All Outputs (3344)

Estimating the energy requirements for long term memory formation (2023)
Working Paper

Brains consume metabolic energy to process information, but also to store memories. The energy required for memory formation can be substantial, for instance in fruit flies memory formation leads to a shorter lifespan upon subsequent starvation (Mery... Read More about Estimating the energy requirements for long term memory formation.

Analysis of the response of a roadway bridge under extreme flooding-related events: Scour and debris-loading (2023)
Journal Article

Hydraulic actions on bridges are a leading cause of failure, especially due to the occurrence of scour erosion. Due to climate change, flooding and scour risks are exacerbating for bridges worldwide, leading to a significant stress burden on asset ma... Read More about Analysis of the response of a roadway bridge under extreme flooding-related events: Scour and debris-loading.

What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions (2023)
Journal Article

Aim Medicines non-adherence is associated with poorer outcomes and higher costs. COVID-19 affected access to healthcare, with increased reliance on remote methods, including medicines supply. This study aimed to identify what affected people’s adher... Read More about What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions.

"More Than a cliché": Experiencing Hybrid Gifting in the Wild (2023)
Journal Article

Gifting is socially and economically important. Studies of gifting physical objects have revealed motivations, values, and the tensions between them, while HCI research has revealed weaknesses of digital gifting and explored possibilities of hybrid g... Read More about "More Than a cliché": Experiencing Hybrid Gifting in the Wild.

The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor (2023)
Journal Article

Known off-target interactions frequently cause predictable drug side-effects (e.g., β1-antagonists used for heart disease, risk β2-mediated bronchospasm). Computer-aided drug design would improve if the structural basis of existing drug selectivity w... Read More about The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor.

Expression, assessment and significance of Ki67 expression in breast cancer: an update (2023)
Journal Article

Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation in breast cancer (BC). The Ki67 labelling index has prognostic and predictive value in patients with early-stage BC, particularl... Read More about Expression, assessment and significance of Ki67 expression in breast cancer: an update.

Stacking sequence optimisation of an aircraft wing skin (2023)
Journal Article

This paper demonstrates a stacking sequence optimisation process of a composite aircraft wing skin. A two-stage approach is employed to satisfy all sizing requirements of this industrial sized, medium altitude, long endurance drone. In the first stag... Read More about Stacking sequence optimisation of an aircraft wing skin.

Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny (2023)
Journal Article

There is conflicting evidence as to whether Porifera (sponges) or Ctenophora (comb jellies) comprise the root of the animal phylogeny. Support for either a Porifera-sister or Ctenophore-sister tree has been extensively examined in the context of mode... Read More about Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny.

The natural pattern of birth timing and gestational age in the U.S. compared to England, and the Netherlands (2023)
Journal Article

Objective To examine cross-national differences in gestational age over time in the U.S. and across three wealthy countries in 2020 as well as examine patterns of birth timing by hour of the day in home and spontaneous vaginal hospital births in the... Read More about The natural pattern of birth timing and gestational age in the U.S. compared to England, and the Netherlands.

The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up (2023)
Journal Article

Background: The routine assessment of progesterone receptor (PR) expression in breast cancer (BC) remains controversial. This study aimed to evaluate the role of PR expression in luminal BC, with emphasis on the definition of positivity and its progn... Read More about The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up.

Nonlinear dynamics of unstably stratified two-layer shear flow in a horizontal channel (2023)
Journal Article

The Rayleigh-Taylor instability at the interface of two sheared fluid layers in a horizontal channel is investigated in the absence of inertia. The dynamics of the flow is described by a nonlinear lubrication equation which is solved numerically for... Read More about Nonlinear dynamics of unstably stratified two-layer shear flow in a horizontal channel.

Solar Power for Resilient Health Systems in Nigeria: Regulatory, Financial and Organisational Options for Sustainable Business Models (2023)
Journal Article

Highlights • Solar power for healthcare in Nigeria needs external sources to cover OPEX costs. • Regulation must stimulate capital investment for efficient business models. • Bankable solar batteries imply cost allocations among public and private ac... Read More about Solar Power for Resilient Health Systems in Nigeria: Regulatory, Financial and Organisational Options for Sustainable Business Models.

An analysis of the positive effect of real earnings management on financial performance (2023)
Journal Article

Purpose REM models infer abnormal levels of cashflow from operations (AbCFO), selling, general and admin (AbSGA) and production expenses (AbProd) are opportunistic, based on the supposition that engaging in real activities to meet current earnings t... Read More about An analysis of the positive effect of real earnings management on financial performance.

Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and traumatic brain injury (2023)
Journal Article

Epigenetic processes have become increasingly relevant in understanding disease-modifying mechanisms. 5-Methylcytosine methylations of DNA (5mC) and RNA (m5C) have functional transcriptional and RNA translational consequences and are tightly regulate... Read More about Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and traumatic brain injury.

The Riemann problem for a generalized Burgers equation with spatially decaying sound speed. I Large‐time asymptotics (2023)
Journal Article

In this paper, we consider the classical Riemann problem for a generalized Burgers equation, u t + h α ( x ) u u x = u x x , $$\begin{equation*} u_t + h_{\alpha }(x) u u_x = u_{xx}, \end{equation*}$$ with a spatially dependent, nonlinear sound speed,... Read More about The Riemann problem for a generalized Burgers equation with spatially decaying sound speed. I Large‐time asymptotics.

Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice (2023)
Journal Article

There is growing evidence that poor paternal diet at the time of conception increase the risk of offspring developing a range of non-communicable metabolic diseases, such as obesity, diabetes and cardiovascular disease, in adulthood. We hypothesise t... Read More about Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice.

Use and uptake of technology by people with dementia and their supporters during the COVID-19 pandemic (2023)
Journal Article

Objective This rapid review aims to identify the types of technologies used by people with dementia and their supporters during the COVID-19 pandemic, and the issues which influenced technology adoption within their usual care routines. Methods... Read More about Use and uptake of technology by people with dementia and their supporters during the COVID-19 pandemic.

Patient and Public Involvement and Engagement for PhD Students (2023)
Working Paper

This paper aims to provide useful advice regarding the development of skills for patient and public involvement and engagement (PPIE) in research. The authors of this paper comprise experienced PhD supervisors and trainers, researchers leading PPIE a... Read More about Patient and Public Involvement and Engagement for PhD Students.

Shrinkage features, microstructure evolution and properties of Gd2O3-MgO optical composite ceramics with Zr as phase stabilizer (2023)
Journal Article

A novel composite ceramic, composed of equal-volumetric Zr-stabilized Gd2O3 and MgO phases, was prepared to be transparent in mid-wave infrared range. Zr stabilized Gd2O3 is proved to have a lower lattice parameter (10.7516Å) using XRD refinement. Pr... Read More about Shrinkage features, microstructure evolution and properties of Gd2O3-MgO optical composite ceramics with Zr as phase stabilizer.

Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial (2023)
Journal Article

Background: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 a... Read More about Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial.