A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Timmons, James A.; Gallagher, Iain J.; Sood, Sanjana; Phillips, Bethan; Crossland, Hannah; Howard, Robert; Kraus, William E.; Atherton, Philip J.

Abstract

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.

Citation

Timmons, J. A., Gallagher, I. J., Sood, S., Phillips, B., Crossland, H., Howard, R., Kraus, W. E., & Atherton, P. J. (2019). A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20(1), 1-4. https://doi.org/10.1186/s13059-019-1734-z

• Journal Article Type: Article
• Acceptance Date: Jun 10, 2019
• Online Publication Date: Aug 2, 2019
• Publication Date: 2019-12
• Deposit Date: Aug 8, 2019
• Publicly Available Date: Aug 8, 2019
• Journal: Genome Biology
• Print ISSN: 1474-760X
• Electronic ISSN: 1465-6906
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 1
• Article Number: 152
• Pages: 1-4
• DOI: https://doi.org/10.1186/s13059-019-1734-z
• Public URL: https://nottingham-repository.worktribe.com/output/2407117
• Publisher URL: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1734-z
• Additional Information: The Research to this article has been published in Genome Biology 2015 16:185: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0750-x
• Contract Date: Aug 8, 2019