Dr PAUL BRILEY's Outputs (7)

Opportunities and challenges to delivering a trial for depressive symptoms in primary care during the COVID-19 pandemic: insights from the Alpha-Stim-D randomised controlled trial (2025)
Journal Article
Patel, S., Patel, P., Boutry, C., Guo, B., Butler, D., Higton, F., McNaughton, R., Briley, P. M., Griffiths, C., Nixon, N., Prasad, V., Sayal, K., Smart, D., Zafar, A., Kai, J., & Morriss, R. (2025). Opportunities and challenges to delivering a trial for depressive symptoms in primary care during the COVID-19 pandemic: insights from the Alpha-Stim-D randomised controlled trial. Trials, 26(1), Article 62. https://doi.org/10.1186/s13063-025-08772-3

Background
Randomised controlled trials (RCTs) are widely regarded as the most powerful research design for evidence-based practice. However, recruiting to RCTs can be challenging resulting in heightened costs and delays in research completion and i... Read More about Opportunities and challenges to delivering a trial for depressive symptoms in primary care during the COVID-19 pandemic: insights from the Alpha-Stim-D randomised controlled trial.

Experiences of clinicians working in the inpatient and community mental health care pathway for young people in the UK (2024)
Journal Article
Shah, A., Holland, J., Briley, P. M., & Majumder, P. (2024). Experiences of clinicians working in the inpatient and community mental health care pathway for young people in the UK. British Journal of Healthcare Management, 30(12), 1-13. https://doi.org/10.12968/bjhc.2024.0020

Background/Aims
Increases in the complexity, severity and risk level of patients referred to child and adolescent mental health services has put considerable pressure on bed availability in adolescent psychiatric hospitals, resulting in lengthy admi... Read More about Experiences of clinicians working in the inpatient and community mental health care pathway for young people in the UK.

Acceptability, tolerability and safety of the BRIGhTMIND trial: Connectivity-guided intermittent theta-burst stimulation versus F3- repetitive transcranial magnetic stimulation for treatment-resistant depression. (2024)
Journal Article
Webster, L., Boutry, C., Thomson, L., Abdelghani, M., Barber, S., Briley, P. M., Kurkar, M., Lankappa, S., McAllister-Williams, R. H., Suazo Di Paola, A., & Morriss, R. (2025). Acceptability, tolerability and safety of the BRIGhTMIND trial: Connectivity-guided intermittent theta-burst stimulation versus F3- repetitive transcranial magnetic stimulation for treatment-resistant depression. Comprehensive Psychiatry, 136, Article 152544. https://doi.org/10.1016/j.comppsych.2024.152544

Background

The BRIGhTMIND study was a double-blind RCT comparing repetitive transcranial magnetic stimulation at a standard simulation site (the “F3” location given by the International 10–20 system, F3-rTMS) versus connectivity-guided intermitten... Read More about Acceptability, tolerability and safety of the BRIGhTMIND trial: Connectivity-guided intermittent theta-burst stimulation versus F3- repetitive transcranial magnetic stimulation for treatment-resistant depression..

Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial (2024)
Journal Article
Morriss, R., Briley, P. M., Webster, L., Abdelghani, M., Barber, S., Bates, P., Brookes, C., Hall, B., Ingram, L., Kurkar, M., Lankappa, S., Liddle, P. F., McAllister-Williams, R. H., O’Neil-Kerr, A., Pszczolkowski, S., Suazo Di Paola, A., Walters, Y., & Auer, D. P. (2024). Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial. Nature Medicine, 30(2), 403–413. https://doi.org/10.1038/s41591-023-02764-z

Disruption in reciprocal connectivity between the right anterior insula and the left dorsolateral prefrontal cortex is associated with depression and may be a target for neuromodulation. In a five-center, parallel, double-blind, randomized controlled... Read More about Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial.

Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial (2023)
Journal Article
Morriss, R., Patel, S., Boutry, C., Patel, P., Guo, B., Briley, P. M., Butler, D., Craven, M., Duncan, A., Griffiths, C., Higton, F., McNaughton, R., Nixon, N., Prasad, V., Sayal, K., Smart, D., Zafar, A., & Kai, J. (2023). Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial. Lancet Psychiatry, 10(3), 172-183. https://doi.org/10.1016/S2215-0366%2823%2900007-X

Background: Randomised sham-controlled trials of cranial electrostimulation with the Alpha-Stim Anxiety Insomnia and Depression (AID) device have reported improved anxiety and depression symptoms; however, no adequately powered sham-controlled trials... Read More about Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial.

Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial (2022)
Journal Article
Pszczolkowski, S., Cottam, W. J., Briley, P. M., Iwabuchi, S. J., Kaylor-Hughes, C., Shalabi, A., Babourina-Brooks, B., Berrington, A., Barber, S., Paola, A. S. D., Blamire, A., McAllister-Williams, H., Parikh, J., Abdelghani, M., Matthäus, L., Hauffe, R., Liddle, P., Auer, D. P., & Morriss, R. (2022). Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial. JMIR Research Protocols, 11(1), Article e31925. https://doi.org/10.2196/31925

Background: Depression is a substantial health and economic burden. In approximately one-third of patients, depression is resistant to first-line treatment; therefore, it is essential to find alternative treatments. Transcranial magnetic stimulation... Read More about Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial.

Development of human electrophysiological brain networks (2018)
Journal Article
Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., Brookes, M. J., & Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. https://doi.org/10.1152/jn.00293.2018

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.