Skip to main content

Research Repository

Advanced Search

All Outputs (2570)

Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation (2024)
Journal Article
Carroll, C., Manaprasertsak, A., Boffelli Castro, A., van den Bos, H., Spierings, D. C., Wardenaar, R., …Hammarlund, E. U. (2024). Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation. Cancer Research Communications, 4(3), 691-705. https://doi.org/10.1158/2767-9764.crc-23-0396

Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells... Read More about Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation.

The significance of multipole interactions for the stability of regular structures composed from charged particles. (2024)
Journal Article
Lindgren, E. B., Avis, H., Miller, A., Stamm, B., Besley, E., & Stace, A. J. (2024). The significance of multipole interactions for the stability of regular structures composed from charged particles. Journal of Colloid and Interface Science, 663, Article 458-466. https://doi.org/10.1016/j.jcis.2024.02.146

Identifying the forces responsible for stabilising binary particle lattices is key to the controlled fabrication of many new materials. Experiments have shown that the presence of charge can be integral to the formation of ordered arrays; however, a... Read More about The significance of multipole interactions for the stability of regular structures composed from charged particles..

The clinical significance of hypoalbuminaemia (2024)
Journal Article
Allison, S. P., & Lobo, D. N. (2024). The clinical significance of hypoalbuminaemia. Clinical Nutrition, 43(4), 909-914. https://doi.org/10.1016/j.clnu.2024.02.018

Albumin is a relatively small molecule with a radius of 7.5 nm and a molecular weight of 65 kDa. It is the most abundant protein in plasma, accounting for 60–75% of its oncotic pressure. Its concentration in plasma is merely one static measurement re... Read More about The clinical significance of hypoalbuminaemia.

A data-driven approach for scour detection around monopile-supported offshore wind turbines using Naive Bayes classification (2024)
Journal Article
Jawalageri, S., Ghiasi, R., Jalilvand, S., Prendergast, L. J., & Malekjafarian, A. (2024). A data-driven approach for scour detection around monopile-supported offshore wind turbines using Naive Bayes classification. Marine Structures, 95, Article 103565. https://doi.org/10.1016/j.marstruc.2023.103565

This paper proposes a novel data-driven framework for scour detection around offshore wind turbines (OWTs), where damage features are derived from wind and wave-induced acceleration signals collected along the tower. A numerical mod... Read More about A data-driven approach for scour detection around monopile-supported offshore wind turbines using Naive Bayes classification.

Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India (2024)
Journal Article
Kartik, P., Liu, J.-F., Sudarsan, R. T., Srinivasan, A., Jayaraman, D., Sivaprakasam, P., …Dandapani, M. (2024). Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India. JCO Global Oncology, 10(10), Article e2300214. https://doi.org/10.1200/go.23.00214

Purpose
Delayed diagnosis and poor awareness are significant barriers to the early intervention of pediatric brain tumors. This multicenter observational study aimed to evaluate the baseline routes and time to diagnosis for pediatric brain tumors in... Read More about Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India.

Original plant diversity and ecosystems of a small, remote oceanic island (Corvo, Azores): Implications for biodiversity conservation (2024)
Journal Article
Connor, S. E., Lewis, T., van Leeuwen, J. F., (Pim) van der Knaap, W., Schaefer, H., Porch, N., …Elias, R. B. (2024). Original plant diversity and ecosystems of a small, remote oceanic island (Corvo, Azores): Implications for biodiversity conservation. Biological Conservation, 291, Article 110512. https://doi.org/10.1016/j.biocon.2024.110512

Remote islands harbour many endemic species and unique ecosystems. They are also some of the world's most human-impacted systems. It is essential to understand how island species and ecosystems behaved prior to major anthropogenic d... Read More about Original plant diversity and ecosystems of a small, remote oceanic island (Corvo, Azores): Implications for biodiversity conservation.

Biochar carbon markets: A mitigation deterrence threat (2024)
Journal Article
Price, C., Morris, J., & Morris, C. (2024). Biochar carbon markets: A mitigation deterrence threat. Environmental Science and Policy, 154, Article 103704. https://doi.org/10.1016/j.envsci.2024.103704

This article aims to add to the emerging empirical mitigation deterrence literature by drawing on ongoing research into a particular form of greenhouse gas removal technology – biochar – and associated biochar carbon markets. As such, the aim of this... Read More about Biochar carbon markets: A mitigation deterrence threat.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., …James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Oxygen-resistant [FeFe]hydrogenases: new biocatalysis tools for clean energy and cascade reactions (2024)
Journal Article
Valetti, F., Morra, S., Barbieri, L., Dezzani, S., Ratto, A., Catucci, G., …Gilardi, G. (2024). Oxygen-resistant [FeFe]hydrogenases: new biocatalysis tools for clean energy and cascade reactions. Faraday Discussions, https://doi.org/10.1039/d4fd00010b

The use of enzymes to generate hydrogen, instead of using rare metal catalysts, is an exciting area of study in modern biochemistry and biotechnology, as well as biocatalysis driven by sustainable hydrogen. Thus far, the oxygen sensitivity of the fas... Read More about Oxygen-resistant [FeFe]hydrogenases: new biocatalysis tools for clean energy and cascade reactions.

Household energy price resilience in the face of gas and electricity market crises (2024)
Journal Article
Burlinson, A., Davillas, A., Giulietti, M., & Price, C. W. (2024). Household energy price resilience in the face of gas and electricity market crises. Energy Economics, 132, Article 107414. https://doi.org/10.1016/j.eneco.2024.107414

Despite the provision of financial support by the Government in response to the recent energy crisis, the resilience of households to the ensuing high energy prices remains to be established. In this study we propose a new definition of resilience, s... Read More about Household energy price resilience in the face of gas and electricity market crises.

Muddy, muddled, or muffled? Understanding the perception of audio quality in music by hearing aid users (2024)
Journal Article
Bannister, S., Greasley, A. E., Cox, T. J., Akeroyd, M. A., Barker, J., Fazenda, B., …Whitmer, W. M. (2024). Muddy, muddled, or muffled? Understanding the perception of audio quality in music by hearing aid users. Frontiers in Psychology, 15, https://doi.org/10.3389/fpsyg.2024.1310176

Introduction: Previous work on audio quality evaluation has demonstrated a developing convergence of the key perceptual attributes underlying judgments of quality, such as timbral, spatial and technical attributes. However, across existing research t... Read More about Muddy, muddled, or muffled? Understanding the perception of audio quality in music by hearing aid users.

Introduction to the special issue on new approaches to figurative language research (2024)
Journal Article
Olkoniemi, H., & Filik, R. (2024). Introduction to the special issue on new approaches to figurative language research. Discourse Processes, 61(1-2), 1-5. https://doi.org/10.1080/0163853x.2024.2312049

The use and interpretation of figurative expressions (e.g., irony, idiom, and metaphor) is an integral part of everyday human communication. Thus, the ability to comprehend figurative language underpins successful communication and social functioning... Read More about Introduction to the special issue on new approaches to figurative language research.

Sensing the Spin State of Room-Temperature Switchable Cyanometallate Frameworks with Nitrogen-Vacancy Centers in Nanodiamonds (2024)
Journal Article
Flinn, B. T., Rance, G. A., Cull, W. J., Cardillo-Zallo, I., Pitcairn, J., Cliffe, M. J., Fay, M. W., Tyler, A. J., Weare, B. L., Stoppiello, C. T., Davies, E. S., Mather, M. L., & Khlobystov, A. N. (2024). Sensing the Spin State of Room-Temperature Switchable Cyanometallate Frameworks with Nitrogen-Vacancy Centers in Nanodiamonds. ACS Nano, 18(9), 7148–7160. https://doi.org/10.1021/acsnano.3c11820

Room-temperature magnetically switchable materials play a vital role in current and upcoming quantum technologies, such as spintronics, molecular switches, and data storage devices. The increasing miniaturization of device architectures produces a ne... Read More about Sensing the Spin State of Room-Temperature Switchable Cyanometallate Frameworks with Nitrogen-Vacancy Centers in Nanodiamonds.

INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis (2024)
Journal Article
Anand-Ivell, R., Coutinho, A. R., Dai, Y., England, G., Goericke-Pesch, S., & Ivell, R. (2024). INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis. Animals, 14(5), Article 675. https://doi.org/10.3390/ani14050675

Insulin-like peptide 3 (INSL3) is a constitutive product of mature, adult-type Leydig cells of the testes and consequently in most mammals is an ideal biomarker with which to monitor pubertal development. A new heterologous time-resolved fluorescence... Read More about INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis.

Alternate Water Electrolysis (2024)
Journal Article
Chen, Y., & Chen, G. Z. (2024). Alternate Water Electrolysis. Next Sustainability, 3, Article 100029

Hydrogen gas is a net zero carbon emission clean fuel with an unmatched high specific energy. Water electrolysis is an important alternative method to produce hydrogen to the traditional fossil hydrocarbon reforming in industry. The main challenges o... Read More about Alternate Water Electrolysis.

On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations (2024)
Journal Article
Helmer, M., Warrington, S., Mohammadi-Nejad, A., Ji, J. L., Howell, A., Rosand, B., …Murray, J. D. (2024). On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations. Communications Biology, 7(1), Article 217. https://doi.org/10.1038/s42003-024-05869-4

Associations between datasets can be discovered through multivariate methods like Canonical Correlation Analysis (CCA) or Partial Least Squares (PLS). A requisite property for interpretability and generalizability of CCA/PLS associations is stability... Read More about On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations.

Improvements in Between-Vendor MRI Harmonization of Renal T2 Mapping using Stimulated Echo Compensation (2024)
Journal Article
Li, H., Daniel, A. J., Buchanan, C. E., Nery, F., Morris, D. M., Li, S., Huang, Y., Sousa, J. A., Sourbron, S., Mendichovszky, I. A., Thomas, D. L., Priest, A. N., & Francis, S. T. (2024). Improvements in Between-Vendor MRI Harmonization of Renal T2 Mapping using Stimulated Echo Compensation. Journal of Magnetic Resonance Imaging, 60(5), 2144-2155. https://doi.org/10.1002/jmri.29282

Background: T2 mapping is valuable to evaluate pathophysiology in kidney disease. However, variations in T2 relaxation time measurements across MR scanners and vendors may occur requiring additional correction. Purpose: To harmonize renal T2 measurem... Read More about Improvements in Between-Vendor MRI Harmonization of Renal T2 Mapping using Stimulated Echo Compensation.

Being Open-Minded about Open-Mindedness (2024)
Journal Article
Khorasanee, K. (2024). Being Open-Minded about Open-Mindedness. Philosophy, 99(2), 191-221. https://doi.org/10.1017/s0031819123000396

Within the field of virtue and vice epistemology open-mindedness is usually considered an archetypal virtue. Nevertheless, there is ongoing disagreement over how exactly it should be defined. In this paper I propose a novel definition of open-mindedn... Read More about Being Open-Minded about Open-Mindedness.