Professor Penny Gowland's Outputs (16)

Assessing Water Content of the Human Colonic Chyme Using the MRI Parameter T1: A Key Biomarker of Colonic Function (2025)
Journal Article
Dellschaft, N., Murray, K., Ren, Y., Marciani, L., Gowland, P., Spiller, R., & Hoad, C. (2025). Assessing Water Content of the Human Colonic Chyme Using the MRI Parameter T1: A Key Biomarker of Colonic Function. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14999

Background
The human colon receives 2 L of fluid daily. Small changes in the efficacy of absorption can lead to altered stool consistency with diarrhea or constipation. Drugs and formulations can also alter colonic water, which can be assessed using... Read More about Assessing Water Content of the Human Colonic Chyme Using the MRI Parameter T1: A Key Biomarker of Colonic Function.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Alexia, A., Lange, R., Bois de Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2024). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Aran, A., Lange, R., Bois De Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2024). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

One Year of Gluten Free Diet Impacts Gut Function and Microbiome in Celiac Disease (2024)
Journal Article
Costigan, C. M., Warren, F. J., Duncan, A. P., Hoad, C. L., Lewis, N., Hill, T., Crooks, C. J., Morgan, P. S., Ciacci, C., Iovino, P., Sanders, D. S., Hildebrand, F., Gowland, P. A., Spiller, R. C., & Marciani, L. (2024). One Year of Gluten Free Diet Impacts Gut Function and Microbiome in Celiac Disease. Clinical Gastroenterology and Hepatology, https://doi.org/10.1016/j.cgh.2024.11.006

BACKGROUND & AIMS: Currently, the main treatment for celiac disease (CD) is gluten free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome.

METHODS: 36 newly diagnosed pat... Read More about One Year of Gluten Free Diet Impacts Gut Function and Microbiome in Celiac Disease.

Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review (2024)
Journal Article
Subhani, M., Dhanda, A., King, J. A., Warren, F. C., Creanor, S., Davies, M. J., Eldeghaidy, S., Bawden, S., Gowland, P. A., Bataller, R., Greenwood, J., Kaar, S., Bhala, N., & Aithal, G. P. (2024). Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review. eClinicalMedicine, 78, Article 102920. https://doi.org/10.1016/j.eclinm.2024.102920

Background
Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like p... Read More about Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2025). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, Article 115090. https://doi.org/10.1016/j.foodres.2024.115090

White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.

Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training (2024)
Journal Article
Willis, S. A., Malaikah, S., Bawden, S. J., Sherry, A. P., Sargeant, J. A., Coull, N. A., Bradley, C. R., Rowlands, A., Naim, I., Ennequin, G., Yates, T., Waheed, G., Gowland, P., Stensel, D. J., Webb, D. R., Davies, M. J., Aithal, G. P., & King, J. A. (2024). Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training. Diabetes, Obesity and Metabolism, 26(9), 4030-4042. https://doi.org/10.1111/dom.15755

Aims: To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods: In Part A (cross‐sectional desi... Read More about Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training.

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study (2024)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., Hill, T., Menys, A., Mainz, J. G., Barr, H., Gowland, P. A., Major, G., & Smyth, A. R. (2024). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. NIHR Open Research, 3, Article 65. https://doi.org/10.3310/nihropenres.13510.2

Background
People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung funct... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.

Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review (2024)
Journal Article
Akbar, T., Gershkovich, P., Stamatopoulos, K., Gowland, P. A., Stolnik, S., Butler, J., & Marciani, L. (2024). Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review. Molecular Pharmaceutics, 21(4), 1553-1562. https://doi.org/10.1021/acs.molpharmaceut.3c01123

Oral dosage forms are the most widely and frequently used formulations to deliver active pharmaceutical ingredients (APIs), due to their ease of administration and noninvasiveness. Knowledge of intragastric release rates and gastric mixing is crucial... Read More about Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review.

Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization (2024)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., Loganathan, S., Papadopoulos, M., Benninga, M. A., Devadason, D., & Marciani, L. (2024). Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization. PLoS ONE, 19(1), Article e0296311. https://doi.org/10.1371/journal.pone.0296311

Recent magnetic resonance imaging (MRI) studies showed that colonic volumes in children are different between health and functional constipation. The length of the colon has however been rarely measured and principally using unphysiological colon pre... Read More about Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization.

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. (2023)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., Hill, T., Menys, A., Mainz, J. G., Barr, H., Gowland, P. A., Major, G., & Smyth, A. R. (2023). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. NIHR Open Research, 3(65), 1-16. https://doi.org/10.3310/nihropenres.13510.1

Background

People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung fun... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes..

In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans (2023)
Journal Article
Almutairi, F., Alyami, J., Pritchard, S., Alsharef, W., Spiller, R. C., Gowland, P. A., Taylor, M. A., Marciani, L., & Hoad, C. L. (2023). In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans. Clinical Nutrition Open Science, 51, 35-43. https://doi.org/10.1016/j.nutos.2023.08.002

The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used to gain novel insight... Read More about In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans.

MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time (2023)
Journal Article
Alshammari, M. T., Alyami, A. S., Wilkinson-Smith, V., Spiller, R. C., Gowland, P., Marciani, L., Moran, G. W., & Hoad, C. L. (2023). MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time. Neurogastroenterology and Motility, 35(8), Article e14610. https://doi.org/10.1111/nmo.14610

Background: Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for assessing chyme mixing) on inter-obse... Read More about MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time.

Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction (2022)
Journal Article
Bawden, S. J., Hoad, C., Kaye, P., Stephenson, M., Dolman, G., James, M. W., Wilkes, E., Austin, A., Guha, I. N., Francis, S., Gowland, P., & Aithal, G. P. (2023). Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction. Magnetic Resonance Materials in Physics, Biology and Medicine, 36(4), 553-563. https://doi.org/10.1007/s10334-022-01052-0

Objective: Magnetic resonance spectroscopy (MRS) provides a powerful method of measuring fat fraction. However, previous studies have shown that MRS results give lower values compared with visual estimates from biopsies in fibrotic livers. This study... Read More about Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction.