Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo
(2019)
Journal Article
Francini, N., Cochrane, D., Illingworth, S., Purdie, L., Mantovani, G., Fisher, K., Seymour, L. W., Spain, S. G., & Alexander, C. (2019). Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo. Bioconjugate Chemistry, 30(4), 1244-1257. https://doi.org/10.1021/acs.bioconjchem.9b00189
Oncolytic viruses offer many advantages for cancer therapy when administered directly to confined solid tumors. However, the systemic delivery of these viruses is problematic because of the host immune response, undesired interactions with blood comp... Read More about Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo.