doi.org/10.1136/ip-2024-045236

Background Unintentional injuries are a common cause of morbidity and mortality in the under-5s, but undertaking home safety practices can reduce injury risk. Stay One Step Ahead (SOSA) is an evidence-based standardised home safety programme. This st... Read More about Cost-effectiveness of the ‘Stay One Step Ahead’ Home Safety programme for the prevention of injuries among children under 5 years.

Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records (2024)
Journal Article
Cardwell, C. R., Ranger, T. A., Labeit, A. M., Coupland, C. A. C., Hicks, B., Hughes, C., McMenamin, Ú., Mei, X. W., Murchie, P., & Hippisley-Cox, J. (in press). Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records. British Journal of Cancer, https://doi.org/10.1038/s41416-024-02767-8

Background: There is limited evidence on the safety of Hormone Replacement Therapy (HRT) in women with cancer. Therefore, we systematically examined HRT use and cancer-specific mortality in women with 17 site-specific cancers. Methods: Women newly di... Read More about Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records.

Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England (2024)
Journal Article
Chen, D. T.-H., Copland, E., Hirst, J. A., Mi, E., Dixon, S., Coupland, C., & Hippisley-Cox, J. (2024). Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England. BMC Medicine, 22(1), Article 237. https://doi.org/10.1186/s12916-024-03457-1

Background: Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real world data on vaccine uptake, effectiveness and safety... Read More about Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England.

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England (2024)
Journal Article
Copland, E., Patone, M., Saatci, D., Handunnetthi, L., Hirst, J., Hunt, D. P. J., Mills, N. L., Moss, P., Sheikh, A., Coupland, C. A., Harnden, A., Robertson, C., & Hippisley-Cox, J. (2024). Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England. Nature Communications, 15(1), Article 3822. https://doi.org/10.1038/s41467-024-47745-z

The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes af... Read More about Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England.

Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study (2024)
Journal Article
Kalfas, M., Ayling, K., Jia, R., Coupland, C., Vedhara, K., & Chalder, T. (2024). Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study. Stress, 27(1), Article 2352117. https://doi.org/10.1080/10253890.2024.2352117

The COVID-19 pandemic and consequent lockdowns had a substantial impact on mental health. Distress and fatigue are highly correlated. However, little is known about the determinants of fatigue in the general population during the pandemic. This study... Read More about Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study.

Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model (2024)
Journal Article
Clift, A. K., Tan, P. S., Patone, M., Liao, W., Coupland, C., Bashford-Rogers, R., Sivakumar, S., & Hippisley-Cox, J. (2024). Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model. British Journal of Cancer, 130, 1969-1978. https://doi.org/10.1038/s41416-024-02693-9

Background: The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More nuanced stratification could... Read More about Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model.

Development and validation of a new algorithm for improved cardiovascular risk prediction (2024)
Journal Article
Hippisley-Cox, J., Coupland, C. A. C., Bafadhel, M., Russell, R. E. K., Sheikh, A., Brindle, P., & Channon, K. M. (2024). Development and validation of a new algorithm for improved cardiovascular risk prediction. Nature Medicine, 30, 1440-1447. https://doi.org/10.1038/s41591-024-02905-y

QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which we have named QR4, that incorporates novel risk fac... Read More about Development and validation of a new algorithm for improved cardiovascular risk prediction.

Effectiveness and safety of COVID-19 vaccination in people with blood cancer (2024)
Journal Article
Copland, E., Hirst, J., Mi, E., Patone, M., Chen, D., Coupland, C., & Hippisley-Cox, J. (2024). Effectiveness and safety of COVID-19 vaccination in people with blood cancer. European Journal of Cancer, 201, Article 113603. https://doi.org/10.1016/j.ejca.2024.113603

Background
People with blood cancer have increased risk of severe COVID-19 outcomes and poor response to vaccination. We assessed the safety and effectiveness of COVID-19 vaccines in this vulnerable group compared to the general population.
Methods... Read More about Effectiveness and safety of COVID-19 vaccination in people with blood cancer.

Dynamic updating of clinical survival prediction models in a changing environment (2023)
Journal Article
Tanner, K. T., Keogh, R. H., Coupland, C. A. C., Hippisley-Cox, J., & Diaz-Ordaz, K. (2023). Dynamic updating of clinical survival prediction models in a changing environment. Diagnostic and Prognostic Research, 7, Article 24. https://doi.org/10.1186/s41512-023-00163-z

Background
Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. In this study... Read More about Dynamic updating of clinical survival prediction models in a changing environment.

Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data (2023)
Journal Article
Jack, R. H., Joseph, R. M., Hollis, C., Hippisley-Cox, J., Butler, D., Waldram, D., & Coupland, C. (2023). Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data. BMJ Mental Health, 26(1), Article e300855. https://doi.org/10.1136/bmjment-2023-300855

Background There is an increasing demand for mental health services for young people, which may vary across the year.

Objective To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in... Read More about Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.

Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study (2023)
Journal Article
Thompson, W., Swain, S., Zhao, S. S., Kamps, A., Coupland, C., Kuo, C., Bierma-Zeinstra, S., Runhaar, J., Doherty, M., & Zhang, W. (2023). Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study. Osteoarthritis and Cartilage Open, 5(4), Article 100414. https://doi.org/10.1016/j.ocarto.2023.100414

Objective To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout.... Read More about Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study.

Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models (2023)
Journal Article
Hippisley-Cox, J., Mei, W., Fitzgerald, R., & Coupland, C. (2023). Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models. The Lancet Regional Health Europe, 32, Article 100700. https://doi.org/10.1016/j.lanepe.2023.100700

Background: Methods to identify patients at increased risk of oesophageal cancer are needed to better identify those for targeted screening. We aimed to derive and validate novel risk prediction algorithms (CanPredict) to estimate the 10-year risk of... Read More about Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records (2023)
Journal Article
Joseph, R. M., Knaggs, R. D., Coupland, C. A., Taylor, A., Vinogradova, Y., Butler, D., Gerrard, L., Waldram, D., Iyen, B., Akyea, R. K., Ashcroft, D. M., Avery, A. J., & Jack, R. H. (2023). Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records. BMC Geriatrics, 23(1), Article 435. https://doi.org/10.1186/s12877-023-04143-2

Background Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of routine medication reviews for old... Read More about Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database. (2023)
Journal Article
Swain, S., Coupland, C., Sarmanova, A., Kuo, C. F., Mallen, C., Doherty, M., & Zhang, W. (2023). Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database. British Journal of General Practice, 73(733), e615-e622. https://doi.org/10.3399/BJGP.2022.0419

Background The burden of osteoarthritis (OA) in UK primary care has not been investigated thoroughly.

Aim To estimate healthcare use and mortality in people with OA (overall and joint specific).

Design and setting A matched cohort study of adul... Read More about Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database..