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Update on state‐of‐the‐art for arterial spin labeling (ASL) human perfusion imaging outside of the brain

Taso, Manuel; Aramendía-Vidaurreta, Veronica; Englund, Erin K.; Francis, Susan; Franklin, Suzanne; Madhuranthakam, Ananth J.; Martirosian, Petros; Nayak, Krishna S.; Qin, Qin; Shao, Xingfeng; Thomas, David L.; Zun, Zungho; Fernández‐Seara, Maria A.; the ISMRM Perfusion Study Group


Manuel Taso

Veronica Aramendía-Vidaurreta

Erin K. Englund

Suzanne Franklin

Ananth J. Madhuranthakam

Petros Martirosian

Krishna S. Nayak

Qin Qin

Xingfeng Shao

David L. Thomas

Zungho Zun

Maria A. Fernández‐Seara

the ISMRM Perfusion Study Group


This review article provides an overview of developments for arterial spin labeling (ASL) perfusion imaging in the body (i.e., outside of the brain). It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group. In this review, we focus on specific challenges and developments tailored for ASL in a variety of body locations. After presenting common challenges, organ-specific reviews of challenges and developments are presented, including kidneys, lungs, heart (myocardium), placenta, eye (retina), liver, pancreas, and muscle, which are regions that have seen the most developments outside of the brain. Summaries and recommendations of acquisition parameters (when appropriate) are provided for each organ. We then explore the possibilities for wider adoption of body ASL based on large standardization efforts, as well as the potential opportunities based on recent advances in high/low-field systems and machine-learning. This review seeks to provide an overview of the current state-of-the-art of ASL for applications in the body, highlighting ongoing challenges and solutions that aim to enable more widespread use of the technique in clinical practice.


Taso, M., Aramendía-Vidaurreta, V., Englund, E. K., Francis, S., Franklin, S., Madhuranthakam, A. J., …the ISMRM Perfusion Study Group. (2023). Update on state‐of‐the‐art for arterial spin labeling (ASL) human perfusion imaging outside of the brain. Magnetic Resonance in Medicine, 89(5), 1754-1776.

Journal Article Type Review
Acceptance Date Feb 7, 2023
Online Publication Date Feb 6, 2023
Publication Date May 1, 2023
Deposit Date Jul 11, 2023
Journal Magnetic Resonance in Medicine
Print ISSN 0740-3194
Electronic ISSN 1522-2594
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 89
Issue 5
Pages 1754-1776
Keywords Radiology, Nuclear Medicine and imaging
Public URL
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