All Outputs (2492)

Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial (2024)
Journal Article
McIlroy, G., Lax, S., Gaskell, C., Jackson, A., Rhodes, M., Seale, T., Fox, Hopkins, L., Okosun, J., Barrington, S. F., Ringshausen, I., Ramsay, A. G., Calaminici, Linton, K., & Bishton, M. (2024). Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial. BMC Cancer, 24, Article 370. https://doi.org/10.1186/s12885-024-12112-0

Background
Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few a... Read More about Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial.

The effects of extreme heat on human health in tropical Africa (2024)
Journal Article
Kunda, J. J., Gosling, S. N., & Foody, G. M. (2024). The effects of extreme heat on human health in tropical Africa. International Journal of Biometeorology, 68, 1015-1033. https://doi.org/10.1007/s00484-024-02650-4

This review examines high-quality research evidence that synthesises the effects of extreme heat on human health in tropical Africa. Web of Science (WoS) was used to identify research articles on the effects extreme heat, humidity, Wet-bulb Globe Tem... Read More about The effects of extreme heat on human health in tropical Africa.

Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community (2024)
Journal Article
Dalby, M. J., Pekovic‐Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty‐Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community. BioEssays, 46(5), Article 2300223. https://doi.org/10.1002/bies.202300223

Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and... Read More about Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.

SnoRNAs in cardiovascular development, function, and disease (2024)
Journal Article
Chabronova, A., Holmes, T. L., Hoang, D. M., Denning, C., James, V., Smith, J. G. W., & Peffers, M. J. (2024). SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine, 30(6), 562-578. https://doi.org/10.1016/j.molmed.2024.03.004

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hy... Read More about SnoRNAs in cardiovascular development, function, and disease.

Exploring Opportunities for Vehicle-to-Grid Implementation through Demonstration Projects (2024)
Journal Article
Waldron, J., Rodrigues, L., Deb, S., Gillott, M., Naylor, S., & Rimmer, C. (2024). Exploring Opportunities for Vehicle-to-Grid Implementation through Demonstration Projects. Energies, 17(7), Article 1549. https://doi.org/10.3390/en17071549

Global warming, pollution, and increasing energy demand have compelled electrification of the transport sector. Electric vehicles are not only an attractive and cleaner mode of transport, but they also possess the capacity to offer flexible storage a... Read More about Exploring Opportunities for Vehicle-to-Grid Implementation through Demonstration Projects.

Dicalcium ferrite: A chemical heat pump in integrated carbon capture and chemical looping combustion for the steel industry (2024)
Journal Article
Sukma, M. S., Zheng, Y., & Scott, S. A. (2024). Dicalcium ferrite: A chemical heat pump in integrated carbon capture and chemical looping combustion for the steel industry. Chemical Engineering Journal, 488, Article 150658. https://doi.org/10.1016/j.cej.2024.150658

An integrated calcium and chemical looping combustion using dicalcium ferrite (Ca2Fe2O5, C2F), a mixed phase from iron and calcium oxides, is proposed here to remove carbon (CO + CO2) contained in the blast furnace gas from the steel industry. C2F is... Read More about Dicalcium ferrite: A chemical heat pump in integrated carbon capture and chemical looping combustion for the steel industry.

Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma (2024)
Journal Article
Wongrakpanich, A., Bui Thi Thu, H., Sakchaisri, K., Taresco, V., Cuzzucoli Crucitti, V., Bunsupa, S., & Suksiriworapong, J. (2024). Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma. Journal of Drug Delivery Science and Technology, 95, Article 105610. https://doi.org/10.1016/j.jddst.2024.105610

This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on synergistic to... Read More about Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma.

Phylogenetic insights into the terrestrial snails Helicoidei (Gastropoda: Stylommatophora) with special emphasis on the Camaenidae (2024)
Journal Article
Zhang, G., Naggs, F., Andrus, P. S., & Wade, C. M. (2024). Phylogenetic insights into the terrestrial snails Helicoidei (Gastropoda: Stylommatophora) with special emphasis on the Camaenidae. Zoological Journal of the Linnean Society, Article zlae027. https://doi.org/10.1093/zoolinnean/zlae027

The superfamily Helicoidei are a widely distributed and diverse infraorder of land snails and slugs. Here, we constructed a phylogenetic tree based on sequences of the large subunit ribosomal RNA gene to investigate the relationships within the Helic... Read More about Phylogenetic insights into the terrestrial snails Helicoidei (Gastropoda: Stylommatophora) with special emphasis on the Camaenidae.

Behaviour support in dentistry: A Delphi study to agree terminology in behaviour management (2024)
Journal Article
Mac Giolla Phadraig, C., Healy, O., Fisal, A. A., Yarascavitch, C., van Harten, M., Nunn, J., Newton, T., Sturmey, P., Asimakopoulou, K., Daly, B., Hosey, M. T., Kammer, P. V., Dougall, A., Geddis‐Regan, A., Pradhan, A., Setiawan, A. S., Kerr, B., Friedman, C. S., Cornelius, B. W., Stirling, C., …Krämer, S. (2024). Behaviour support in dentistry: A Delphi study to agree terminology in behaviour management. Community Dentistry and Oral Epidemiology, 52(4), 550-571. https://doi.org/10.1111/cdoe.12953

Objectives: Dental behaviour support (DBS) describes all specific techniques practiced to support patients in their experience of professional oral healthcare. DBS is roughly synonymous with behaviour management, which is an outdated concept. There i... Read More about Behaviour support in dentistry: A Delphi study to agree terminology in behaviour management.

Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review (2024)
Journal Article
Papapetropoulos, A., Topouzis, S., Alexander, S. P. H., Cortese‐Krott, M., Kendall, D. A., Martemyanov, K. A., …Ferdinandy, P. (2024). Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review. British Journal of Pharmacology, 181(11), 1553-1575. https://doi.org/10.1111/bph.16337

In 2023, seventy novel drugs received market authorization for the first time in either Europe (by the EMA and the MHRA) or in the United States (by the FDA). Confirming a steady recent trend, more than half of these drugs target rare diseases or int... Read More about Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review.

Inter‐ and intraobserver agreement of antenatal cardiotocography assessments by maternity care professionals: A prospective study (2024)
Journal Article
Neppelenbroek, E. M., van der Heijden, O. W. H., de Vet, H. C. W., de Groot, A. J. J., Daemers, D. O. A., de Jonge, A., & Verhoeven, C. J. M. (2024). Inter‐ and intraobserver agreement of antenatal cardiotocography assessments by maternity care professionals: A prospective study. International Journal of Gynecology & Obstetrics, 166(3), 1114-1120. https://doi.org/10.1002/ijgo.15497

Objective: In the Netherlands, antenatal cardiotocography (aCTG) to assess fetal well‐being is performed in obstetrician‐led care. An innovative initiative was started to evaluate whether aCTG for specific indications—reduced fetal movements, externa... Read More about Inter‐ and intraobserver agreement of antenatal cardiotocography assessments by maternity care professionals: A prospective study.

Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data (2024)
Journal Article
Kolhe, N. V., Fluck, R. J., & Taal, M. W. (in press). Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data. BMC Infectious Diseases, 24(1), Article 346. https://doi.org/10.1186/s12879-024-09210-6

Background: This study explores regional variations in COVID-19 hospitalization rates, in-hospital mortality, and acute kidney injury (AKI) in England. We investigated the influence of population demographic characteristics, viral strain changes, and... Read More about Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data.

Tracking subjects' strategies in behavioural choice experiments at trial resolution. (2024)
Journal Article
Maggi, S., Hock, R. M., O'Neill, M., Buckley, M. J., Moran, P. M., Bast, T., …Humphries, M. D. (2024). Tracking subjects' strategies in behavioural choice experiments at trial resolution. eLife, 13, Article e86491. https://doi.org/10.7554/eLife.86491

Investigating how, when, and what subjects learn during decision-making tasks requires tracking their choice strategies on a trial-by-trial basis. Here we present a simple but effective probabilistic approach to tracking choice strategies at trial re... Read More about Tracking subjects' strategies in behavioural choice experiments at trial resolution..

Tinnitus in Children and Adolescents (2024)
Book Chapter
Nemholt, S. S., & Baguley, D. M. (2024). Tinnitus in Children and Adolescents. In W. Schlee, B. Langguth, D. De Ridder, S. Vanneste, T. Kleinjung, & A. R. Møller (Eds.), Textbook of Tinnitus ( 465-482). (Second Edition). Springer. https://doi.org/10.1007/978-3-031-35647-6_39

Childhood tinnitus remains an under-researched topic area, though clinical and research interest in increasing. The literature indicates that childhood experiences of tinnitus are broadly as common as they are in adults and that in some cases it can... Read More about Tinnitus in Children and Adolescents.

Mathematical models of coagulation—are we there yet? (2024)
Journal Article
Owen, M. J., Wright, J. R., Tuddenham, E. G., King, J. R., Goodall, A. H., & Dunster, J. L. (2024). Mathematical models of coagulation—are we there yet?. Journal of Thrombosis and Haemostasis, 22(6), 1689-1703. https://doi.org/10.1016/j.jtha.2024.03.009

Background
Mathematical models of coagulation have been developed to mirror thrombin generation in plasma, with the aim of investigating how variation in coagulation factor levels regulates hemostasis. However, current models vary in the reactions t... Read More about Mathematical models of coagulation—are we there yet?.

Broadening the Scope of Operations and Supply Chain Management Scholarship on Diversity, Equity, and Inclusion: Justice, Paradox, and Dialectical Lenses (2024)
Journal Article
Matthews, L., Gold, S., & Schleper, M. C. (2024). Broadening the Scope of Operations and Supply Chain Management Scholarship on Diversity, Equity, and Inclusion: Justice, Paradox, and Dialectical Lenses. Production and Operations Management, https://doi.org/10.1177/10591478241243384

Diversity, equity, and inclusion (DEI) has been gaining attention in operations and supply chain management (OSCM) research but is often narrowly framed and dominated by instrumental logic. We offer three lenses that potentially broaden the scope of... Read More about Broadening the Scope of Operations and Supply Chain Management Scholarship on Diversity, Equity, and Inclusion: Justice, Paradox, and Dialectical Lenses.

A core genome multi-locus sequence typing scheme for Streptococcus uberis: an evolution in typing a genetically diverse pathogen (2024)
Journal Article
Whiley, D., Jolley, K., Blanchard, A., Coffey, T., & Leigh, J. (2024). A core genome multi-locus sequence typing scheme for Streptococcus uberis: an evolution in typing a genetically diverse pathogen. Microbial Genomics, 10(3), https://doi.org/10.1099/mgen.0.001225

Streptococcus uberis is a globally endemic and poorly controlled cause of bovine mastitis impacting the sustainability of the modern dairy industry. A core genome was derived from 579 newly sequenced S. uberis isolates, along with 305 publicly availa... Read More about A core genome multi-locus sequence typing scheme for Streptococcus uberis: an evolution in typing a genetically diverse pathogen.

Evolution of Primary Research Studies in Digital Interventions for Mental Well-Being Promotion from 2004 to 2023: A Bibliometric Analysis of Studies on the Web of Science (2024)
Journal Article
Armaou, M., Pears, M., Konstantinidis, S. T., & Blake, H. (2024). Evolution of Primary Research Studies in Digital Interventions for Mental Well-Being Promotion from 2004 to 2023: A Bibliometric Analysis of Studies on the Web of Science. International Journal of Environmental Research and Public Health, 21(3), Article 375. https://doi.org/10.3390/ijerph21030375

Research into digital interventions for mental well-being promotion has grown in recent years, fuelled by the need to improve mental health prevention strategies and respond to challenges arising from the coronavirus (COVID-19) pandemic. This bibliom... Read More about Evolution of Primary Research Studies in Digital Interventions for Mental Well-Being Promotion from 2004 to 2023: A Bibliometric Analysis of Studies on the Web of Science.

Schemata of estrangement in Ursula K. Le Guin’s The Dispossessed (2024)
Journal Article
Whitt, R. J. (2024). Schemata of estrangement in Ursula K. Le Guin’s The Dispossessed. Language and Literature, 33(2), 111-129. https://doi.org/10.1177/09639470241240923

Ursula Le Guin’s novel The Dispossessed (1974) is the first literary treatment of anarchic utopianism, presenting the society on the moon Anarres as operating on social principles lacking any sort of State or governmental oversight (known in the nove... Read More about Schemata of estrangement in Ursula K. Le Guin’s The Dispossessed.

Effects of embedded walls on tunnelling-induced sandy ground displacements: a numerical investigation (2024)
Journal Article
Xu, J., Zheng, L., Song, G., Zhang, D., Sheil, B., & Marshall, A. M. (2024). Effects of embedded walls on tunnelling-induced sandy ground displacements: a numerical investigation. Géotechnique, https://doi.org/10.1680/jgeot.23.00307

Urban tunnelling projects pose significant risks to the integrity of nearby structures due to ground movements induced by the excavation process. Embedded walls are commonly employed as a protective measure to mitigate these adverse effects. This pap... Read More about Effects of embedded walls on tunnelling-induced sandy ground displacements: a numerical investigation.