Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation

Crossland, Hannah; Pereira, Suzette L.; Smith, Kenneth; Phillips, Bethan E.; Atherton, Philip J.

doi:10.1016/j.jff.2019.03.022

All Outputs (3)

A statistical and biological response to an informatics appraisal of healthy aging gene signatures (2019)
Journal Article
Timmons, J. A., Gallagher, I. J., Sood, S., Phillips, B., Crossland, H., Howard, R., …Atherton, P. J. (2019). A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20(1), 1-4. https://doi.org/10.1186/s13059-019-1734-z

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. Read More about A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

Longevity‐related molecular pathways are subject to midlife “switch” in humans (2019)
Journal Article
Timmons, J. A., Volmar, C., Crossland, H., Phillips, B. E., Sood, S., Janczura, K. J., …Wahlestedt, C. (2019). Longevity‐related molecular pathways are subject to midlife “switch” in humans. Aging Cell, 18(4), Article e12970. https://doi.org/10.1111/acel.12970

Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation (2019)
Journal Article
Crossland, H., Pereira, S. L., Smith, K., Phillips, B. E., & Atherton, P. J. (2019). Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation. Journal of Functional Foods, 56, 216-223. https://doi.org/10.1016/j.jff.2019.03.022

Cocoa flavanols and fish oil omega-3 fatty acids are two bio-active nutrients that may improve muscle microvascular function, insulin sensitivity and mitochondrial function in older adults. We assessed changes in gene expression of these pathways in... Read More about Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation.