Aptamer BT200 blocks interaction of K1405-1408 in the VWF-A1 domain with macrophage LRP1
(2024)
Journal Article
Chan Kwo Chion, A., Byrne, C., Atiq, F., Doherty, D., Aguila, S., Fazavana, J., Lopes, P., Karampini, E., Amin, A., Preston, R. J., Baker, R. I., McKinnon, T. A., Zhu, S., Gilbert, J. C., Emsley, J., Jilma, B., & O'Donnell, J. S. (2024). Aptamer BT200 blocks interaction of K1405-1408 in the VWF-A1 domain with macrophage LRP1. Blood, https://doi.org/10.1182/blood.2024024055
Rondaptivan pegol (previously BT200) is a PEGylated RNA aptamer that binds to the A1 domain of VWF. Recent clinical trials demonstrated that BT200 significantly increased plasma VWF-FVIII levels by attenuating VWF clearance. The biological mechanism(... Read More about Aptamer BT200 blocks interaction of K1405-1408 in the VWF-A1 domain with macrophage LRP1.